Results 101 to 110 of about 24,289 (229)

Bacterial Infections in End-Stage Liver Disease: Implications for Liver Transplantation

Transplantology
Bacterial infections are a common complication in patients with decompensated liver cirrhosis. The complex landscape of cirrhosis, characterized by immune paralysis and an exhausted response to exogenous triggers, explains the higher prevalence of such ...
Alberto Ferrarese, Marco Senzolo, Anna Maria Cattelan, Lolita Sasset, Sara Battistella, Alberto Zanetto, Giacomo Germani, Francesco Paolo Russo, Martina Gambato, Filippo Pelizzaro, Stefania Vio, Domenico Bassi, Umberto Cillo, Patrizia Burra   +13 more
doaj   +1 more source

Dose Selection for Ceftibuten Combined with Avibactam Tomilopil, a Potential Oral Alternative to Carbapenems for Patients with Complicated Urinary Tract Infections

The Journal of Clinical Pharmacology, Volume 66, Issue 9, September 2026.
Abstract There are currently no oral treatment options for infections caused by extended spectrum β‑lactamase‐producing Enterobacterales. Avibactam tomilopil, a novel oral prodrug of avibactam, is being developed in combination with the oral cephalosporin, ceftibuten, as a potential treatment for patients with complicated urinary tract infections ...
Siddhee A. Sahasrabudhe, Satoshi Shoji, Abhijeet S. Jakate, Bisrat K. Abraham, Sima S. Toussi, Benjamin J. Maligalig, Amanda S. Darekar, Sakambari Tripathy, Constantino Kantaridis, Josue K. Mfopou, Oxana Selivanova, Arthur Bergman, Negar Niki Alami, Ravi Shankar P. Singh   +13 more
wiley   +1 more source

Molecular epidemiology and the clinical impact of carbapenemase-producing Enterobacterales isolates among adult patients: aspects from a Romanian non-teaching hospital

Romanian Journal of Laboratory Medicine, 2020
Introduction: A dramatic increase of infections induced by carbapenemase-producing Enterobacterales (CPE) has been registered worldwide. The aim of this study was to evaluate the molecular epidemiology and the clinical impact of CPE strains isolated from
Főldes Annamária, Molnár Szabolcs, Bilca Doina-Veronica, Voidăzan Septimiu Toader, Székely Edit   +4 more
doaj   +1 more source

Microbial Signals in Cancer: Dissecting Host–Microbiota–Tumor Interactions and Potential Therapeutic Strategy

MedComm, Volume 7, Issue 9, September 2026.
Microbial signals from gut and tumor‐resident bacteria, fungi, viruses, and bacteriophages reshape immune and metabolic networks within the tumor microenvironment, thereby influencing cancer progression, treatment response. Therapeutic modulations, including dietary interventions, probiotics, antibiotics, fecal microbiota transplantation, engineered ...
Juan Lu, Mengjuan Xuan, Liang Yu, Zhongyang Xie, Qingfei Chu, Shihui Wei, Tuokai Wang, Chen Xue, Lanjuan Li   +8 more
wiley   +1 more source

Focused Update to International Consensus Recommendations for the Use of Prolonged‐Infusion Beta‐Lactam Antibiotics Among Severely Ill Adult Patients: Endorsed by the American College of Clinical Pharmacy, British Society for Antimicrobial Chemotherapy, Cystic Fibrosis Foundation, European Society of Clinical Microbiology and Infectious Diseases, Infectious Diseases Society of America, Society of Critical Care Medicine, and Society of Infectious Diseases Pharmacists

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 9, September 2026.
ABSTRACT In 2023, international consensus recommendations suggested the use of prolonged‐infusion beta‐lactam antibiotics over short‐infusion dosing in severely ill adult patients to improve mortality or clinical cure, although the certainty of evidence was very low. With the availability of several new randomized controlled trials (RCTs), this focused
Lisa T. Hong, Alireza FakhriRavari, Marta Ulldemolins, Jason A. Roberts, Robert A. Bonomo, Marc H. Scheetz, on behalf of the Prolonged‐Infusion Beta‐Lactam Consensus Panel, Jacinda C. Abdul‐Mutakabbir, Mohammad H. Alshaer, Matteo Bassetti, Robert A. Bonomo, Kevin J. Downes, Alireza FakhriRavari, Mark Gilchrist, Lisa T. Hong, Jason A. Roberts, Marc H. Scheetz, Thomas Tängdén, Marta Ulldemolins, David C. Young   +19 more
wiley   +1 more source

Gut Microbiome and Intestinal Colonization with Multidrug-Resistant Strains of Enterobacterales: An Interplay Between Microbial Communities

Background: The intestinal tract is a host to a high number of diverse bacteria, and the presence of multidrug-resistant (MDR) Enterobacterales strains acts as a reservoir and a source of infection.
László Sipos, Dóra Szabó, Béla Kocsis   +2 more
core   +1 more source

Enterobacterales Infection after Intestinal Dominance in Hospitalized Patients

, 2020
The Enterobacterales order of Gram-negative bacteria includes the common nosocomial pathogens Klebsiella pneumoniae, Escherichia coli, Serratia marcescens, and Enterobacter species.
Michael A. Bachman, Christine Bassis, Yuang Sun, Emily Mantlo, Krishna Rao, Anna Seekatz   +5 more
core   +1 more source

Real‐Life Study on Gilteritinib‐Related Infections (GilteRInf): An Italian SEIFEM Study

American Journal of Hematology, Volume 101, Issue 10, Page 2672-2676, October 2026.
Elisa Buzzatti, Irene Terrenato, Martina Tomassi, Federica Lessi, Sara Pezone, Cristina Papayannidis, Gianluca Martini, Fabio Forghieri, Luana Fianchi, Martina Quattrone, Nicola Fracchiolla, Claudio Fozza, Michela Abbenante, Anna Lina Piccioni, Davide Facchinelli, Claudia Maria Basilico, Caterina Buquicchio, Nicola Di Renzo, Monica Piedimonte, Maria Giovanna Cefalo, Daniele Armiento, Adriano Venditti, Alessandro Busca, Francesco Marchesi, Maria Ilaria Del Principe, Livio Pagano   +25 more
wiley   +1 more source

A Lytic Bacteriophage Cocktail Attenuates Carbapenem‐Resistant Klebsiella pneumoniae–Acinetobacter baumannii Mixed‐Species Biofilms and Reshapes Transcriptional Responses

Microbial Biotechnology, Volume 19, Issue 9, September 2026.
A lytic phage cocktail targeting CRKP–CRAB mixed biofilms was systematically evaluated through in vitro, device‐associated, and in vivo models. Integrated transcriptomic analysis revealed molecular responses underlying biofilm disruption, providing mechanistic insights and experimental evidence supporting phage cocktails as a promising strategy against
Xuefang Ren, Rui Zhu, Yijiang Yang, Xiaojuan You, Liuxiang Wang, Guangyu Fu, Yehuan Zheng, Chunxia Wang, Zhentao Wang, Yongwei Li   +9 more
wiley   +1 more source

Assessment of the efficacy of large volume delayed sampling primary culture and pathogen reduction in preventing septic reactions from platelet transfusions

Transfusion, Volume 66, Issue 9, Page 1846-1859, September 2026.
Abstract Background Many mitigation processes have been introduced to reduce septic transfusion reactions (STRs) caused by the transfusion of bacterially contaminated PLTs. Methods The efficacy of primary culture and pathogen reduction is assessed in this review using data from long‐term hemovigilance programs in the US, Canada, UK, France, Switzerland,
Michael R. Jacobs
wiley   +1 more source