Results 51 to 60 of about 13,632 (184)

Liver-targeted delivery of insulin-loaded nanoparticles via enterohepatic circulation of bile acids

, 2018
Liver is the primary acting site of insulin. In this study, we developed innovative nanoparticles for oral and liver-targeted delivery of insulin by using enterohepatic circulation of bile acids.
Guangrui Xu (168774), Ping Yao (290266), Zhe Zhang (81603), Hongxiang Li (1713490)   +3 more
core   +1 more source

PHYSIOLOGY OF CHOLESTEROL METABOLISM (THE REVIEW)

Acta Biomedica Scientifica, 2012
There are two sources of cholesterol: endogenous (biliary) and exogenous (dietary) in human organism. Biliary cholesterol arrives with cyctic and. hepatic bile in small intestine and. is mixed, with dietary cholesterol.
YA. L. Tyuryumin, V. A. Shanturov, E. E. Tyuryumina   +2 more
doaj  

Unravelling the role of bilirubin metabolism in gallstone formation: a genetic and metabolic perspective

Egyptian Liver Journal
Gallstone disease is a widespread health issue driven by genetic, metabolic, and environmental factors. Among its types, pigment stones, primarily composed of bilirubin, arise due to disruptions in bilirubin metabolism.
Jashwanth Balu, Sanjana Murali, Pradeep Narahari Ram, R B Devi Krishna, Nandini Krishnamurthy, Shanthi Vijayaraghavan, Rajeshkumar Shanmugam, Andrea Mary Francis   +7 more
doaj   +1 more source

The Effect of Biliary Sphincterotomy on Serum Cholesterol Levels in Postcholecystectomy Patients: A Pilot Study

Canadian Journal of Gastroenterology, 2007
BACKGROUND: Cholesterol, in the form of bile salts, is reabsorbed from the small intestine via the enterohepatic circulation. Biliary sphincterotomy increases the delivery of bile to the terminal ileum. If the absorptive capacity is exceeded, cholesterol
Waleed M Alazmi, Evan L Fogel, James L Watkins, Lee McHenry, Stuart Sherman, Glen A Lehman   +5 more
doaj   +1 more source

Pharmacokinetic modeling of enterohepatic circulation of mycophenolic acid in renal transplant recipients.

, 2014
Several factors contribute to mycophenolic acid (MPA) between-patient variability. Here we characterize the metabolic pathways of MPA and quantify the effect of combining genetic polymorphism of multidrug-resistant-associated protein-2, demographics ...
Andreu, Franc, Kuypers, Dirk R, Oppenheimer, Federico, Caldés, Ana, Sanchez-Plumed, Jaime, Torras, Joan, Colom, Helena, Brunet, Mercè, Ekberg, Henrik, Grinyó, Josep M, Lloberas, Núria, Gentil, Miguel A   +11 more
core   +1 more source

EffectQ1: Please confirm the edits made to the article title are correct. of Enterohepatic Circulation on the Accumulation of Per- and Polyfluoroalkyl Substances: Evidence from Experimental and Computational Studies

, 2022
The pharmacokinetic characteristics of per- and polyfluoroalkyl substances (PFAS) affect their distribution and bioaccumulation in biological systems. The enterohepatic circulation leads to reabsorption of certain chemicals from bile back into blood and ...
Yawei Wang, Ling Wang, Guangliang Liu, Zhen Zhou (184390), Jie Zhang (64655), Cuiyun Wei, Zhe Hu, Jie Zhang, Jie Li, Ling Wang (56577), Yawei Wang (1445449), Huiming Cao (602566), Huiming Cao, Thanh Wang (1592713), Thanh Wang, Zhen Zhou, Zhe Hu (787283), Jie Li (15030), Cuiyun Wei (12065654), Guangliang Liu (1319427), Yong Liang (131898), Yong Liang   +21 more
core   +1 more source

A Physiology-Based Model of Bile Acid Distribution and Metabolism Under Healthy and Pathologic Conditions in Human BeingsSummary

Cellular and Molecular Gastroenterology and Hepatology, 2020
Background & Aims: Disturbances of the enterohepatic circulation of bile acids (BAs) are seen in a number of clinically important conditions, including metabolic disorders, hepatic impairment, diarrhea, and gallstone disease.
Veronika Voronova, Victor Sokolov, Amani Al-Khaifi, Sara Straniero, Chanchal Kumar, Kirill Peskov, Gabriel Helmlinger, Mats Rudling, Bo Angelin   +8 more
doaj   +1 more source

Gastrointestinal luminal polyamines: cellular accumulation and enterohepatic circulation

, 1990
The concentration of polyamines contained in the lumen of the gut was quantified. The duodenum and jejunum of the rat contained 2-3 mM putrescine and 1-2 mM cadaverine, whereas in the ileum and colon the concentration of these polyamines was ...
D. L. Osborne, E. R. Seidel
core   +1 more source

Evolution of substrate specificity for the bile salt transporter ASBT (SLC10A2)[S]

Journal of Lipid Research, 2012
The apical Na+-dependent bile salt transporter (ASBT/SLC10A2) is essential for maintaining the enterohepatic circulation of bile salts. It is not known when Slc10a2 evolved as a bile salt transporter or how it adapted to substantial changes in bile salt ...
Daniël A. Lionarons, James L. Boyer, Shi-Ying Cai   +2 more
doaj   +1 more source

Hepatic overexpression of Abcb11 in mice promotes the conservation of bile acids within the enterohepatic circulation

, 2013
Henkel AS, Gooijert KE, Havinga R, Boverhof R, Green RM, Verkade HJ. Hepatic overexpression of Abcb11 in mice promotes the conservation of bile acids within the enterohepatic circulation.
Havinga, Rick, Boverhof, Renze, Gooijert, Karin E. R., Verkade, Henkjan J., Henkel, Anne S., Verkade, Henkjan J.; id_orcid, Green, Richard M.   +6 more
core   +1 more source