Results 181 to 190 of about 603,469 (215)
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1975
Substances are said to undergo an enterohepatic circulation (EHC) when they are excreted into the bile, pass into the lumen of the intestine, are reabsorbed and then return to the liver via the circulation. Many endogenous and exogenous substances can undergo an EHC.
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Substances are said to undergo an enterohepatic circulation (EHC) when they are excreted into the bile, pass into the lumen of the intestine, are reabsorbed and then return to the liver via the circulation. Many endogenous and exogenous substances can undergo an EHC.
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1983
The principal components of bile are the conjugated bile acids, cholesterol, and phospholipid, but in addition to these major components there is a vast array of minor components. Some of these are waste products of metabolism excreted by secretion in the bile, for example, bilirubin and the bile pigments.
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The principal components of bile are the conjugated bile acids, cholesterol, and phospholipid, but in addition to these major components there is a vast array of minor components. Some of these are waste products of metabolism excreted by secretion in the bile, for example, bilirubin and the bile pigments.
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Pharmacokinetics of Drugs Subject to Enterohepatic Circulation
Journal of Pharmaceutical Sciences, 1979The influence of the changes in biliary excretion and reabsorption rates on the pharmacokinetics of drugs subject to enterohepatic circulation was examined analytically. A recently proposed two-compartment model with drug elimination occurring in each compartment was adapted to represent the body and the GI tract.
H S, Chen, J F, Gross
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Interruption of the enterohepatic circulation of phenprocoumon by cholestyramine
Clinical Pharmacology & Therapeutics, 1977The effect of cholestyramine (12 gm/day divided into 3 doses) on the pharmacokinetics and pharmacodynamics of a single intravenous dose (30 mg) of phenprocoumon was studied in 6 normal subjects. Cholestyramine treatment led to an increase in the rate of elimination of phenprocoumon in all. Total clearance increased 1.5‐ to 2‐fold.
T, Meinertz +4 more
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Canine bile acid enterohepatic circulation
Steroids, 1982The enterohepatic circulation (EHC) of bile acids has been studied in fasting dogs with portacaval shunt maintained in the steady state. In such animals the rate of EHC is proportional to systemic blood bile acid concentration. Bile acid EHC was irregular (20 to 100% variation) when measured at 15 minute or hourly intervals.
W T, Beher +4 more
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Quantitation of the Enterohepatic Circulation of Retinol in the Rat
The Journal of Nutrition, 1988Studies were done to determine whether vitamin A is reabsorbed in the enterohepatic circulation in forms that can be reutilized by the body for vision and reproduction. Micelles containing [11,12(n)-3H]retinol were administered orally to mesenteric lymph duct-cannulated rats.
J D, Ribaya-Mercado +2 more
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Pathophysiology of the enterohepatic circulation of bile acids
1979Progress in research on bile acid metabolism has been accelerated by new sensitive methods for detecting individual bile acids in biologic fluids. The most important advances involve the pathophysiologic basis for formation of cholesterol gallstones, the disturbed secretion and synthesis of bile acids in cholestasis and liver disease, and the ...
S, Matern, W, Gerok
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Cysteinyl leukotrienes undergo enterohepatic circulation
Prostaglandins, Leukotrienes and Medicine, 1986Abstract Enterohepatic circulation is an important mechanism responsible for extension of the biological half-lives of many endogenous compounds and xenobiotics (1). Cysteinyl leukotrienes play an important role in lethal endotoxin action (2) and in tissue trauma (3).
C, Denzlinger +7 more
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Chemistry and Enterohepatic Circulation of Bile Acids† ‡ § ¶ # ‖ ** †† ‡‡ §§ ¶¶ ‖‖ ##
Hepatology, 1984A brief review is given of the chemistry of bile acids, emphasizing the relationship between chemical structure, physical properties and enterohepatic cycling of the major primary and secondary bile acids. Features of the enterohepatic circulation of primary and secondary bile acids in man are summarized.
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The Enterohepatic Circulation of Bile Acids in Man
Clinics in Gastroenterology, 1976The enterohepatic circulation of bile acids may now be described in its broad outlines. Methodology presently available appears sufficient for overall characterization in health and disease. The challenge of the future is to gain insight into the control of the enterohepatic circulation so that new therapeutic approaches to liver, biliary and ...
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