Results 21 to 30 of about 13,632 (184)
Sustained hyperuricemia disrupts enterohepatic circulation through 12α-hydroxy BA and gut microbiota [PDF]
Frontiers in MicrobiologyHyperuricemia (HUA) has become a worldwide health issue, drawing increasing public attention. This study aimed to elucidate the roles of bile acids (BAs) and their associations with gut microbiota in a HUA rat model. We established normal control (N) and
Tong Zou +13 more
doaj +2 more sources
Pharmacokinetics and Enterohepatic Circulation of 2-(Quinoline-8-carboxamido)benzoic Acid (2-QBA) in Mice [PDF]
PharmaceuticsThe quinoline alkaloid 2-(quinoline-8-carboxamido)benzoic acid (2-QBA), which is isolated from Aspergillus sp. SCSIO06786, a deep sea-derived fungus, has been suggested as a therapeutic candidate for the treatment of Parkinson’s disease.
Ji-Hyeon Jeon +6 more
doaj +2 more sources
Metabolic effects of intestinal absorption and enterohepatic cycling of bile acids
Acta Pharmaceutica Sinica B, 2015 The classical functions of bile acids include acting as detergents to facilitate the digestion and absorption of nutrients in the gut. In addition, bile acids also act as signaling molecules to regulate glucose homeostasis, lipid metabolism and energy ...
Courtney B. Ferrebee, Paul A. Dawson
doaj +2 more sources
Model-Based Prediction of Plasma Concentration and Enterohepatic Circulation of Total Bile Acids in Humans. [PDF]
CPT Pharmacometrics Syst Pharmacol, 2018 Bile acids released postprandially can modify the rate and extent of lipophilic compounds’ absorption. This study aimed to predict the enterohepatic circulation (EHC) of total bile acids (TBAs) in response to caloric intake from their spillover in plasma.
Guiastrennec B +5 more
europepmc +2 more sources
Altered Bile Acid Transport in Liver Disease [PDF]
BiomedicinesBackground/Objectives: Bile acids, synthesized from cholesterol in the liver, are amphipathic molecules that play an integral role in lipid digestion and absorption, while also serving as systemic endocrine hormones.
Sarah Cayton, Lindsay C. Czuba
doaj +2 more sources
Cellular and Molecular Gastroenterology and Hepatology, 2021 Background & Aims: cAMP responsive element-binding protein 3 like 3 (CREB3L3) is a membrane-bound transcription factor involved in the maintenance of lipid metabolism in the liver and small intestine. CREB3L3 controls hepatic triglyceride and glucose
Yoshimi Nakagawa +18 more
doaj +1 more source
Enterohepatic Circulation of Bilirubin [PDF]
Nature, 1961 THE enterohepatic circulation of bile pigment has been the subject of protracted debate. Recirculation of bilirubin, and its bacterial reduction products, the urobilinoids, has been postulated and denied1. The availability of bilirubin labelled with carbon-14 in this Laboratory2 has obviated many of the problems previously inherent in the study of ...
R, LESTER, J D, OSTROW, R, SCHMID
openaire +2 more sources
Frontiers in Pharmacology, 2022 Oleandrin is a highly lipid-soluble cardiac glycoside isolated from the plant Nerium oleander (Apocynaceae) and is used as a traditional herbal medicine due to its excellent pharmacological properties. It is widely applied for various disease treatments,
Jinxiao Zhai +4 more
doaj +1 more source
Exploitation of Bile Acid Transport Systems in Prodrug Design
Molecules, 2007 The enterohepatic circulation of bile acids is one of the most efficient recycling routes in the human body. It is a complex process involving numerous transport proteins, which serve to transport bile acids from the small intestine into portal ...
Elina Sievänen
doaj +1 more source
Role of Saccharomyces boulardii in Reduction of Neonatal Hyperbilirubinemia [PDF]
Journal of Clinical and Diagnostic Research, 2016 Introduction: Probiotics are known to reduce the severity of hyperbilirubinemia. Aim: This study was done to evaluate the effect of probiotic on neonatal hyperbilirubinemia in term neonates. Materials and Methods: A total of 181 healthy term neonates
V. Suganthi, A. Gokul Das
doaj +1 more source