Results 71 to 80 of about 603,469 (215)

Evolution of substrate specificity for the bile salt transporter ASBT (SLC10A2)[S]

Journal of Lipid Research, 2012
The apical Na+-dependent bile salt transporter (ASBT/SLC10A2) is essential for maintaining the enterohepatic circulation of bile salts. It is not known when Slc10a2 evolved as a bile salt transporter or how it adapted to substantial changes in bile salt ...
Daniël A. Lionarons, James L. Boyer, Shi-Ying Cai   +2 more
doaj   +1 more source

Of mice and men—The emerging oral–gut–brain axis of health and disease

Periodontology 2000, EarlyView.
Abstract Objectives Oral health's inextricable links to systemic health are highlighted by the emerging oral–gut–brain axis and other well‐known axes. There is growing evidence of a complex oral–gut–brain axis linking mouth and gut microbiomes with the central nervous system.
Yvonne L. Hernandez‐Kapila, Daniel J. Weisenberger   +1 more
wiley   +1 more source

Hepatic overexpression of Abcb11 in mice promotes the conservation of bile acids within the enterohepatic circulation

, 2013
Henkel AS, Gooijert KE, Havinga R, Boverhof R, Green RM, Verkade HJ. Hepatic overexpression of Abcb11 in mice promotes the conservation of bile acids within the enterohepatic circulation.
Havinga, Rick, Boverhof, Renze, Gooijert, Karin E. R., Verkade, Henkjan J., Henkel, Anne S., Verkade, Henkjan J.; id_orcid, Green, Richard M.   +6 more
core   +1 more source

Integrated multi-omics implicates the gut microbiota and bilirubin in abdominal fat deposition in Huainan yellow chickens

Poultry Science
The Huainan yellow chicken is prized for its meat quality, but excessive abdominal fat deposition hampers its production efficiency. To investigate the underlying mechanisms, we compared high-fat deposition (HFD) and low-fat deposition (LFD) chickens ...
Yaxin Li, Zichun Dai, Jie Liu, Rong Chen, Huanxi Zhu, Mingming Lei   +5 more
doaj   +1 more source

Translating gut microbiome research into therapies for type 1 diabetes

Experimental Physiology, EarlyView.
Abstract Type 1 diabetes (T1D) is characterised by the loss of functional pancreatic β‐cells, for which lifelong insulin therapy remains the standard of care. Given that the gut microbiome can influence host health and that shifts in gut microbial profiles have been observed in T1D, growing interest has emerged in the role of the gut microbiome in T1D,
Shanti P. Kok, Max Nieuwdorp, Elena Rampanelli   +2 more
wiley   +1 more source

Fecal Microbiota Transplantation and Microbiota‐Based Therapeutics in Allogeneic Hematopoietic Stem Cell Transplantation: Current Evidence and Future Directions

Clinical Pharmacology &Therapeutics, Volume 120, Issue 4, Page 871-889, October 2026.
The intestinal microbiome is a key regulator of immune homeostasis, metabolism, and epithelial barrier integrity. In patients with malignant hematological diseases, particularly those undergoing hematopoietic stem cell transplantation, microbiome perturbations by reduced diversity, pathobiont expansion, and loss of beneficial metabolites are common as ...
Bálint Gergely Szabó, Dorina Korózs, Michal Bator, Krisztina Jeszenszky, Viktor Lakatos, László Gopcsa, Péter Reményi, János Sinkó   +7 more
wiley   +1 more source

The Pharmacokinetics Of Enterohepatic Circulation

, 2015
University of Minnesota Ph.D. dissertation. December 2015. Major: Experimental & Clinical Pharmacology. Advisor: Richard Brundage. 1 computer file (PDF); xi, 332 pages.The EnteroHepatic Circulation (EHC) is defined as a process that is composed of a ...
Okour, Malek
core  

EffectQ1: Please confirm the edits made to the article title are correct. of Enterohepatic Circulation on the Accumulation of Per- and Polyfluoroalkyl Substances: Evidence from Experimental and Computational Studies

, 2022
The pharmacokinetic characteristics of per- and polyfluoroalkyl substances (PFAS) affect their distribution and bioaccumulation in biological systems. The enterohepatic circulation leads to reabsorption of certain chemicals from bile back into blood and ...
Yawei Wang, Ling Wang, Guangliang Liu, Zhen Zhou (184390), Jie Zhang (64655), Cuiyun Wei, Zhe Hu, Jie Zhang, Jie Li, Ling Wang (56577), Yawei Wang (1445449), Huiming Cao (602566), Huiming Cao, Thanh Wang (1592713), Thanh Wang, Zhen Zhou, Zhe Hu (787283), Jie Li (15030), Cuiyun Wei (12065654), Guangliang Liu (1319427), Yong Liang (131898), Yong Liang   +21 more
core   +1 more source

Gallstone formation and hepatobiliary tumour risk: Clinical implications of the bile acid–gut microbiota axis

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
1. Irregular dietary patterns (e.g., late breakfast, reduced meal frequency) upregulate the bai gene cluster by disrupting cholecystokinin (CCK) release rhythms and gut microbiota circadian rhythms, leading to increased production of secondary bile acids, particularly DCA. High‐carbohydrate dietary patterns increase gallstone risk (OR = 1.329).
Rui Li, Yong Zhang, Kaishuang Cai, Shaojun Deng, Chaofeng Tan, Yunjie Li, Wenjin Liang   +6 more
wiley   +1 more source

Aging of Skeletal Muscle: From Molecular Mechanisms to Therapeutic Interventions

MedComm, Volume 7, Issue 10, October 2026.
Skeletal muscle aging is driven by coordinated local breakdown across myofibers, stem and stromal cells, immune and vascular compartments, and neuromuscular control. These mechanisms promote mitochondrial dysfunction, inflammation, senescence, impaired regeneration, fibrosis, myosteatosis, denervation, and functional decline.
Ting Liu, Yaomin Hu
wiley   +1 more source