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The role of eosinophils in the pathogenesis of asthma
Trends in Molecular Medicine, 2005Two recent papers have addressed the ever-intriguing question of the role of eosinophils in asthma. Both groups used experimental models of airway inflammation in mice that were gene targeted to selectively ablate the eosinophil lineage. One group found that eosinophils were required for both airway hyperresponsiveness and mucus accumulation. The other
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Mepolizumab for severe eosinophilic asthma
Expert Review of Respiratory Medicine, 2013In this large (616 patients), double-blind, placebo-controlled, dose-ranging study of mepolizumab (a monoclonal antibody that blocks IL-5 binding to its receptor), patients were given placebo, 75-, 250- or 750-mg mepolizumab by intravenous infusion every 4 weeks for 1 year.
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Antagonism of Eosinophil Accumulation in Asthma
Recent Patents on Inflammation & Allergy Drug Discovery, 2010There is considerable evidence that implicates eosinophils as important effector cells and immunomodulators in the inflammation characteristic of asthma. Numerous in vitro and animal studies have demonstrated essential roles for cell adhesion molecules in eosinophil adhesion and transendothelial migration including the selectins, ICAM-1, VCAM-1 ...
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Mepolizumab for severe eosinophilic asthma
Expert Review of Respiratory MedicineSevere eosinophilic asthma is a distinct asthma phenotype that is characterized by elevated blood eosinophils, frequent exacerbations and dependence on treatment with systemic corticosteroids. The development of Mepolizumab, a monoclonal antibody that targets Interleukin 5, has significantly transformed the therapeutic approach of patients with severe ...
Maria, Kallieri +2 more
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Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques, 1993
There has been continuing debate concerning the precise role of eosinophils. They appear to be an integral component in the pathogenesis of asthma, albeit their role has not as yet fully delineated.
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There has been continuing debate concerning the precise role of eosinophils. They appear to be an integral component in the pathogenesis of asthma, albeit their role has not as yet fully delineated.
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Comparative features of eosinophilic and non‐eosinophilic asthma
Clinical & Experimental Allergy, 2021Isabelle Xu +4 more
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Eosinophilic Asthma, Phenotypes-Endotypes and Current Biomarkers of Choice
Journal of Personalized Medicine, 2022Konstantinos Porpodis +2 more
exaly