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Neonatal Hyperbilirubinemia in Uganda: Mechanisms, Clinical Consequences, and Health-System Challenges. [PDF]

open access: yesPediatric Health Med Ther
Hamdi MY   +9 more
europepmc   +1 more source
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Enterohepatic Circulation of Urobilinogen

Nature, 1964
THE bacteria of the large bowel reduce bile bilirubin to colourless, Ehrlich-positive chromogens, collectively termed urobilinogen1. It has been stated that urobilinogen is partly re-absorbed from the colon, and afterwards re-excreted in the bile, and, to a lesser degree, in the urine2.
R, LESTER, R, SCHMID
openaire   +2 more sources

Enterohepatic circulation in the rat

Gastroenterology, 1985
Several compounds, in particular bile acids, undergo enterohepatic circulation (EHC). Limited data are available on the pathophysiologic aspects of this circulation. In the present study we describe a surgical technique in rats that allows a long-term, reversible interruption of the EHC and monitoring of peripheral blood levels without direct surgical ...
KUIPERS, F   +5 more
openaire   +3 more sources

Enterohepatic Circulation

Clinical Pharmacokinetics, 2002
Enterohepatic recycling occurs by biliary excretion and intestinal reabsorption of a solute, sometimes with hepatic conjugation and intestinal deconjugation. Cycling is often associated with multiple peaks and a longer apparent half-life in a plasma concentration-time profile.
Roberts, M. S.   +3 more
openaire   +3 more sources

Modeling Enterohepatic Circulation

Current Pharmacology Reports, 2017
The objective of the current analysis is to review the anatomy and physiology of the enterohepatic circulation (EHC); describe how those intricacies affect drug concentration profiles; present various pharmacokinetic models used in the literature to describe EHC concentration-time data; and provide a categorization of these models based on common ...
Malek Okour, Richard C. Brundage
openaire   +1 more source

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