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Characteristics of community-acquired carbapenem-resistant Enterobacterales
Journal of Antimicrobial Chemotherapy, 2022AbstractBackgroundCommunity-acquired carbapenem-resistant Enterobacterales (CA-CRE) are an important threat.MethodsIn CRACKLE-2, we defined patients with CA-CRE as admitted from home, without pre-existing conditions, and a positive culture within 48 h of admission.
Rima Shrestha +73 more
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Rapid detection of Enterobacterales that produce carbapenemases
Diagnostic Microbiology and Infectious Disease, 2020The rapid detection of carbapenemases among Enterobacterales in clinical laboratories is critical for management of patients, and infection prevention and control efforts.A study was designed to evaluate the performances of the RAPIDEC CARBA NP®, β-CARBA®, NG-Test CARBA 5®, modified carbapenem-inactivation method, and EDTA version (eCIM) assays against
Wilson W, Chan +3 more
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Polymyxin resistance in Enterobacterales: overview and epidemiology in the Americas
International Journal of Antimicrobial Agents, 2021The worldwide spread of carbapenem- and polymyxin-resistant Enterobacterales represents an urgent public-health threat. However, for most countries in the Americas, the available data are limited, although Latin America has been suggested as a silent spreading reservoir for isolates carrying plasmid-mediated polymyxin resistance mechanisms.
J. Rodríguez-Santiago +3 more
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Socioeconomic disparities in the prevalence of multidrug resistance in Enterobacterales
Infection Control & Hospital Epidemiology, 2023AbstractWe examined the association between multidrug resistance and socioeconomic status (SES), analyzing microbiological and ZIP-code–level socioeconomic data. Using generalized linear models, we determined that multidrug resistance is significantly and persistently more prevalent in samples taken from patients residing in low-income ZIP codes versus
Dylan R. Brown +4 more
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Defining Baseline Mechanisms of Cefiderocol Resistance in the Enterobacterales
Microbial Drug Resistance, 2022The objective of this study was to identify putative mechanisms contributing to baseline cefiderocol resistance among carbapenem-resistant Enterobacterales (CRE). We evaluated 56 clinical CRE isolates with no previous exposure to cefiderocol.
Patricia J. Simner +5 more
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Trends in Enterobacterales Bloodstream Infections in Children
PediatricsOBJECTIVES Enterobacterales bloodstream infections (E-BSI) cause a significant burden of disease in children and are associated with antimicrobial resistance. We assessed temporal changes in the population-based incidence of E-BSI in children in Queensland, Australia.
Gibbs, Anna A.M. +9 more
openaire +5 more sources
Journal of Clinical Microbiology, 2022
Ceftazidime-avibactam (CZA), a novel β-lactam/β-lactamase inhibitor combination, has good antibacterial activity against carbapenem-resistant Enterobacterales (CRE) producing class A and C and some class D carbapenemases, but in recent years, the emergence of CZA-resistant Enterobacterales ...
Luozhu Feng +9 more
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Ceftazidime-avibactam (CZA), a novel β-lactam/β-lactamase inhibitor combination, has good antibacterial activity against carbapenem-resistant Enterobacterales (CRE) producing class A and C and some class D carbapenemases, but in recent years, the emergence of CZA-resistant Enterobacterales ...
Luozhu Feng +9 more
openaire +2 more sources
Intestinal colonization with multidrug-resistant Enterobacterales (MDRE-IC) increases the risk of MDRE bloodstream infection (BSI). However, its impact on the overall risk of nosocomial Enterobacterales bloodstream infections (nE-BSIs) remains unclear. This study aimed to determine this risk and identify associated factors in hospitalized patients.This
Bruandet Amélie +2 more
exaly +4 more sources

