Bile Acids Transporters of Enterohepatic Circulation for Targeted Drug Delivery [PDF]
Molecules, 2022 Bile acids (BAs) are important steroidal molecules with a rapidly growing span of applications across a variety of fields such as supramolecular chemistry, pharmacy, and biomedicine.
Robin Durník +2 more
exaly +5 more sources
Effect of different bile acids on the intestine through enterohepatic circulation based on FXR [PDF]
Gut Microbes, 2021 Farnesoid X receptor (FXR) is a nuclear receptor for bile acids (BAs) that is widely expressed in the intestine, liver and kidney. FXR has important regulatory impacts on a wide variety of metabolic pathways (such as glucose, lipid, and sterol metabolism)
Chengcheng Zhang, Hua Cao, Qishi Che
exaly +3 more sources
Pharmacokinetics and enterohepatic circulation of jervine, an antitumor steroidal alkaloid from Veratrum nigrum in rats [PDF]
Journal of Pharmaceutical Analysis, 2019 Jervine, a novel steroidal alkaloid from Veratrum nigrum L., exhibits both antitumor effect and potential toxicity. The aim of study was to characterize the pharmacokinetic behaviors and enterohepatic circulation of jervine in rats.
Bingjing Zheng +4 more
doaj +3 more sources
Liver-targeted delivery of insulin-loaded nanoparticles via enterohepatic circulation of bile acids [PDF]
Drug Delivery, 2018 Liver is the primary acting site of insulin. In this study, we developed innovative nanoparticles for oral and liver-targeted delivery of insulin by using enterohepatic circulation of bile acids.
Zhe Zhang +3 more
doaj +3 more sources
Bifidobacterium species associated with breastfeeding alleviate neonatal hyperbilirubinaemia via the gut microbiota-α-linolenic and linoleic acid metabolism-enterohepatic circulation axis [PDF]
MicrobiomeBackground Recent studies suggest a role of gut microbiota in the development of neonatal hyperbilirubinemia, with bifidobacteria showing promise in alleviating symptoms.
Chunxiu Lin +6 more
doaj +3 more sources
Enterohepatic Circulation and Pharmacokinetics of Genistin and Genistein in Rats [PDF]
ACS Omega, 2019 Genistin and its aglycone genistein of isoflavone are naturally occurring in plants. The aim of this study is to develop an experimental animal model of enterohepatic circulation to investigate the metabolic biotransformation of genistin and genistein in
Ya-Yu Yang, Tung-Hu Tsai
doaj +3 more sources
The Supplementation of FloraMax-B11 Did Not Affect the Bile Acid Neosynthesis and the Enterohepatic Circulation in Broiler Chickens [PDF]
Animals, 2022 Most probiotics possess bile salt hydrolase enzymes and may increase bile acid excretion and negatively affect fat digestion and absorption. Therefore, the study objective was to determine the time course effects of a commercial probiotic (P) FloraMax ...
Kouassi R. Kpodo +4 more
doaj +2 more sources
Sustained suppression of enterohepatic circulation of mycophenolic acid by antimicrobial‐associated diarrhea in a kidney transplant recipient with Crohn's disease: A case report [PDF]
Clinical Case Reports, 2022 Mycophenolic acid (MPA) undergoes enterohepatic circulation. A kidney transplant patient on mycophenolate mofetil was treated with tazobactam/piperacillin for pyelonephritis, and developed antimicrobial‐associated diarrhea.
Ryota Tanaka +6 more
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Acta Pharmaceutica Sinica B, 2012 Thienorphine (TNP) is a new partial opioid agonist currently developed as a promising drug candidate with the intended clinical indication for the treatment of opioid dependence.
Jingting Deng +4 more
doaj +2 more sources
Pharmacogenetics of Drug Transporters in the Enterohepatic Circulation [PDF]
Pharmacogenomics, 2011 This article summarizes the impact of the pharmacogenetics of drug transporters expressed in the enterohepatic circulation on the pharmacokinetics and pharmacodynamics of drugs. The role of pharmacogenetics in the function of drug transporter proteins in vitro is now well established and evidence is rapidly accumulating from in vivo pharmacokinetic ...
Stieger Bruno, Meier Peter J
openaire +4 more sources