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The pharmacokinetic characteristics of per- and polyfluoroalkyl substances (PFAS) affect their distribution and bioaccumulation in biological systems. The enterohepatic circulation leads to reabsorption of certain chemicals from bile back into blood and ...
Huiming Cao +2 more
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Absorption and enterohepatic circulation of baicalin in rats
Life Sciences, 2005Pharmacokinetics of baicalin, in form of its parent drug (BG) and conjugated metabolites (BGM), were studied following intravenous and oral administration of baicalin to intact rats. The enterohepatic circulation of BG and BGM was also assessed in a linked-rat model.
Jie, Xing, Xiaoyan, Chen, Dafang, Zhong
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Metabolic consequences of ileal interruption of the enterohepatic circulation of bile acids [PDF]
The enterohepatic circulation of bile acids comprises a tightly regulated process of hepatic bile acid secretion, intestinal reabsorption and transport back to the liver.
Ivo P Van De Peppel +2 more
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Nuclear Receptor Control of Enterohepatic Circulation [PDF]
Abstract Enterohepatic circulation is responsible for the capture of bile acids and other steroids produced or metabolized in the liver and secreted to the intestine, for reabsorption back into the circulation and transport back to the liver.
Gonzalez FJ.
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Bile acids (BAs), which are synthesized in the liver and cycled in the enterohepatic circulation, have been recognized as signaling molecules by activating their receptors in the intestine and liver.
Yi Shao, Ming-Wei Zhong, Sanyuan Hu
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Data source: Supplementary data, https://doi.org/10.1016/j.scitotenv.2024.173161Enterohepatic circulation has been reported to play a significant role in the bioaccumulation of PFASs.
Xinyi Cui, Albert L Juhasz
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Enterohepatic circulation in the rat
Gastroenterology, 1985Several compounds, in particular bile acids, undergo enterohepatic circulation (EHC). Limited data are available on the pathophysiologic aspects of this circulation. In the present study we describe a surgical technique in rats that allows a long-term, reversible interruption of the EHC and monitoring of peripheral blood levels without direct surgical ...
KUIPERS, F +5 more
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Enterohepatic Circulation of Urobilinogen
Nature, 1964THE bacteria of the large bowel reduce bile bilirubin to colourless, Ehrlich-positive chromogens, collectively termed urobilinogen1. It has been stated that urobilinogen is partly re-absorbed from the colon, and afterwards re-excreted in the bile, and, to a lesser degree, in the urine2.
R, LESTER, R, SCHMID
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THE ENTEROHEPATIC CIRCULATION OF THYROXINE
Journal of Endocrinology, 1972SUMMARY A quantitative investigation was made of the enterohepatic circulation of endogenous thyroxine (T4) in the rat. Control and cold-acclimated rats were maintained on a low iodine diet and water containing 125I-labelled iodide of known specific activity for 4 weeks. Faeces were then collected over a 3-day period.
V A, Galton, B C, Nisula
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Enterohepatic circulation of sulindac and metabolites
Clinical Pharmacology and Therapeutics, 1983Four subjects were studied by continuous intraduodenal sampling to establish the existence and determine the extent of enterohepatic recirculation of sulindac and its sulfide and sulfone metabolites. Sulindac, 200 mg by mouth, was given every 12 hr for 7 days.
C A, Dujovne +5 more
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