Results 11 to 20 of about 4,886,955 (347)

Recent Advances in Electrochemical Biosensors Based on Enzyme Inhibition for Clinical and Pharmaceutical Applications

Sensors, 2018
A large number of enzyme inhibitors are used as drugs to treat several diseases such as gout, diabetes, AIDS, depression, Parkinson’s and Alzheimer’s diseases. Electrochemical biosensors based on enzyme inhibition are useful devices for an easy, fast and
Loubna El Harrad, Ilhame Bourais, Hasna Mohammadi, Aziz Amine   +3 more
doaj   +2 more sources

Biosensors Based on Enzyme Inhibition [PDF]

Advances in Biochemical Engineering/Biotechnology, 2013
The present chapter describes the use of biosensors based on enzyme inhibition as analytical tools. The parameters that affect biosensor sensitivity, such as the amount of immobilized enzyme, incubation time, and immobilization type, were critically evaluated, highlighting how the knowledge of enzymatic kinetics can help researchers optimize the ...
ARDUINI, FABIANA, Amine, A.
openaire   +4 more sources

Enzyme Inhibition [PDF]

Catalysis from A to Z, 2020
P. Sears
openaire   +2 more sources

Mixed and non-competitive enzyme inhibition: underlying mechanisms and mechanistic irrelevance of the formal two-site model

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
The formal mechanism of linear mixed and non-competitive enzyme inhibition implies the binding of inhibitors to both the active site of the free enzyme in competition with the substrate, and to an allosteric site on the enzyme-substrate complex. However,
A. Pesaresi
semanticscholar   +1 more source

Electrochemical Biosensors Based on Enzyme Inhibition Effect

The chemical record, 2023
Several electrochemical biosensors based on various enzyme inhibition effects have been designed; their laboratory prototypes have been manufactured and thoroughly investigated.
V. Arkhypova, O. Soldatkin, A. Soldatkin, S. Dzyadevych   +3 more
semanticscholar   +1 more source

Indole Chloropyridinyl Ester-Derived SARS-CoV-2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure–Activity Relationship, and X-ray Structural Studies

Journal of Medicinal Chemistry, 2021
Here, we report the synthesis, structure–activity relationship studies, enzyme inhibition, antiviral activity, and X-ray crystallographic studies of 5-chloropyridinyl indole carboxylate derivatives as a potent class of SARS-CoV-2 chymotrypsin-like ...
Arun K. Ghosh, Jakka Raghavaiah, D. Shahabi, M. Yadav, B. Anson, E. Lendy, S. Hattori, Nobuyo Higashi-Kuwata, H. Mitsuya, A. Mesecar   +9 more
semanticscholar   +1 more source

Advances in Deubiquitinating Enzyme Inhibition and Applications in Cancer Therapeutics

Cancers, 2020
Since the discovery of the ubiquitin proteasome system (UPS), the roles of ubiquitinating and deubiquitinating enzymes (DUBs) have been widely elucidated.
Ainsley Mike Antao, Apoorvi Tyagi, Kye-Seong Kim, S. Ramakrishna   +3 more
semanticscholar   +1 more source

Hybrid caffeic acid derivatives as monoamine oxidases inhibitors: synthesis, radical scavenging activity, molecular docking studies and in silico ADMET analysis

Chemistry Central Journal, 2018
Background Monoamine oxidase has been implicated in numerous neurological disorders. Although synthetic monoamine oxidase inhibitors (MAOI) have emerged with many side effects, the aspiration of natural based MAOI has greatly increased.
Priyanka Dhiman, Neelam Malik, Anurag Khatkar   +2 more
doaj   +1 more source

Phage display-derived inhibitor of the essential cell wall biosynthesis enzyme MurF [PDF]

, 2008
Background To develop antibacterial agents having novel modes of action against bacterial cell wall biosynthesis, we targeted the essential MurF enzyme of the antibiotic resistant pathogen Pseudomonas aeruginosa.
Blewett, Ann, Bugg, Tim, Clark, Tom, Levesque, Roger C., Lloyd, Adrian, Paradis-Bleau , Catherine, Sanschagrin, François   +6 more
core   +4 more sources

Amygdalin based G-6-P synthase inhibitors as novel preservatives for food and pharmaceutical products

Scientific Reports, 2020
G-6-P synthase enzyme has been involved in the synthesis of the microbial cell wall, and its inhibition may lead to the antimicrobial effect. In the present study, we designed a library of amygdalin derivatives, and two most active derivatives selected ...
Amit Lather, Sunil Sharma, Anurag Khatkar   +2 more
doaj   +1 more source