Results 61 to 70 of about 28,006 (231)

Pharmacokinetics of dolutegravir, tenofovir and lamivudine during venous–venous extracorporeal membrane oxygenation (VV‐ECMO): A case report

British Journal of Clinical Pharmacology, EarlyView.
While providing potentially life‐saving cardiorespiratory support for critically ill patients, extracorporeal membrane oxygenation (ECMO) may detrimentally affect pharmacokinetic (PK) performance and concurrent drug efficacy and safety. We describe a patient with Pneumocystis jirovecii pneumonia (PJP) in the context of acquired immunodeficiency ...
Tom C. Zwart, Emiel Leegwater, Thomas H. Ottens, Emile F. Schippers, Erik B. Wilms, David M. Burger, Cees van Nieuwkoop, Liesbeth B. E. Bosma   +7 more
wiley   +1 more source

Non‐Syndromic Tumefactive Demyelinating Lesions in the Pediatric Population: Four Case Reports and Review of the Literature

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Introduction Tumefactive demyelinating lesions (TDLs) are large lesions (> 2 cm) seen in demyelinating syndromes such as multiple sclerosis, myelin oligodendrocyte glycoprotein antibody‐associated disorder, and neuromyelitis optica spectrum disorder. They rarely occur in children and most often have a monophasic course.
Elizabeth C. Ballinger, Hannah F. Todd, Jonathan M. Yarimi, Timothy E. Lotze, Nikita M. Shukla, Kristen S. Fisher, Alexander J. Sandweiss   +6 more
wiley   +1 more source

Aseptic Meningitis Epidemic during a West Nile Virus Avian Epizootic

Emerging Infectious Diseases, 2003
While enteroviruses have been the most commonly identified cause of aseptic meningitis in the United States, the role of the emerging, neurotropic West Nile virus (WNV) is not clear.
Kathleen G. Julian, James A. Mullins, Annette Olin, Heather Peters, W. Allan Nix, M. Steven Oberste, Judith C. Lovchik, Amy Bergmann, Ross J. Brechner, Robert A. Myers, Anthony A. Marfin, Grant L. Campbell   +11 more
doaj   +1 more source

A novel druggable interprotomer pocket in the capsid of rhino- and enteroviruses

PLoS Biology, 2019
Rhino- and enteroviruses are important human pathogens, against which no antivirals are available. The best-studied inhibitors are “capsid binders” that fit in a hydrophobic pocket of the viral capsid.
R. Abdelnabi, James A. Geraets, Yipeng Ma, C. Mirabelli, J. Flatt, Aušra Domanska, Leen Delang, D. Jochmans, T. A. Kumar, Venkatesan Jayaprakash, B. N. Sinha, P. Leyssen, S. Butcher, J. Neyts   +13 more
semanticscholar   +1 more source

Aggregation‐induced emission luminogens in in vitro diagnostics: Advancing biomarker detection in body fluids

Interdisciplinary Medicine, EarlyView.
This review systematically summarizes recent advances in aggregation‐induced emission (AIE) materials for in vitro diagnostics (IVD). It highlights probe design strategies—categorizing them into direct‐responsive, indirect‐responsive, and nano‐immunoprobes—and their applications in detecting a wide range of biomarkers across diverse body fluids ...
Qi Liu, Xirui Chen, Kenian Wang, Yifan Wu, Xiangcai Zou, Ying Li   +5 more
wiley   +1 more source

Monitoring the VDPV2 outbreak in Egypt during 2020–2021 highlights the crucial role of environmental surveillance and boosting immunization in combating Poliovirus

BMC Infectious Diseases
Background Poliovirus is a highly infectious enterovirus (EV) that primarily affects children and can lead to lifelong paralysis or even death. Vaccine-derived polioviruses (VDPVs) are a great threat since they are derived from the attenuated virus in ...
Menna R. Shabana, Amira Y. Zaghloul, Tamer H. El Shaarawy, Nooran S. Elleboudy, Khaled M. Aboshanab   +4 more
doaj   +1 more source

A case of autoimmune hepatitis in a patient with inflammatory bowel disease and significant lymphadenopathy in the porta hepatis

JPGN Reports, EarlyView.
Abstract The diagnosis of autoimmune hepatitis (AIH) is supported by the presence of elevated transaminases, hypergammaglobulinemia, liver biopsy consistent with AIH, and the presence of AIH autoantibodies. In this case presentation, we highlight the challenges associated with diagnosing AIH in a patient with inflammatory bowel disease (IBD) who ...
Benjamin J. Malamet, Shannon Joerger, Karen Caudill, Mai He, Juan Reyes Genere, Janis Stoll   +5 more
wiley   +1 more source

Enterovirus Replication Organelles and Inhibitors of Their Formation

Frontiers in Microbiology, 2020
Enteroviral replication reorganizes the cellular membrane. Upon infection, viral proteins and hijacked host factors generate unique structures called replication organelles (ROs) to replicate their viral genomes.
Xinhong Li, Xinhong Li, Xinhong Li, Mingshu Wang, Mingshu Wang, Mingshu Wang, Anchun Cheng, Anchun Cheng, Anchun Cheng, Xingjian Wen, Xingjian Wen, Xingjian Wen, Xumin Ou, Xumin Ou, Xumin Ou, Sai Mao, Sai Mao, Sai Mao, Qun Gao, Qun Gao, Qun Gao, Di Sun, Di Sun, Di Sun, Renyong Jia, Renyong Jia, Renyong Jia, Qiao Yang, Qiao Yang, Qiao Yang, Ying Wu, Ying Wu, Ying Wu, Dekang Zhu, Dekang Zhu, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Shun Chen, Shun Chen, Shun Chen, Mafeng Liu, Mafeng Liu, Mafeng Liu, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Yunya Liu, Yunya Liu, Yunya Liu, Yanling Yu, Yanling Yu, Yanling Yu, Ling Zhang, Ling Zhang, Ling Zhang, Bin Tian, Bin Tian, Leichang Pan, Leichang Pan, Xiaoyue Chen, Xiaoyue Chen, Xiaoyue Chen   +62 more
doaj   +1 more source

Efficacy of inactivation of human enteroviruses by dual-wavelength germicidal ultraviolet (UV-C) light emitting diodes (LEDs).

Water, 2019
The efficacy of germicidal ultraviolet (UV-C) light emitting diodes (LEDs) was evaluated for inactivating human enteroviruses included on the United States Environmental Protection Agency (EPA)'s Contaminant Candidate List (CCL).
Hyoungmin Woo, Sara E. Beck, L. Boczek, K. M. Carlson, Nichole E. Brinkman, K. Linden, O. Lawal, S. Hayes, H. Ryu   +8 more
semanticscholar   +1 more source

Novel Wide‐Spectrum Virucidal Lipid Nanoparticles

Small, EarlyView.
POSTAN is a novel broad‐spectrum antiviral nanoparticle that combines safety with potent virucidal activity. Composed of biocompatible lipids, it mimics heparan sulfate proteoglycans and lipid rafts exploited by viruses, thereby dismantling viral envelopes and blocking replication.
Yugo Araújo Martins, Louise Bondeelle, Arnaud Charles‐Antoine Zwygart, Thais Melquiades de Lima, Juliano de Paula Souza, Han Kang Tee, Fernando Chahud, Eurico de Arruda Neto, Francesco Stellacci, Renata Fonseca Vianna Lopez, Caroline Tapparel   +10 more
wiley   +1 more source