Results 61 to 70 of about 1,391 (151)

Preliminary evidence for the presence of multiple forms of cell death in diabetes cardiomyopathy

Acta Pharmaceutica Sinica B, 2022
Diabetic mellitus (DM) is a common degenerative chronic metabolic disease often accompanied by severe cardiovascular complications (DCCs) as major causes of death in diabetic patients with diabetic cardiomyopathy (DCM) as the most common DCC.
Jinjing Wei, Yongting Zhao, Haihai Liang, Weijie Du, Lihong Wang   +4 more
doaj   +1 more source

Single‐Cell Transcriptomic Analysis of Chemotherapy‐Induced Changes in Osteosarcoma With a Pyroptosis‐Related Gene‐Based Prognostic Model

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Osteosarcoma, the most common primary malignant bone tumour, presents significant treatment challenges due to its complex tumour microenvironment and the development of chemoresistance. This study employs single‐cell transcriptomics to investigate chemotherapy‐induced changes in osteosarcoma at both the cellular and molecular levels.
Tao Jin, Lei Dong, Wang Kai, Ziyang Yu, Guoyong Yu, Weifeng Liu   +5 more
wiley   +1 more source

Mesenchymal stem cells generate distinc functional hybrids via cell fusion or entosis [PDF]

, 2017
Homotypic and heterotypic cell-cell fusion are key processes during development and tissue regeneration. On the other hand, aberrant heterotypic cell fusion between cancer and normal cells can contribute to tumor initiation and metastasis.
Sottile, Francesco, Sottile, Francesco, 1988-   +1 more
core   +1 more source

ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling

Advanced Science, Volume 13, Issue 16, 18 March 2026.
ERM inhibition disrupts ERM‐actin interactions, elevating ROS and triggering KEAP1 degradation, which stabilizes and activates NRF2. Nuclear NRF2 induces cytoprotective genes, notably HMOX1, enhancing redox buffering and suppressing lipid peroxidation to resist erastin‐induced ferroptosis.
Menghao Qiao, Liqun Zhou, Minhua Zhou, Yu Fang, Haiying Mai, Lingbo Cao, Kun Xu, Yuan Sang, Minyi Chen, Jiewei Huang, Peiyi Huang, Zhipeng Yan, Chao Wang, Zhangshuai Dai, Dichun Huang, Ronghan He, Lijuan Pang, Yunmiao Guo, Ting Gang Chew, Junqi Huang   +19 more
wiley   +1 more source

Entosis in Colorectal, Lung, and Breast Cancer: Associations with Clinicopathological Features, Patient Outcomes, and Copy Number Alteration Landscape

Journal of Molecular Pathology
Objective: This study examined the frequency of entosis in solid tumors of various origins (colorectal cancer, breast cancer, and lung cancer) and its association with clinical and pathological characteristics.
Ksenia A. Gaptulbarova, Sergey V. Vtorushin, Marina K. Ibragimova, Irina A. Tsydenova, Natalia A. Tarabanovskaya, Vitaly P. Shubin, Aleksey S. Tsukanov, Evgeny O. Rodionov, Sergey I. Achkasov, Nikolai V. Litviakov   +9 more
doaj   +1 more source

Label‐free imaging of intracellular structures in living mammalian cells via external apodization phase‐contrast microscopy

The FEBS Journal, Volume 293, Issue 4, Page 1127-1149, February 2026.
Advanced techniques to visualize the spatiotemporal functionality of biomolecules are essential for elucidating mechanisms governing cellular behavior. External apodization phase‐contrast (ExAPC) microscopy enables label‐free visualization of diverse intracellular structures in living mammalian cells. By enhancing phase‐contrast imaging through optical
Hiroshi Ohno, Takenori Nishimura, Kenta Kainoh, Yoshitaka Ohashi, Naoko Onodera, Mayuko Kano, Lay Nurhana Sari, Masato Masuda, Yoshiaki Tamura, Teppei Nishino, Yusuke Hayashi, Yusuke Yamamoto, Shin‐Ichiro Takahashi, Yuta Mishima, Yosuke Yoneyama, Yoshinori Takeuchi, Motohiro Sekiya, Takashi Matsuzaka, Takafumi Miyamoto, Hitoshi Shimano   +19 more
wiley   +1 more source

Advancing Prognosis Prediction and Immunotherapy Efficacy in Lung Adenocarcinoma Through Machine Learning: Novel Insights From Anoikis Regulator Patterns in Single‐Cell Multiomics

International Journal of Genomics, Volume 2026, Issue 1, 2026.
Introduction Anoikis, a type of programmed cell death induced by detachment from the extracellular matrix (ECM), is crucial in cancer progression. Resistance to anoikis often correlates with enhanced invasion, metastasis, treatment resistance, and tumor recurrence.
Shan Li, Wenhang Zhou, Chen Hu, Ting Chen, Jinping Li, Pengpeng Zhang   +5 more
wiley   +1 more source

Cell Death and Liver Disease

Gut and Liver, 2020
Cell death is now reclassified into several types based on the mechanisms and morphologic phenotype. Understanding of such classifications offers insights into the pathogenesis of liver disease, as well as diagnostic or therapeutic implications ...
Satoka Aizawa, Gurmehr Brar, Hidekazu Tsukamoto   +2 more
doaj   +1 more source

Navigating Transition Metal‐Dependent Cell Death: Mechanisms, Crosstalk, and Future Directions

Advanced Science, Volume 12, Issue 46, December 11, 2025.
Transition metals trigger distinct regulated cell death pathways beyond traditional apoptosis. This review examines ferroptosis (iron‐catalyzed lipid peroxidation) and cuproptosis (copper‐induced mitochondrial proteotoxicity), while exploring hypothetical “cobaltosis” as a novel pathway.
Qinghang Song, Yuxuan Yang, Lina Yang
wiley   +1 more source

Deciphering the Molecular Mechanisms of Orai1-dependent Entosis in Cancer Development and SEPTINs Cleavage-mediated Ciliary Defects in Coronavirus Infection [PDF]

, 2023
Department of Biological SciencesThe cytoskeleton is a complex network of protein filaments that plays a crucial role in maintaining cell shape, organizing cellular components, and coordinating various cellular processes.
Lee, Ah Reum
core