Results 71 to 80 of about 1,391 (151)

Mechanical Signaling: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 6, Issue 12, December 2025.
In this review, we summarize cell–ECM interactions and delve into the complex mechanotransduction. We introduce advanced research methods and emerging clinical tools used to study cellular mechanical phenotypes, mechanotransduction, and disease progression. Additionally, we analyze the role of mechanical biomarkers in the development and progression of
Yicen Long, Peng Wang, Jiacheng Lei, Baihai Su, Qiang Wei, Xiaojing Liu   +5 more
wiley   +1 more source

Mitosis can drive cell cannibalism through entosis

, 2020
Entosis is a form of epithelial cell cannibalism that is prevalent in human cancer, typically triggered by loss of matrix adhesion. Here, we report an alternative mechanism for entosis in human epithelial cells, driven by mitosis.
Lucy Collinson (3507032), Joanne Durgan (8128935), Michael Overholtzer (660883), Oliver Florey (660881), Jens C Hamann (8128932), Alan Hall (245041), Marie-Charlotte Domart (116370), Yun-Yu Tseng (2315923)   +7 more
core  

Hepatocytes Delete Regulatory T Cells by Enclysis, a CD4+ T Cell Engulfment Process

Cell Reports, 2019
Summary: CD4+ T cells play critical roles in directing immunity, both as T helper and as regulatory T (Treg) cells. Here, we demonstrate that hepatocytes can modulate T cell populations through engulfment of live CD4+ lymphocytes. We term this phenomenon
Scott P. Davies, Gary M. Reynolds, Alex L. Wilkinson, Xiaoyan Li, Rebecca Rose, Maanav Leekha, Yuxin S. Liu, Ratnam Gandhi, Emma Buckroyd, Joe Grove, Nicholas M. Barnes, Robin C. May, Stefan G. Hubscher, David H. Adams, Yuehua Huang, Omar Qureshi, Zania Stamataki   +16 more
doaj   +1 more source

Regulated cell death (RCD) in cancer: key pathways and targeted therapies

Signal Transduction and Targeted Therapy, 2022
Regulated cell death (RCD), also well-known as programmed cell death (PCD), refers to the form of cell death that can be regulated by a variety of biomacromolecules, which is distinctive from accidental cell death (ACD).
Fu Peng, Minru Liao, Rui Qin, Shiou Zhu, Cheng Peng, Leilei Fu, Yi Chen, Bo Han   +7 more
doaj   +1 more source

Exploring the Neuroprotective Role of Selenium: Implications and Perspectives for Central Nervous System Disorders

Exploration, Volume 5, Issue 4, August 2025.
Selenium (Se) is a crucial element in selenoproteins, key biomolecules for physiological function in vivo. Central nervous system can express all 25 kinds of selenoproteins, which protect neurons by reducing oxidative stress and inflammatory response. Neuroprotection is being investigated through the biological study of Se.
Guanning Huang, Ying Liu, Xiadong Zhu, Lizhen He, Tianfeng Chen   +4 more
wiley   +1 more source

Oxidative Stress Resistance in Metastatic Prostate Cancer: Renewal by Self-Eating.

PLoS ONE, 2015
Resistant cancer phenotype is a key obstacle in the successful therapy of prostate cancer. The primary aim of our study was to explore resistance mechanisms in the advanced type of prostate cancer cells (PC-3) and to clarify the role of autophagy in ...
Jan Balvan, Jaromir Gumulec, Martina Raudenska, Aneta Krizova, Petr Stepka, Petr Babula, Rene Kizek, Vojtech Adam, Michal Masarik   +8 more
doaj   +1 more source

The Life of a Kidney Podocyte

Acta Physiologica, Volume 241, Issue 8, August 2025.
ABSTRACT Aim Podocytes, highly specialized epithelial cells located in the glomerulus of the kidney, are essential to the filtration barrier that ensures separation of blood and urine. These cells exhibit a unique architecture, characterized by an intricate network of foot processes interconnected by slit diaphragms, which serve as a critical selective
Desiree Loreth, Wiebke Sachs, Catherine Meyer‐Schwesinger   +2 more
wiley   +1 more source

High-LET Proton Irradiation Significantly Alters the Clonogenic and Tumorigenic Potential of Human Breast Cancer Cell Lines In Vitro and In Vivo

Frontiers in Bioscience-Landmark
Background: The implementation of proton beam irradiation (PBI) for breast cancer (BC) treatment is rapidly advancing due to its enhanced target coverage and reduced toxicities to organs at risk.
Margarita Pustovalova, Rita Mohammad, Yuzhe Wang, Wenyu Xue, Philipp Malakhov, Viktor Nekrasov, Elizaveta Kontareva, Zain Nofal, Vyacheslav Saburov, Dmitry Kolesov, Andreyan Osipov, Sergey Leonov   +11 more
doaj   +1 more source

Integrating Multi‐Omics Data Using Machine Learning to Explore New Therapeutic Targets for Acute Kidney Injury

Journal of Cellular and Molecular Medicine, Volume 29, Issue 16, August 2025.
ABSTRACT Renal ischemia–reperfusion (I/R) injury is an unavoidable complication associated with renal transplantation, and currently, there are no targeted therapeutic interventions. The objective of this study was to explore the molecular mechanisms that contribute to I/R‐induced acute kidney injury (I/R‐AKI) and to discover potential targets for ...
Qiming Gong, Yakun Wang, Fahui Liu, Tingting Zhou, Mengqin Tu, Junle Li, Wei Huang, Xu Lin, Wenjuan Sun   +8 more
wiley   +1 more source

Nanomedicine Approaches for Autophagy Modulation in Cancer Therapy

Small Science, Volume 5, Issue 6, June 2025.
Autophagy modulation holds promise for enhancing cancer treatment, yet clinical translation remains challenging. This review explores nanomedicine‐based strategies to improve autophagy‐targeting drugs, highlighting their synergy with chemotherapy, immunotherapy, phototherapy, and gene therapy. It also discusses nanoparticle design and clinical progress,
Sohaib Mahri, Rodolfo Villa, Ya‐Ping Shiau, Menghuan Tang, Kelsey Jane Racacho, Qiufang Zong, Saiful Islam Chowdhury, Tan Hua, Felipe Godinez, Andrew Birkeland, Tzu‐Yin Lin, Yuanpei Li   +11 more
wiley   +1 more source