Results 91 to 100 of about 603,469 (215)

ДИСЛИПИДЕМИЯ И АССОЦИИРОВАНЫЕ МЕТАБОЛИЧЕСКИЕ ЗАБОЛЕВАНИЯ

Архивъ внутренней медицины, 2011
This article presents the pathogenesis of dyslipidemia and associated metabolic disorders with the position of lipid metabolism. The role of natural mechanism of cholesterol homeostasis changing was showed, functional disorders of the enterohepatic ...
О. Ш. Ойноткинова, Е. И. Дедов   +1 more
doaj   +1 more source

Organ‐Specific Human Microbiomes and Dysbiosis: Mechanistic Links to Disease and Emerging Therapeutic Strategies

Journal of Clinical Laboratory Analysis, Volume 40, Issue 18, September 2026.
Schematic overview of the human microbiome and major microbiota‐derived metabolites across body sites, highlighting the gut–brain, gut–heart, and gut–kidney axes in host physiology and disease. ABSTRACT Background The human microbiome is a dynamic and diverse community of microorganisms that affects susceptibility to illness and promotes wellness ...
Awadh Alanazi
wiley   +1 more source

Altered Bile Acid Transport in Liver Disease

Biomedicines
Background/Objectives: Bile acids, synthesized from cholesterol in the liver, are amphipathic molecules that play an integral role in lipid digestion and absorption, while also serving as systemic endocrine hormones.
Sarah Cayton, Lindsay C. Czuba
doaj   +1 more source

Lysosomal Dysfunction Is Associated With Intervertebral Disc Degeneration: Multiomics and Machine Learning Identify Molecular Subtypes and Hub Genes

The Journal of Gene Medicine, Volume 28, Issue 9, September 2026.
Intervertebral disc degeneration (IVDD) is linked to lysosomal dysfunction, impaired autophagic degradation, and cellular senescence. Integrating bulk and single‐cell transcriptomics with machine learning, this study identified two lysosome‐related molecular subtypes and four hub genes: HYAL1, MMD, PLD3, and ANK3.
Yang Yang, Hong Li, Yixuan Ou, Yaping Yu, Kaiqiang Sun, Shixing Chen, Chenglong Ji   +6 more
wiley   +1 more source

Bacterial deconjugation and enterohepatic circulation of norursocholic acid conjugates in rats

, 1991
Experiments were performed to define the metabolism of norusocholic acid (nUC) conjugates and to quantify to what extent the bile acid pool can be enriched in these bile acids.
B. Borgstrom, J. Lillienau
core   +1 more source

Effects of amoxicillin/clavulanic acid on the pharmacokinetics of valproic acid

Drug Design, Development and Therapy, 2015
Soo-Yun Lee,1 Wooseong Huh,2 Jin Ah Jung,3 Hye Min Yoo,2 Jae-Wook Ko,1,2 Jung-Ryul Kim2,4 1Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, 2Department of Clinical Pharmacology and Therapeutics, Samsung Medical Center, 
Lee SY, Huh W, Jung JA, Yoo HM, Ko JW, Kim JR   +5 more
doaj  

Baat‐Deficient Mice Recapitulate Elevated 7α‐Hydroxy‐3‐Oxo‐4‐Cholestenoic Acid Observed in a Japanese Patient With BAAT Deficiency

Journal of Inherited Metabolic Disease, Volume 49, Issue 5, September 2026.
ABSTRACTBile acid Coenzyme A: amino acid N‐acyltransferase (BAAT) catalyzes the conjugation of bile acids with taurine or glycine, a process essential for bile acid solubility and intestinal lipid absorption. Mutations in BAAT cause an inborn error of bile acid metabolism, typically characterized by reduced conjugated bile acids and fat‐soluble vitamin
Soma Koga, Hajime Takei, Ryutaro Tamura, Yugo Takaki, Hiroyuki Kusuhara, Hiroshi Nittono, Hisamitsu Hayashi   +6 more
wiley   +1 more source

Dynamics of Earth's Hadley Circulation [PDF]

, 2013
This thesis advances our understanding of the mechanisms controlling the Hadley circulation, and its interaction with eddies on planetary scales in particular. On Earth, and more generally in a rapidly rotating and differentially heated planet, planetary
Levine, Xavier Josselin
core   +1 more source

Quantifying Forms and Functions of Enterohepatic Bile Acid Pools in MiceSummary

Cellular and Molecular Gastroenterology and Hepatology
Backgrounds & Aims: Bile acids (BAs) are core gastrointestinal metabolites with dual functions in lipid absorption and cell signaling. BAs circulate between the liver and distal small intestine (i.e., ileum), yet the dynamics through which complex BA
Koichi Sudo, Amber Delmas-Eliason, Shannon Soucy, Kaitlyn E. Barrack, Jiabao Liu, Akshaya Balasubramanian, Chengyi Jenny Shu, Michael J. James, Courtney L. Hegner, Henry D. Dionne, Alex Rodriguez-Palacios, Henry M. Krause, George A. O’Toole, Saul J. Karpen, Paul A. Dawson, Daniel Schultz, Mark S. Sundrud   +16 more
doaj   +1 more source

Bile acid transporters

Journal of Lipid Research, 2009
In liver and intestine, transporters play a critical role in maintaining the enterohepatic circulation and bile acid homeostasis. Over the past two decades, there has been significant progress toward identifying the individual membrane transporters and ...
Paul A. Dawson, Tian Lan, Anuradha Rao
doaj   +1 more source