Results 121 to 130 of about 27,397 (239)

Inhibition of Targeted Bacterial Growth Using MazF‐Expressing Phagemids: A Novel Therapeutic Approach Based on Endoribonuclease Toxin Molecules

Microbiology and Immunology, Volume 70, Issue 4, Page 206-213, April 2026.
ABSTRACT The extensive and indiscriminate use of antibiotics, which are intended to halt bacterial growth or eliminate them, has unintentionally given rise to antimicrobial resistance (AMR), which is a critical threat to global health. In the pursuit of alternative solutions, researchers have focused on type II toxin–antitoxin systems prevalent within ...
Hana Hasegawa, Tatsuki Miyamoto, Rino Isshiki, Tomoyoshi Kaneko, Kenichi Takasugi, Naohiro Noda, Satoshi Tsuneda   +6 more
wiley   +1 more source

Emergence of Tigecycline‐Resistant Pseudomonas aeruginosa Harbouring tmexC6D6‐toprJ1b From Hospital Sewage in Japan

Environmental Microbiology Reports, Volume 18, Issue 2, April 2026.
This study isolated a Pseudomonas aeruginosa strain (KAM950) carrying the tmexCD‐toprJ gene cluster from hospital sewage in Japan. The strain exhibited reduced susceptibility to tigecycline and carbapenems, harboured chromosomal tmexC6D6‐toprJ1b and oprD disruption, and belonged to epidemic clone ST244, emphasising emerging multidrug resistance and the
Shotaro Maehana, Masato Suzuki, Naoko Ishimura, Hiroki Izawa, Ryotaro Eda, Masaki Nakamura, Mohan Amarasiri, Takashi Furukawa, Fumiaki Kojima, Kazunari Sei, Makoto Kubo   +10 more
wiley   +1 more source

A Cautionary Case for Host Assignment Based on Broad Environmental blaOXA Carriers

Environmental Microbiology Reports, Volume 18, Issue 2, April 2026.
Metagenomic reference‐based pipelines predominantly assigned antibiotic resistance genes to clinically associated taxa. However, cultivation‐based confirmation revealed diverse environmental hosts, demonstrating that database‐driven gene host predictions may overestimate pathogen involvement and require cautious interpretation in environmental ...
Hanseob Shin, Min Ki Jeon, Hor‐Gil Hur
wiley   +1 more source

Resistencia a colistina en enterobacterales

, 2022
RESUMEN La resistencia a los antimicrobianos representa en la actualidad uno de los principales problemas de salud pública a nivel mundial. En nuestro país, la mayoría de las infecciones nosocomiales son ocasionadas por gérmenes resistentes a múltiples antimicrobianos.
openaire   +1 more source

Mortality Risk Factors and Prognostic Analysis of Patients with Multi-Drug Resistant Enterobacterales Infection

Infection and Drug Resistance, 2022
Xinchun Wang,1,* Qi Li,2,* Jianbang Kang,1 Donghong Yin,1 Xiaoxia Li,1 Shuyun Wang,1 Qian Guo,1 Yan Song,1 Jing Wang,1 Jinju Duan1 1Department of Pharmacy, Second Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China ...
Wang X, Li Q, Kang J, Yin D, Li X, Wang S, Guo Q, Song Y, Wang J, Duan J   +9 more
doaj  

Enhancing diabetic foot osteomyelitis diagnosis with metagenomics next‐generation sequencing, proof of concept

Diabetic Medicine, Volume 43, Issue 4, April 2026.
The use of mNGS with the MinION tool clearly provides a significant advantage compared to routine culture by identifying a higher diversity of pathogens in diabetic foot osteomyelitis. It also highlights the value of this method in clinical decision making, despite the technical challenges inherent in metagenomic sequencing.
Madjid Morsli, Chloé Magnan, Florian Salipante, Adeline Dubois, Sophie Schuldiner, Nicolas Cellier, Albert Sotto, Jean‐Philippe Lavigne, Catherine Dunyach‐Remy   +8 more
wiley   +1 more source

Susceptibility of carbapenemase-producing Enterobacterales (CPE) to nitroxoline

Journal of Antimicrobial Chemotherapy, 2019
AbstractBackgroundInfections caused by carbapenemase-producing Enterobacterales (CPE) constitute a major global health concern and are associated with increased morbidity and mortality. Nitroxoline is an old antibiotic, which has recently been re-launched for the treatment of uncomplicated urinary tract infection.
Frieder Fuchs, Axel Hamprecht
openaire   +2 more sources

Establishing the reference broth microdilution MIC method for cefepime-taniborbactam

Journal of Clinical Microbiology
The investigational β-lactam/β-lactamase inhibitor combination cefepime-taniborbactam is intended as therapy for serious infections caused by Gram-negative pathogens resistant to third-generation cephalosporins and carbapenems.
Adam Belley, Susan M. Cusick, Dan C. Pevear, Laura Koeth, Jeanna DiFranco-Fisher, Nimmi Kothari, Stephen Hawser, Greg Moeck   +7 more
doaj   +1 more source

Statistical and machine learning methods to estimate the impact of antimicrobial resistance on patient outcomes [PDF]

Antimicrobial resistance (AMR) presents a complex, universal threat to healthcare whose estimated impact varies widely by population, microbiology, and analytical methodology.
Yoon, Chang Ho
core   +2 more sources

In vitro antibacterial activity of tigecycline against multidrug-resistant bacteria isolated at the Sourô Sanou University teaching hospital in Bobo-Dioulasso, Burkina Faso

African Journal of Laboratory Medicine
Background: Tigecycline, an antibiotic effective against multidrug-resistant bacteria (MDRB), remains inaccessible in Burkina Faso’s hospitals for urgent care. Given the resulting therapeutic challenges and mortality in emergency services, evidence-based
Odilon D. Kaboré, Mélissa J. Gonfouli, Merci Muhigwa, Abdourahmane Sow, Fernand Michodigni, André Nagalo, Jacques Zoungrana, Arsène Hema, Augustin Konkobo, Hervé Kafando, Adama Ouattara, Armel Poda, Sylvain Godreuil, Abdoul-Salam Ouedraogo   +13 more
doaj   +1 more source