Results 61 to 70 of about 1,681,787 (293)

Principal basis for enzyme power [PDF]

, 2008
The reaction rate enhancement that enzymes produce had not been fully appreciated. The object of the article is to present the mechanism of the enormous catalytic power of the enzymes.
Alexander G. Foigel
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Enzyme activity and dynamics in near-anhydrous conditions [PDF]

, 2009
Water is widely assumed to be essential for life 1, although the exact molecular basis of this requirement is unclear 2-4. Water facilitates protein motions 5-9 and although enzyme activity has been demonstrated at low hydrations in organic solvents 10 ...
John Finney, Moeava Tehei, Vandana Kurkal-Siebert, Jeremy Smith, Murielle Lopez, Rachel Dunn, Roy Daniel   +6 more
core  

Deconjugation Kinetics of Glucuronidated Phase II Flavonoid Metabolites by B-glucuronidase from Neutrophils [PDF]

, 2010
Flavonoids are inactivated by phase II metabolism and occur in the body as glucuronides. Mammalian ß-glucuronidase released from neutrophils at inflammatory sites may be able to deconjugate and thus activate flavonoid glucuronides.
Arts, I.C.W., Pieter C. Dagnelie, Needs, P.W., Paul A. Kroon, Jaap Keijer, Paul W. Needs, Keijer, J., Kroon, P.A., Roger Bartholomé, Hollman, P.C.H., Dirk Roos, Ilja C.W. Arts, Haenen, G., Peter C.H. Hollman, Dagnelie, P.C., Guido Haenen, Roos, D., Bartholomé, R., Bast, A., Aalt Bast   +19 more
core   +2 more sources

Kinetics of Enzyme Biodegradation of New Synthesized Copolymers [PDF]

Bioautomation, 2005
Block copolymers of the poly-(hexanlactam)-co-block-poly-(?-valerolactone) from ABA-type were synthesized via anionic polymerization of hexanlactam (HL) with the sodium salt of hexanlactam (Na-HL) as an initiator and polymeric activator (PAC).
Rosa Mateva, Natalia Toncheva, Lubov Yotova   +2 more
doaj  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Choice of reactor to minimize enzyme requirement - 1. Mathematical model for one-substrate Michaelis-Menten type kinetics in continuous reactors

, 2022
S.627-632 : Abb.,Lit.In order to establish the theoretically ideal conditions necessary to minimize enzyme requirement for a given process, a computer simulation of the ideal stirred tank reactor (CSTR), the ideal plug flow reactor (PFR) and the ideal ...
Chmiel, H., Kulbe, K.-D., Howaldt, M.
core   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source