Results 71 to 80 of about 1,681,787 (293)

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Enzyme kinetics for a two-step enzymic reaction with comparable initial enzyme-substrate ratios [PDF]

, 1988
We extend the validity of the quasi-steady state assumption for a model double intermediate enzyme-substrate reaction to include the case where the ratio of initial enzyme to substrate concentration is not necessarily small.
P. K. Maini, Maini, P. K., Frenzen, C. L., Frenzen, CL, Maini, Philip, Maini, PK, C. L. Frenzen   +6 more
core   +1 more source

An information theory approach to quantifying the sequence-dependent response of nucleic acid motors with applications to nanopore DNA sequencing

Nature Communications
Motor enzymes that interact with DNA are essential for replicative biological processes. In nanopore sequencing, a motor enzyme controls the motion of a nucleic acid through a protein nanopore, and sequence-dependent blockages of an ion current flowing ...
Jonathan M. Craig, Andrew H. Laszlo, Henry Brinkerhoff, Christopher A. Thomas, Sinduja K. Marx, Eric F. Lebo, Sarah J. Abell, Michaela C. Franzi, Jesse R. Huang, Hwanhee C. Kim, Jessica D. Carrasco, Jens H. Gundlach   +11 more
doaj   +1 more source

Adsorption of peroxidase from L onto alginate–guar gum matrix: Kinetic, equilibrium and thermodynamic analysis

Adsorption Science & Technology, 2016
This work explores the kinetics, equilibrium and thermodynamics of peroxidase adsorption onto spherical guar gum–alginate matrices. The effect of contact time, solution pH, initial protein concentration and temperature was studied in batch experiments ...
Ana C Santos Leite da Silva, Nadia Woitovich Valetti, María E Brassesco, José A Teixeira, Guillermo Picó   +4 more
doaj   +1 more source

Numerical Solution for Fuzzy Enzyme Kinetic Equations by the Runge–Kutta Method

Mathematical and Computational Applications, 2018
One of the most important biochemical reactions is catalyzed by enzymes. A numerical method to solve nonlinear equations of enzyme kinetics, known as the Michaelis and Menten equations, together with fuzzy initial values is introduced.
Yousef Barazandeh, Bahman Ghazanfari
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Kinetic modelling of the role of the aldehyde dehydrogenase enzyme and the breast cancer resistance protein in drug resistance and transport [PDF]

, 2011
A compartmental model for the in vitro uptake kinetics of the anti-cancer agent topotecan (TPT) has been extended from a previously published model. The extended model describes the drug activity and delivery of the pharmacologically active form to the ...
N.D. Evans, Evans, Neil D., M.J. Chappell, Errington, Rachel J., R.J. Errington, Smith, Paul J., Smith, Paul James, Atari, M. I., Chappell, M. J., P.J. Smith, Chappell, M. J. (Michael J.), M.I. Atari, Errington, Rachel Jane, Evans, N. D.   +13 more
core   +1 more source

On Over-Parameterisation and Parameter Estimation of Enzyme Kinetics

AppliedChem
The estimation of kinetic parameters based on experiments is an important element in understanding the reaction mechanisms of enzymes and their intrinsic properties.
Thomas Waluga, Paras Nagshi
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source