Results 51 to 60 of about 1,444 (144)

KRAS mutations promote the intratumoral colonization of enterotoxigenic bacteroides fragilis in colorectal cancer through the regulation of the miRNA3655/SURF6/IRF7/IFNβ axis

Gut Microbes
KRAS mutations are associated with poor prognosis in colorectal cancer (CRC). Although the association between the gut microbiota and CRC has been extensively documented, it is unclear whether KRAS mutations can regulate the gut microbiota.
Yizhen Chen, Shaolin Liu, Song Tan, Yuanyuan Zheng, Yifan Chen, Changshun Yang, Shengtao Lin, Yulong Mi, Weihua Li   +8 more
doaj   +1 more source

Association of Pre-diagnostic Antibody Responses to Escherichia coli and Bacteroides fragilis Toxin Proteins with Colorectal Cancer in a European Cohort

Gut Microbes, 2021
Experimental evidence has implicated genotoxic Escherichia coli (E. coli) and enterotoxigenic Bacteroides fragilis (ETBF) in the development of colorectal cancer (CRC). However, evidence from epidemiological studies is sparse.
Julia Butt, Mazda Jenab, Jill Werner, Veronika Fedirko, Elisabete Weiderpass, Christina C. Dahm, Anne Tjønneland, Anja Olsen, Marie-Christine Boutron-Ruault, Joseph A. Rothwell, Gianluca Severi, Rudolf Kaaks, Renée Turzanski-Fortner, Krasimira Aleksandrova, Matthias Schulze, Domenico Palli, Valeria Pala, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote, Bas Bueno-de-Mesquita, Carla H. Van Gils, Inger Torhild Gram, Marko Lukic, Núria Sala, María José Sánchez Pérez, Eva Ardanaz, María-Dolores Chirlaque, Richard Palmquist, Thyra Löwenmark, Ruth C Travis, Alicia Heath, Amanda J Cross, Heinz Freisling, Semi Zouiouich, Elom Aglago, Tim Waterboer, David J. Hughes   +37 more
doaj   +1 more source

Progress in the detection of gut microbiota based on microfluidic technology

Interdisciplinary Medicine, Volume 4, Issue 1, January 2026.
Abstract Gut microbiota, a complex microbial community in the human intestine, are vital for digestion, nutrient absorption, and immune regulation, maintaining gut micro‐ecological balance. Accurate detection of its composition, structure, and function is crucial for understanding the relationship between health and disease, early disease diagnosis ...
Yuan Tan, Jiayue Huang, Yi Liu, Xiaofei Lai   +3 more
wiley   +1 more source

Fecal Enterotoxigenic Bacteroides fragilis–Peptostreptococcus stomatis–Parvimonas micra Biomarker for Noninvasive Diagnosis and Prognosis of Colorectal Laterally Spreading Tumor

Frontiers in Oncology, 2021
ObjectiveUp to now, non-invasive diagnosis of laterally spreading tumor (LST) and prediction of adenoma recurrence after endoscopic resection of LSTs is inevitable.
Xiaonan Shen, Jialu Li, Jiaqi Li, Yao Zhang, Xiaobo Li, Yun Cui, Qinyan Gao, Xiaoyu Chen, Yingxuan Chen, Jing-Yuan Fang   +9 more
doaj   +1 more source

Structure, function and latency regulation of a bacterial enterotoxin potentially derived from a mammalian adamalysin/ADAM xenolog [PDF]

, 2011
El pdf del artículo es la versión pre-print.Enterotoxigenic Bacteroides fragilis is the most frequent disease-causing anaerobe in the intestinal tract of humans and livestock and its specific virulence factor is fragilysin, also known as B.
Goulas, Theodoros, Arolas, Joan L., Gomis-Rüth, F. Xavier   +2 more
core   +1 more source

Gut microbiota manipulation as a tool for colorectal cancer management: Recent advances in its use for therapeutic purposes [PDF]

, 2020
Colorectal cancer (CRC) is a multifaceted disease influenced by both environmental and genetic factors. A large body of literature has demonstrated the role of gut microbes in promoting inflammatory responses, creating a suitable microenvironment for the
Amoroso C., Diaz-Basabe A., Facciotti F., Giuffre M. R., Lattanzi G., Perillo F., Strati F.   +6 more
core   +1 more source

Precision Antimicrobial Therapy Against Fusobacterium nucleatum Using Bioengineered Probiotics Expressing Guided Antimicrobial Peptides (gAMPs)

Microbial Biotechnology, Volume 18, Issue 12, December 2025.
We engineered a probiotic using Lactococcus lactis that targets Fusobacterium nucleatum, a cancer‐associated microbe, by secreting guided antimicrobial peptides (gAMPs) binding to the FomA porin protein. This approach inhibits biofilms, preserves microbial diversity and provides a precise, microbiome‐sparing alternative to broad‐spectrum antibiotics ...
Ankan Choudhury, Colin Scano, Allison Barton, Christopher M. Kearney, K. Leigh Greathouse   +4 more
wiley   +1 more source

Drug Discovery and Repurposing Inhibits a Major Gut Pathogen-Derived Oncogenic Toxin

Frontiers in Cellular and Infection Microbiology, 2019
Objective: The human intestinal microbiome plays an important role in inflammatory bowel disease (IBD) and colorectal cancer (CRC) development. One of the first discovered bacterial mediators involves Bacteroides fragilis toxin (BFT, also named as ...
Paul Metz, Paul Metz, Paul Metz, Martijn J. H. Tjan, Martijn J. H. Tjan, Shaoguang Wu, Mehrosh Pervaiz, Susanne Hermans, Aishwarya Shettigar, Cynthia L. Sears, Tina Ritschel, Bas E. Dutilh, Bas E. Dutilh, Annemarie Boleij   +13 more
doaj   +1 more source

Microbe-based management for colorectal cancer

Chinese Medical Journal, 2021
. Colorectal cancer (CRC) is one of the most prevalent, most lethal cancers in the world. Increasing evidence suggests that the intestinal microbiota is closely related to the pathogenesis and prognosis of CRC.
Zi-Yun Gao, Zhe Cui, Yu-Qing Yan, Li-Jun Ning, Zhen-Hua Wang, Jie Hong, Yuan-Yuan Ji   +6 more
doaj   +1 more source

The microbiome in cancer

iMeta, Volume 4, Issue 5, October 2025.
This comprehensive review elucidates the transformative role of the human microbiome in cancer biology, revealing innovative mechanistic insights into the intricate tumor–microbe interactions across diverse organ systems. This work highlights the clinical and translational value of novel microbiome‐based biomarkers for early detection, prognosis, and ...
Anqi Lin, Minying Xiong, Aimin Jiang, Lihaoyun Huang, Hank Z. H. Wong, Suyin Feng, Chunyan Zhang, Yu Li, Li Chen, Hao Chi, Pengpeng Zhang, Bicheng Ye, Hengguo Zhang, Nan Zhang, Lingxuan Zhu, Weiming Mou, Junyi Shen, Kailai Li, Wentao Xu, Haoxuan Ying, Cangang Zhang, Dongqiang Zeng, Jindong Xie, Xinpei Deng, Qi Wang, Jianying Xu, Wenjie Shi, Chang Qi, Chunrun Qu, Xufeng Huang, András Hajdu, Chaoqun Li, Changmin Peng, Xuanye Cao, Guangsheng Pei, Lin Zhang, Yujia Huo, Jiabao Xu, Antonino Glaviano, Attila Gábor Szöllősi, Sicheng Bian, Zhengrui Li, Hailin Tang, Bufu Tang, Zaoqu Liu, Jian Zhang, Kai Miao, Quan Cheng, Ting Wei, Shuofeng Yuan, Peng Luo   +50 more
wiley   +1 more source