ChemBioChem, Volume 27, Issue 8, April 2026.Vinylogous (vin) amino acids are rare and highly reactive building blocks of peptidic natural products. We report the heterologous production of the vin‐arginine harboring barnesin A, a potent cysteine protease inhibitor. Barnesin A biosynthesis is suggested to involve FabD from primary metabolism, and the corresponding NRPS–PKS megaenzyme shows strict
Sven Balluff +2 more
wiley +1 more source
, 2021 Abstract BackgroundDue to shrinking therapeutic options, infections due to Carbapenem-resistant Enterobacterales (CRE) are an urgent threat in healthcare systems. We compared the risk factors and outcomes of bacteremia secondary to CRE with bacteremia secondary to carbapenem susceptible Enterobacterales (CSE).MethodsWe conducted a retrospective
Fasih Ali Ahmed +8 more
openaire +1 more source
Increased resistance rates of extended-spectrum β-lactamase-producing Enterobacterales isolated from blood cultures in Brazil [PDF]
This study aimed to identify and evaluate the antimicrobial susceptibility profile of extended-spectrum β-lactamase (ESBL)-producing Enterobacterales isolated from blood cultures of patients with suspected sepsis.
Alves, Nathanael dos Santos +13 more
core +2 more sources
Food Science &Nutrition, Volume 14, Issue 4, April 2026.Crocin enhanced intestinal barrier integrity and alleviated colonic inflammation in DSS‐induced UC mice. Crocin promoted autophagy by targeting the AMPK/mTOR pathway. Crocin reshaped gut microbiota composition of UC mice. ABSTRACT Crocin has been widely recognized for its anti‐inflammatory and antioxidant properties.
Jiaoyang Xu +8 more
wiley +1 more source
Activity and resistance mechanisms of the third generation tetracyclines tigecycline, eravacycline and omadacycline against nationwide Spanish collections of carbapenemase-producing Enterobacterales and Acinetobacter baumannii [PDF]
Multicenter study[Abstract] Introduction: The rise in multidrug-resistant bacteria challenges clinical microbiology. Tigecycline, eravacycline, and omadacycline show promise against carbapenem-resistant Enterobacterales and Acinetobacter baumannii ...
Alonso-García, Isaac +15 more
core +1 more source
Health Science Reports, Volume 9, Issue 4, April 2026.ABSTRACT Background and Aims Pneumonia is an inflammatory condition of the lower respiratory tract, commonly caused by infection and associated with substantial morbidity and healthcare utilization. The burden of pneumonia on healthcare is exacerbated by limited data on pathogenic causes and associated antimicrobial resistance (AMR). Here, we conducted
Radmir Sarsenov +7 more
wiley +1 more source
Performance of two combination disk methods as confirmation for ESBL and AmpC presence in clinical Enterobacterales isolates [PDF]
Purpose: Guidelines recommend the use of a combination disk method (CDM) including cefepime and clavulanic acid as a confirmation method for ESBL detection.
Bode, L. G.M. +4 more
core +2 more sources
High prevalence and diversity of extended-spectrum β-lactamase and emergence of OXA-48 producing Enterobacterales in wildlife in Catalonia [PDF]
, 2019 The contract of LMG was supported by the Instituto Nacional de Investigaci?n y Tecnolog?a Agraria y Alimentaria (INIA) and the European Social Fund. AV was supported by a PIF grant from the Universitat Aut?noma de Barcelona.
Albamonte Rodríguez, Andreu +7 more
core +1 more source
Effects of Lactic Acid Bacteria on Fermentation Quality and Microbiome of Leymus chinensis Silage
MicrobiologyOpen, Volume 15, Issue 2, April 2026.Ensiled Leymus chinensis are an important feedstuff for ruminants in large parts of the world. These results suggested that the addition of Lactobacillus plantarum or Lactobacillus buchneri regulated the ensiling performance by shaping the microbial community and metabolic pathways.
Xiaowei Jiang +6 more
wiley +1 more source
Piperacillin-tazobactam vs. carbapenems for treating hospitalized patients with ESBL-producing Enterobacterales bloodstream infections: a systematic review and meta-analysis [PDF]
Objectives: To meta-analyze the clinical efficacy of piperacillin-tazobactam vs. carbapenems for treating hospitalized patients affected by extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales bloodstream infections (BSIs).
Cojutti, Pier Giorgio +2 more
core +1 more source