Genomic Diversity of Enterotoxigenic Strains of Bacteroides fragilis. [PDF]
PLoS ONE, 2016 Enterotoxigenic (ETBF) strains of Bacteroides fragilis are the subset of strains that secrete a toxin called fragilysin (Bft). Although ETBF strains are known to cause diarrheal disease and have recently been associated with colorectal cancer, they have ...
Jessica V Pierce, Harris D Bernstein
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Enterotoxigenic and nontoxigenic Bacteroides fragilis strains isolated in Brazil [PDF]
Memorias do Instituto Oswaldo Cruz, 2008 The presence of enterotoxigenic Bacteroides fragilis and nontoxigenic B. fragilis (NTBF) among 109 strains isolated from 1980-2008 in Brazil were investigated by PCR.
Karla R Miranda +14 more
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Detection of enterotoxigenic Bacteroides fragilis in patients with ulcerative colitis [PDF]
Gut Pathogens, 2017 Purpose Ulcerative colitis (UC) as a type of inflammatory bowel disease (IBD), presumed to occur as a consequence of increased immune responses to intestinal microbiota in genetically susceptible individuals.
Samin Zamani +8 more
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Gut Microbes, 2020 The enrichment of Enterotoxigenic Bacteroides fragilis (ETBF) has been identified in CRC patients and associated with worse prognosis. Cancer stem cells (CSCs) play essential roles in CRC development.
Qin Yan Gao +2 more
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Caffeic Acid Phenethyl Ester Administration Reduces Enterotoxigenic Bacteroides fragilis-Induced Colitis and Tumorigenesis [PDF]
ToxinsThe human colonic commensal enterotoxigenic Bacteroides fragilis (ETBF) is associated with chronic colitis and colon cancer. ETBF colonization induces colitis via the Bacteroides fragilis toxin (BFT).
Soonjae Hwang +7 more
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Colonization with enterotoxigenic Bacteroides fragilis is associated with early-stage colorectal neoplasia. [PDF]
PLoS ONE, 2017 BackgroundEnterotoxigenic Bacteroides fragilis (ETBF) is a toxin-producing bacteria thought to possibly promote colorectal carcinogenesis by modulating the mucosal immune response and inducing epithelial cell changes.
Rachel V Purcell +5 more
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A review of the role of enterotoxigenic Bacteroides fragilis in the development of colorectal cancer
Basic & Clinical Cancer ResearchEnterotoxigenic Bacteroides fragilis (ETBF) plays a significant role in the development and progression of colorectal cancer (CRC) through the production of Bacteroides fragilis toxin (BFT). This toxin activates Wnt, NF-κB, and STAT3 signaling pathways,
Abolfazl Jafari-Sales +5 more
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Bacteriophage-mediated restoration of epithelial integrity, DNA damage response, and transcriptomic homeostasis in colon organoids exposed to ETBF and pks + E. coli [PDF]
Scientific ReportsColorectal cancer (CRC)–associated pathobionts such as Enterotoxigenic Bacteroides fragilis (ETBF) and colibactin-producing (pks+) Escherichia coli disrupt epithelial barrier function, promote chronic inflammation, and induce genotoxic stress.
Myoung Hyoun Song +9 more
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Fecal detection of enterotoxigenic Bacteroides fragilis. [PDF]
Eur J Clin Microbiol Infect Dis, 2015 Bacteroides fragilis is a common colonic symbiote of which one subtype, enterotoxigenic Bacteroides fragilis (ETBF), causes inflammatory diarrhea. However, asymptomatic ETBF colonization is common. Through its primary virulence factor, B. fragilis toxin (BFT), ETBF causes asymptomatic, chronic colitis in C57BL/6 mice and increased colon tumorigenesis ...
Chen LA +7 more
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mBio, 2021 Human gut microbes exhibit a spectrum of cooperative and antagonistic interactions with their host and also with other microbes. The major Bacteroides host-targeting virulence factor, Bacteroides fragilis toxin (BFT), is produced as an inactive protoxin ...
Yiqiao Bao +6 more
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