Results 11 to 20 of about 4,881,376 (355)

Naringenin derivatives as glucosamine-6-phosphate synthase inhibitors: synthesis, antioxidants, antimicrobial, preservative efficacy, molecular docking and in silico ADMET analysis

BMC Chemistry, 2020
Background Preservatives have to be added in food, pharmaceuticals and cosmetics products to maintain their shelf life. However, the existing chemical based preservatives have been associated with severe side effects that compel the researchers to find ...
Amit Lather, Sunil Sharma, Anurag Khatkar   +2 more
doaj   +1 more source

Lead optimization for promising monoamine oxidase inhibitor from eugenol for the treatment of neurological disorder: synthesis and in silico based study

BMC Chemistry, 2019
Natural based inhibitors of monoamine oxidase are promising drug candidates for the treatment of several neurodegenerative and neuropsychological disorders including depression, anxiety, Parkinson’s disease and Alzheimer’s disease.
Priyanka Dhiman, Neelam Malik, Anurag Khatkar   +2 more
doaj   +1 more source

Natural based piperine derivatives as potent monoamine oxidase inhibitors: an in silico ADMET analysis and molecular docking studies

BMC Chemistry, 2020
Neurodegenerative disorders follow numerous pathological ways concerning overexpression of monoamine oxidase and formation of reactive oxygen species.
Priyanka Dhiman, Neelam Malik, Anurag Khatkar   +2 more
doaj   +1 more source

Advances in Deubiquitinating Enzyme Inhibition and Applications in Cancer Therapeutics

Cancers, 2020
Since the discovery of the ubiquitin proteasome system (UPS), the roles of ubiquitinating and deubiquitinating enzymes (DUBs) have been widely elucidated.
Ainsley Mike Antao, Apoorvi Tyagi, Kye-Seong Kim, S. Ramakrishna   +3 more
semanticscholar   +1 more source

Hybrid caffeic acid derivatives as monoamine oxidases inhibitors: synthesis, radical scavenging activity, molecular docking studies and in silico ADMET analysis

Chemistry Central Journal, 2018
Background Monoamine oxidase has been implicated in numerous neurological disorders. Although synthetic monoamine oxidase inhibitors (MAOI) have emerged with many side effects, the aspiration of natural based MAOI has greatly increased.
Priyanka Dhiman, Neelam Malik, Anurag Khatkar   +2 more
doaj   +1 more source

Amygdalin based G-6-P synthase inhibitors as novel preservatives for food and pharmaceutical products

Scientific Reports, 2020
G-6-P synthase enzyme has been involved in the synthesis of the microbial cell wall, and its inhibition may lead to the antimicrobial effect. In the present study, we designed a library of amygdalin derivatives, and two most active derivatives selected ...
Amit Lather, Sunil Sharma, Anurag Khatkar   +2 more
doaj   +1 more source

In-silico design, synthesis, ADMET studies and biological evaluation of novel derivatives of Chlorogenic acid against Urease protein and H. Pylori bacterium

BMC Chemistry, 2019
Background Plants have always played important role in treating human and animal diseases as a therapeutic agent for traditional medicine. Through extensive research throughout the world, potential of natural products have been identified to control the ...
Ritu Kataria, Anurag Khatkar
doaj   +1 more source

Molecular docking, synthesis, kinetics study, structure–activity relationship and ADMET analysis of morin analogous as Helicobacter pylori urease inhibitors

BMC Chemistry, 2019
Background Urease are responsible for several pathogenic states in human as well as in animals and its inhibition is utmost urgent. Clinically used drugs are associated with many side effects; recently several researches have shown that flavonoids have ...
Ritu Kataria, Anurag Khatkar
doaj   +1 more source

In silico design and synthesis of hesperitin derivatives as new xanthine oxidase inhibitors

BMC Chemistry, 2019
Background Hesperitin, a naturally occurring flavonoid was hybridized with phenolic acids to evaluate its potential to inhibit the activity of xanthine oxidase (XO), a key enzyme which catalyses xanthine to uric acid which is found to be associated with ...
Neelam Malik, Priyanka Dhiman, Anurag Khatkar   +2 more
doaj   +1 more source

Kinetics and computational study of butyrylcholinesterase inhibition by methylrosmarinate: relevance to Alzheimer’s disease treatment

Heliyon, 2022
Butyrylcholinesterase (BChE) performs a significant function in Alzheimer’s disease progression. Experimental studies have shown that the function of BChE in the attenuation of cholinergic neurotransmission is essentially altered in brains of advanced AD
Sani Muhammad Uzairu, Yahaya Tijani, Madu Adamu Gadaka, Babagana Modu, Miriam Watafua, Hadiza Ali Ahmad, Umar Abdullahi Zakariya, Aminu Ibrahim, Aliyu Daja, Hassan Zanna, Abdullahi Balarabe Sallau   +10 more
doaj   +1 more source