Results 71 to 80 of about 405 (144)

Restoring cefepime activity against multidrug-resistant KPC-producing Klebsiella pneumoniae by combination with boronic acid inhibitors, MB076 and S02030 [PDF]

: Foremost in the design of new β-lactamase inhibitors (BLIs) are the boronic acid transition state inhibitors (BATSIs). Two highly potent BATSIs being developed are S02030 and MB076 strategically designed to be active against cephalosporinases and ...
Bonomo R. A., Caselli E., Hujer A. M., Introvigne M. L., Mojica M. F., Nielsen T. B., Pantapalangkoor P., Papp-Wallace K. M., Prati F., Rao G. G., Rather P. N., Rojas L. J., Sharma R., Spellberg B., Taracila M. A., Yeshwante S.   +15 more
core   +1 more source

Biochemical and molecular characterization of GES and NDM engineered variants: interactions with β-lactams and inhibitors [PDF]

, 2019
Antibiotic resistance occurs when bacteria causing an infection survive after being exposed to a drug that, under normal conditions, would kill it or inhibit its growth.
PICCIRILLI, ALESSANDRA
core  

Gesetzliche Verpflichtungen des RKI und BfArM im Rahmen der Einstufung von Reserveantibiotika [PDF]

Antibiotikaresistenzen sind eine zunehmende Bedrohung und führen jährlich zu ca. 1,27 Millionen Todesfällen weltweit. Um dem zu begegnen, werden global und in Deutschland Konzepte entwickelt, die in der Regel auf multisektoralen Maßnahmen basieren ...
Abu Sin, Muna, Eckmanns, Tim, Gröschner, Karin, Hecht, Jane, Lilienthal, Nils, Pantke, Ellen, Stommel, Barbara   +6 more
core   +1 more source

Biofilm and wastewater dynamics in an activated-sludge process in the UK: insights into microbiome composition, metabolic activity, and antimicrobial resistance using 16S rRNA sequencing [PDF]

This study explores the bacterial microbiome contributing to the resistome in wastewater and biofilm communities within a wastewater treatment works in Scotland, UK.
Craft, John, Escudero, Ania, Hunter, Colin, Reid, Deborah, Spencer, Janice   +4 more
core   +1 more source

P24 In vitro activity of cefepime/enmetazobactam, and comparators, against OXA carbapenemase-positive Acinetobacter baumannii

JAC-Antimicrobial Resistance
Abstract Background Cefepime/enmetazobactam (FEP/META) is a new β-lactam/β-lactamase inhibitor combination with broad-spectrum activity against MDR Enterobacterales (including OXA-48-producing isolates) which has demonstrated superiority to piperacillin/tazobactam for the treatment of complicated ...
Ward, Jon, Dunkel, Nathalie, Quevedo, Juan, Morrisey, Ian, Santerre Henriksen, Anne   +4 more
openaire   +1 more source

P59 Focus on enmetazobactam chemical stability in association with cefepime for prolonged infusions, in syringe and elastomeric diffusers [PDF]

JAC Antimicrob Resist
Abstract Background Enmetazobactam, a N-methylated tazobactam derivative is a novel extended-spectrum β-lactamase inhibitor with a unique mechanism that overcomes tazobactam-resistant variants of class A β-lactamases, and is the first β-lactamase inhibitor approved in combination with cefepime in both
Ward, Jon, Akim, Chayem, Quevedo, Juan, Jemmely, Noëlle, D´Huart, Elise   +4 more
europepmc   +2 more sources

Estimating the Value of Aztreonam-Avibactam in Treating Metallo-beta-Lactamase-Producing Enterobacterales Infections in Spain Using the STEDI AMR Value Framework [PDF]

Antimicrobial resistance; Carbapenem-resistance; Cost effectivenessResistencia antimicrobiana; Resistencia a carbapenémicos; Coste-efectividadResistència antimicrobiana; Resistència a carbapenèmics; Cost-efectivitatIntroduction Treatments for serious ...
de Lossada, Alfonso, Ferrer, Ricard, LUQUE, SONIA, Maroto-Diaz, Marta, Martínez Martínez, Luis, Moya-Alarcón, Carlota, Moya-Alarcón, Carlota   +6 more
core   +1 more source

Resistance to oxyimino-cephalosporins conferred by an alternative mechanism of hydrolysis by the Acinetobacter-derived cephalosporinase-33 (ADC-33), a class C β-lactamase present in carbapenem-resistant Acinetobacter baumannii (CRAb) [PDF]

Antimicrobial resistance in Acinetobacter baumannii is partly mediated by chromosomal class C beta-lactamases, the Acinetobacter-derived cephalosporinases (ADCs).
Bethel, Christopher R., Bonomo, Robert A., Caselli, Emilia, Hujer, Andrea M., Hujer, Kristine M., Jarvis, Hannah R., June, Cynthia M., Powers, Rachel A., Prati, Fabio, Rudin, Susan D., Taracila, Magdalena A., Wallar, Bradley J., Ziegler, Zoe X.   +12 more
core   +1 more source

Infecção do trato urinário - uma revisão de literatura [PDF]

As infecções do trato urinário (ITU) são comuns e podem ser causadas por uma variedade de fatores. As causas principais incluem a introdução de bactérias na uretra, geralmente provenientes do intestino, que podem se multiplicar e causar infecção.
Felix, Isadora Pinheiro, Ferreira, Vitória Froes Miraglia Martins, Gonçalves, Victor Decat, Pongeluppi, Ana Clara Aguiar, Reggiani, Helena Campoli   +4 more
core   +1 more source

Real-World Evidence and Multidrug Resistant Infections: How Can We Leverage RWE to Improve Patient Outcome with the Novel Beta-Lactam and Beta-Lactam/Beta-Lactamase Inhibitor Combinations

Infection and Drug Resistance
Milo Gatti,1,2 Federico Pea1,2 1Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy; 2Clinical Pharmacology Unit, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, ItalyCorrespondence ...
Gatti M, Pea F
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