Results 151 to 160 of about 13,632 (184)
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Enterohepatic Circulation of Drugs
The Journal of Clinical Pharmacology, 1989Review on the processes of biliary excretion and enterohepatic circulation of drugs and the pharmacokinetic and pharmacodynamic consequences ...
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Crohn's disease and the enterohepatic circulation
Medical Hypotheses, 1981Crohn's disease is a chronic inflammatory process which may affect any part of the alimentary tract. This cause is unknown. Overall the distribution of the lesions coincides with that of the enterohepatic circulation. A possible causative agent is a metabolic or ingested substance excreted into the bile in the form of a polar and inactive conjugates ...
H, Nyhlin, M A, Eastwood
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2020
The term “Enterohepatic circulation” (EHC) refers to the circulation of metabolites from the intestine to the liver and back to the intestine. Since the first use of the term in 1923, understanding of the detailed physiology, microanatomy, and biochemistry, and of interactions between organs and tissues, has grown dramatically.
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The term “Enterohepatic circulation” (EHC) refers to the circulation of metabolites from the intestine to the liver and back to the intestine. Since the first use of the term in 1923, understanding of the detailed physiology, microanatomy, and biochemistry, and of interactions between organs and tissues, has grown dramatically.
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Modeling Enterohepatic Circulation
Current Pharmacology Reports, 2017The objective of the current analysis is to review the anatomy and physiology of the enterohepatic circulation (EHC); describe how those intricacies affect drug concentration profiles; present various pharmacokinetic models used in the literature to describe EHC concentration-time data; and provide a categorization of these models based on common ...
Malek Okour, Richard C. Brundage
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Enterohepatic Circulation of Tetracycline in Rats
Journal of Pharmaceutical Sciences, 1975The absorption of tetracycline hydrochloride excreted in the bile of rats was evaluated using the insitu intestinal preparation. For comparative purposes, the absorption of the drug from an aqueous solution having the same pH as that of the bile was also determined.
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The enterohepatic circulation in glutethimide intoxication
Clinical Pharmacology & Therapeutics, 1970The role of the enterohepatic circulation in glutethimide (Doriden) metabolism and toxicity was investigated in patients and dogs undergoing biliary drailwge. Bile collected after the oral or parenteral administration of glutethimide contained insignificant quantities of active and unmetabolized drug. Oral administration of glutethimide both before and
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1983
The principal components of bile are the conjugated bile acids, cholesterol, and phospholipid, but in addition to these major components there is a vast array of minor components. Some of these are waste products of metabolism excreted by secretion in the bile, for example, bilirubin and the bile pigments.
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The principal components of bile are the conjugated bile acids, cholesterol, and phospholipid, but in addition to these major components there is a vast array of minor components. Some of these are waste products of metabolism excreted by secretion in the bile, for example, bilirubin and the bile pigments.
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Interruption of the enterohepatic circulation of phenprocoumon by cholestyramine
Clinical Pharmacology & Therapeutics, 1977The effect of cholestyramine (12 gm/day divided into 3 doses) on the pharmacokinetics and pharmacodynamics of a single intravenous dose (30 mg) of phenprocoumon was studied in 6 normal subjects. Cholestyramine treatment led to an increase in the rate of elimination of phenprocoumon in all. Total clearance increased 1.5‐ to 2‐fold.
T, Meinertz +4 more
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Canine bile acid enterohepatic circulation
Steroids, 1982The enterohepatic circulation (EHC) of bile acids has been studied in fasting dogs with portacaval shunt maintained in the steady state. In such animals the rate of EHC is proportional to systemic blood bile acid concentration. Bile acid EHC was irregular (20 to 100% variation) when measured at 15 minute or hourly intervals.
W T, Beher +4 more
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Quantitation of the Enterohepatic Circulation of Retinol in the Rat
The Journal of Nutrition, 1988Studies were done to determine whether vitamin A is reabsorbed in the enterohepatic circulation in forms that can be reutilized by the body for vision and reproduction. Micelles containing [11,12(n)-3H]retinol were administered orally to mesenteric lymph duct-cannulated rats.
J D, Ribaya-Mercado +2 more
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