Exploitation of Bile Acid Transport Systems in Prodrug Design
Molecules, 2007 The enterohepatic circulation of bile acids is one of the most efficient recycling routes in the human body. It is a complex process involving numerous transport proteins, which serve to transport bile acids from the small intestine into portal ...
Elina Sievänen
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Recent advances in understanding and managing cholestasis [version 1; referees: 2 approved]
F1000Research, 2016 Cholestatic liver diseases are hereditary or acquired disorders with impaired hepatic excretion and enterohepatic circulation of bile acids and other cholephiles.
Martin Wagner, Michael Trauner
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Survival of gastric and enterohepatic Helicobacter spp. in water: implications for transmission [PDF]
, 2008 Part of the reason for rejecting aquatic environments as possible vectors for the transmission of Helicobacter pylori has been the preference of this microorganism to inhabit the human stomach and hence use a direct oral-oral route for transmission.
Almeida, Carina +11 more
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, 2021 Broadly speaking, enterohepatic recycling (or enterohepaticcirculation) involves the circulation of metabolized and non-metabolizedcompounds (including physiologic compounds and xenobiotics) between theintestine and the liver.
Bellera, Carolina Leticia +3 more
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Role of Saccharomyces boulardii in Reduction of Neonatal Hyperbilirubinemia [PDF]
Journal of Clinical and Diagnostic Research, 2016 Introduction: Probiotics are known to reduce the severity of hyperbilirubinemia. Aim: This study was done to evaluate the effect of probiotic on neonatal hyperbilirubinemia in term neonates. Materials and Methods: A total of 181 healthy term neonates
V. Suganthi, A. Gokul Das
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Effects of interrupting the enterohepatic circulation in amatoxin intoxications [PDF]
Interruption of the enterohepatic circulation is regarded as an effective way to treat patients with amatoxin poisoning. Nonetheless, its effectiveness has not yet been systematically evaluated.
Patrick F. van Rheenen (4666621) +6 more
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Bile Acids: Major Regulator of the Gut Microbiome
Microorganisms, 2022 Bile acids are synthesized from cholesterol and play an important role in regulating intestinal microflora. The different degrees of hydrophobicity and acidity of individual bile acids may affect their antimicrobial properties.
Chihyeok An +14 more
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Reversal of surgical biliary diversion with ileal bile acid transport inhibitors: A new chapter in progressive familiar intrahepatic cholestasis type 1 management? [PDF]
JPGN RepAbstract Progressive Familial Intrahepatic Cholestasis type 1 (PFIC1) is a multisystem disorder. Although liver transplant (LT) resolves the hepatic disease, post‐LT complications may occur, including severe enteropathy and graft steatosis caused by impaired bile acids handling by the native intestine.
Botelho T +6 more
europepmc +2 more sources
Modulating the enterohepatic circulation in cholestatic and metabolic liver diseases:Therapeutic perspectives [PDF]
Bile salts are synthesized in the liver and temporarily stored in the gall bladder, before they are released in the small intestine upon food intake. Here, they help with the digestion and absorption of food and nutrients.
Kunst, R.F.
core +8 more sources
Journal of Lipid Research, 1993 Cholesterol 7 alpha-hydroxylase, the rate-determining enzyme in the bile acid biosynthesis pathway, is regulated in a negative feedback manner by hydrophobic bile salts returning to the liver via the portal circulation.
MP Jones +5 more
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