Results 81 to 90 of about 603,469 (215)

Microbiota Modification with Probiotics Induces Hepatic Bile Acid Synthesis via Downregulation of the Fxr-Fgf15 Axis in Mice

Cell Reports, 2014
Gut microbiota influences host health status by providing trophic, protective, and metabolic functions, including bile acid (BA) biotransformation.
Chiara Degirolamo, Stefania Rainaldi, Fabiola Bovenga, Stefania Murzilli, Antonio Moschetta   +4 more
doaj   +1 more source

Upcoming therapies for steatotic liver disease: Translating breakthroughs into clinical practice

Journal of Internal Medicine, Volume 300, Issue 4, Page 440-460, October 2026.
Abstract Metabolic dysfunction‐associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide and a leading cause of cirrhosis, hepatocellular carcinoma, and cardiometabolic morbidity. Often clinically silent until advanced fibrosis develops, management has largely relied on lifestyle interventions, with limited ...
Philip N. Newsome, Saima Ajaz
wiley   +1 more source

Codeine toxicity via breast Milk: Can this occur and implications for opiate therapy in children

British Journal of Clinical Pharmacology, Volume 92, Issue 9, Page 3012-3016, September 2026.
Codeine is commonly used in combination analgesic products. The use of codeine during breastfeeding can rarely be associated with serious adverse effects related to genetic polymorphisms affecting codeine's metabolism and disposition. Clinicians treating infants of breastfeeding mothers should be aware of this rare but potentially serious complication.
Michael Rieder
wiley   +1 more source

Management of Acute Colchicine Poisoning With Multiple Organ Dysfunction Syndrome: A Case Report

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Colchicine is a microtubule‐disrupting alkaloid used in the treatment of gout and familial Mediterranean fever. It has a narrow therapeutic window, and overdose is associated with a high risk of fatal toxicity. Colchicine poisoning may initially present with gastrointestinal symptoms resembling acute gastroenteritis, which can make early ...
Jintao Luo, Suying Ding, Lei Xu, Sheng Pu, Youxue Bao, Conglin Qin, Fenshuang Zheng   +6 more
wiley   +1 more source

Quantitative analysis of unconjugated and conjugated bile acids in duodenal fluid by densitometry after paper electrophoresis

Journal of Lipid Research, 1973
A new paper electrophoretic method for the separation of bile acids into five groups, (1) unconjugated, (2) glycine conjugates and (3) taurine conjugates, and (4) and (5) the respective monosulfates, is described.
Neil Kaplowitz, Norman B. Javitt
doaj   +1 more source

Plant Flavonoid—Enriched Functional Foods for Polycystic Ovary Syndrome: Dietary Sources, Bioavailability Enhancement, and Personalized Intervention Strategies

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
Plant flavonoids from fruits, vegetables, tea, and soybeans require food processing technologies (microencapsulation, nano‐encapsulation, lipid carriers, fermentation, food collaboration) to enhance bioavailability, enabling the development of functional foods for precision dietary intervention in PCOS.
Jianding Wang, Hejian Zhu, Qing Shen, Yinghua Zhong, Yunli Du, Wenxi Yu, Fang Mao, Zhitao Yao, Weiwei Zhu, Lirong Sun, Qiu Lin, Xiaomin Xu, Jiong Zhu   +12 more
wiley   +1 more source

Analysis of gut microecological characteristics and differences between children with biliary atresia and non-biliary atresia in infantile cholestasis

Frontiers in Cellular and Infection Microbiology
IntroductionIn infants with cholestasis, variations in the enterohepatic circulation of bile acids and the gut microbiota (GM) characteristics differ between those with biliary atresia (BA) and non-BA, prompting a differential analysis of their ...
Yajun Liu, Yuan Zhang, Cheng Guo, Muxia Li, Ye Wang, Lin Zhang   +5 more
doaj   +1 more source

7α-Hydroxylation of cholestanol by rat liver microsomes

Journal of Lipid Research, 1968
In a study of the mechanism whereby 5α-bile acids are formed from cholestanol, the 7α-hydroxylation of cholestanol was investigated in rat liver preparations in vitro.
Sarah Shefer, Susan Hauser, Erwin H. Mosbach   +2 more
doaj   +1 more source

Bile acid metabolism and signaling in human and animal health: A One Health perspective

iMetaOmics, Volume 3, Issue 3, September 2026.
Bile acids maintain host homeostasis through enterohepatic circulation, microbial transformation, and bile acid receptor signaling, thereby regulating glucose and lipid metabolism, intestinal barrier integrity, and immunity. These effects support human disease intervention and health‐oriented animal production, reducing drug dependence and residue ...
Lei Li, Shuai Liu, Zhijun Cao, Yangchun Cao, Shengru Wu, Lu Deng, Junhu Yao, Jun Zhang   +7 more
wiley   +1 more source

Nonabsorbable dietary fat enhances disposal of 2,2 ',4,4 '-tetrabromodiphenyl ether in rats through interruption of enterohepatic circulation

, 2006
Polybrominated diphenyl ethers are lipophilic persistent organic pollutants (POPs), which accumulate in the environment, leading to human exposure. The compounds exert a negative impact on human health.
Havinga, Rick, Hafkamp, Anja M., Bergman, Ake, Meijer, Lisethe, Sauer, Pieter J. J., Bosman, Wouter E., Verkade, Henkjan J., Verkade, Henkjan J.; id_orcid   +7 more
core   +1 more source