Results 41 to 50 of about 2,925 (189)
Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation. [PDF]
, 2015 Exposure to high levels of ionizing radiation (IR) leads to debilitating and dose-limiting gastrointestinal (GI) toxicity. Using three-dimensional mouse crypt culture, we demonstrated that p53 target PUMA mediates radiation-induced apoptosis via a cell ...
Cramer, Julie M +14 more
core +2 more sources
PLoS Neglected Tropical Diseases, 2022 Enterotoxigenic Escherichia coli (ETEC) is a primary causative agent of diarrhea in travelers and young children in low-to-middle-income countries (LMICs).
Emily M Smith +4 more
doaj +1 more source
Molecular Basis and Differentiation-Associated Alterations of Anion Secretion in Human Duodenal Enteroid Monolayers [PDF]
, 2018 Background & Aims: Human enteroids present a novel tool to study human intestinal ion transport physiology and pathophysiology. The present study describes the contributions of Cl- and HCO3 - secretion to total cyclic adenosine monophosphate (cAMP ...
Avula, L.R. (Leela Rani) +6 more
core +5 more sources
Stem Cell-Derived Models of Viral Infections in the Gastrointestinal Tract
Viruses, 2018 Studies on the intestinal epithelial response to viral infection have previously been limited by the absence of in vitro human intestinal models that recapitulate the multicellular complexity of the gastrointestinal tract.
Wyatt E. Lanik +4 more
doaj +1 more source
Di-san junyi daxue xuebao, 2020 Objective To compare the potentiality and characteristics of different intestinal epithelial cell (IEC) lines to grow into enteroids when cultured in 3D system in order to provide experimental basis for the cultivation of enteroids by IECs. Methods Three
OU Jing, XU Zhenni, LIU Dengqun
doaj +1 more source
GUCY2C maintains intestinal LGR5+ stem cells by opposing ER stress [PDF]
, 2017 Long-lived multipotent stem cells (ISCs) at the base of intestinal crypts adjust their phenotypes to accommodate normal maintenance and post-injury regeneration of the epithelium.
Kraft, Crystal +5 more
core +2 more sources
Highly conserved type 1 pili promote enterotoxigenic E. coli pathogen-host interactions [PDF]
, 2017 Enterotoxigenic Escherichia coli (ETEC), defined by their elaboration of heat-labile (LT) and/or heat-stable (ST) enterotoxins, are a common cause of diarrheal illness in developing countries.
Begum, Yasmin Ara +7 more
core +3 more sources
Effects of short-chain fatty acids on intestinal function in an enteroid model of hypoxia
Frontiers in Physiology, 2022 The healthy GI tract is physiologically hypoxic, but this may be perturbed by certain acute and chronic stressors that reduce oxygen availability systemically.
Sarah C. Pearce +2 more
doaj +1 more source
Proteomic Profiling of Enteroid Cultures Skewed Towards Development of Specific Epithelial Lineages [PDF]
, 2018 Recently, three‐dimensional small intestinal organoids (enteroids) have been developed from cultures of intestinal stem cells which differentiate in vitro to generate all the differentiated epithelial cell types associated with the intestine and mimic ...
Aoki-Yoshida +28 more
core +5 more sources
A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis [PDF]
Journal of Visualized Experiments, 2019 Necrotizing enterocolitis (NEC) is a devastating disease of newborn infants. It is characterized by multiple pathophysiologic alterations in the human intestinal epithelium, leading to increased intestinal permeability, impaired restitution, and increased cell death.
Guillermo J, Ares +4 more
openaire +2 more sources