Concise Review: The Potential Use of Intestinal Stem Cells to Treat Patients With Intestinal Failure. [PDF]
, 2016 : Intestinal failure is a rare life-threatening condition that results in the inability to maintain normal growth and hydration status by enteral nutrition alone.
Dunn, James CY +3 more
core +1 more source
Age-Specific ADME Gene Expression in Infant Intestinal Enteroids. [PDF]
Mol PharmIn childhood, developmental changes and environmental interactions highly affect orally dosed drug disposition across the age range. To optimize dosing regimens and ensure safe use of drugs in pediatric patients, understanding this age-dependent biology is necessary. In this proof-of-concept study, we aimed to culture age-specific enteroids from infant
Streekstra EJ +12 more
europepmc +8 more sources
Intestinal epithelial replacement by transplantation of cultured murine and human cells into the small intestine. [PDF]
, 2019 Adult intestinal epithelial stem cells are a promising resource for treatment of intestinal epithelial disorders that cause intestinal failure and for intestinal tissue engineering.
Cho, Yonghoon +9 more
core +2 more sources
Production of tissue-engineered intestine from expanded enteroids [PDF]
Journal of Surgical Research, 2016 Short bowel syndrome is a life-threatening condition with few solutions. Tissue-engineered intestine (TEI) is a potential treatment, but donor intestine is a limiting factor. Expanded epithelial surrogates termed enteroids may serve as a potential donor source.To produce TEI from enteroids, crypts were harvested from mice and enteroid cultures ...
Barrett P. Cromeens +5 more
openaire +2 more sources
Fenofibrate reduces glucose-induced barrier dysfunction in feline enteroids
Scientific Reports, 2023 AbstractDiabetes mellitus (DM) is a common chronic metabolic disease in humans and household cats that is characterized by persistent hyperglycemia. DM is associated with dysfunction of the intestinal barrier. This barrier is comprised of an epithelial monolayer that contains a network of tight junctions that adjoin cells and regulate paracellular ...
Crawford, Charles +7 more
openaire +5 more sources
Development of Functional Microfold (M) Cells from Intestinal Stem Cells in Primary Human Enteroids. [PDF]
, 2016 Background & aimsIntestinal microfold (M) cells are specialized epithelial cells that act as gatekeepers of luminal antigens in the intestinal tract.
Dunn, James CY +11 more
core +4 more sources
Intestinal Stem Cell-Derived Enteroids From Morbidly Obese Patients Preserve Obesity-Related Phenotypes: Elevated Glucose Absorption and Gluconeogenesis [PDF]
, 2021 OBJECTIVE: The mechanisms behind the efficacy of bariatric surgery (BS) for treating obesity and type 2 diabetes, particularly with respect to the influence of the small bowel, remain poorly understood.
Baetz, Nicholas W +10 more
core +2 more sources
Evaluating Shigella flexneri Pathogenesis in the Human Enteroid Model [PDF]
Infection and Immunity, 2019 The enteric pathogen Shigella is one of the leading causes of moderate-to-severe diarrhea and death in young children in developing countries. Transformed cell lines and animal models have been widely used to study Shigella pathogenesis.
Ranganathan, Sridevi +5 more
openaire +2 more sources
Put Some Guts into It: Intestinal Organoid Models to Study Viral Infection
Viruses, 2020 The knowledge about enteric viral infection has vastly increased over the last eight years due to the development of intestinal organoids and enteroids that suppose a step forward from conventional studies using cell lines.
Inés García-Rodríguez +3 more
doaj +1 more source
Radiation mitigation of the intestinal acute radiation injury in mice by 1-[(4-nitrophenyl)sulfonyl]-4-phenylpiperazine. [PDF]
, 2020 The objective of the study was to identify the mechanism of action for a radiation mitigator of the gastrointestinal (GI) acute radiation syndrome (ARS), identified in an unbiased high-throughput screen.
Alli, Claudia +11 more
core +1 more source