Results 61 to 70 of about 51,600 (308)

Boron Nitride Nanomaterials Trigger Immunomodulatory Effects in Human Broncho‐Epithelial Cells by Modulating Eicosanoid Lipid Signaling

Advanced Science, EarlyView.
This study demonstrates that BNNT exposure disrupts lipid homeostasis in bronchial epithelial cell cultures and activates eicosanoid lipid biosynthesis, producing inflammatory lipid mediators like leukotrienes. These effects are more pronounced in asthmatic cell cultures compared to healthy ones.
Govind Gupta, Jonas Bossart, Sènan Mickael D'Almeida, Luis Augusto Visani de Luna, Christoph Schwärzler, Tingting Fu, Vanesa Ayala‐Nunez, Alexander Gogos, Marija Buljan, Vera M Kissling, Emmanuel Flahaut, Miguel Garcia, Cyrill Bussy, Peter Wick, Tina Buerki‐Thurnherr   +14 more
wiley   +1 more source

Eosinophilic otitis media a literature review [PDF]

, 2013
Eosinophilic otitis media is actually a recent introduction. These patients may manifest with sudden hearing loss. There may be associated bronchial asthma and allergic rhinitis. Diagnostic criteria of this condition are rather vague.
Thiagarajan, Balasubramanian
core   +1 more source

Bronchoscopy, Imaging, and Concurrent Diseases in Dogs with Bronchiectasis: (2003-2014). [PDF]

, 2015
BackgroundBronchiectasis is a permanent and debilitating sequel to chronic or severe airway injury, however, diseases associated with this condition are poorly defined.ObjectiveTo evaluate results of diagnostic tests used to document bronchiectasis and ...
Byrne, BA, Johnson, EG, Johnson, LR, Kass, PH, Vernau, W   +4 more
core   +1 more source

Eosinophilic bioactivities in severe asthma [PDF]

World Allergy Organization Journal, 2016
Asthma is clearly related to airway or blood eosinophilia, and asthmatics with significant eosinophilia are at higher risk for more severe disease. Eosinophils actively contribute to innate and adaptive immune responses and inflammatory cascades through the production and release of diverse chemokines, cytokines, lipid mediators and other growth ...
Carr, Tara F, Berdnikovs, Sergejs, Simon, Hans-Uwe, Bochner, Bruce S, Rosenwasser, Lanny J   +4 more
openaire   +4 more sources

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

Lonicerin attenuates house dust mite-induced eosinophilic asthma through targeting Src/EGFR signaling

Frontiers in Pharmacology, 2022
Eosinophilic asthma is the predominant phenotype of asthma, and although these patients are sensitive to glucocorticoid therapy, they also experience many side effects.
Zhenan Deng, Xuefei Zhang, Junjie Wen, Xiaojing Yang, Lingna Xue, Changxing Ou, Jianjuan Ma, Hongrui Zhan, Xiaomin Cen, Xuliang Cai, Yu Zhang, Riken Chen, Qingling Zhang   +12 more
doaj   +1 more source

Mepolizumab in refractory eosinophilic asthma [PDF]

Thorax, 2010
In a recent Lung Alert reviewing our study of mepolizumab in severe eosinophilic asthma,1 Barratt states that the study population represented a minority of patients with asthma and that they had corticosteroid-resistant disease.2 These comments require clarification.
Pavord, ID, Haldar, P, Bradding, P, Wardlaw, AJ   +3 more
openaire   +3 more sources

The Global Airways in Practice: Long‐term Effects of Mepolizumab With or Without FESS on Type 2 Inflammation in Patients With CRSwNP

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is a type 2 inflammatory disease often associated with asthma. The global airway hypothesis suggests bidirectional inflammatory interactions between upper and lower airways. Mepolizumab, an anti–IL‐5 therapy, treats conditions systemically, while functional endoscopic sinus surgery ...
Jens Tidemandsen, Vibeke Backer, Anne Sophie Homøe, Thomas H. L. Jensen, Kasper Aanæs, Howraman Meteran, Morten Hostrup, Lukas Moesgaard, Christiane Haase, Peter G. Gibson   +9 more
wiley   +1 more source

Development of Artificial Intelligence for Quantitative Assessment of Nasal Inflammatory Cytology in Chronic Rhinitis by Whole‐Slide Images

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinitis (CR) is currently recognized as a syndrome that manifests in different phenotypes. We aimed to establish an artificial intelligence system (quantitative assessment of nasal inflammatory cytology, QANIC) on the basis of whole‐slide images (WSIs) to enable quantitative assessment of nasal inflammatory cells.
Xu Zhang, Xu Xu, Weiwei Liu, Long Qin, Yu Song, Jingyun Li, Lin Xi, Chengshuo Wang, Luo Zhang, Yuan Zhang   +9 more
wiley   +1 more source

Management of Severe Asthma in Eosinophilic Granulomatosis with Polyangiitis with Interleukin-5-Targeted Therapies: Current Status and Report of Two Cases

Applied Sciences, 2022
Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic disorder characterized by peripheral eosinophilia, severe eosinophilic asthma, sinusitis, transient pulmonary infiltrates, and features of medium/small-vessel vasculitis.
Ciro Romano, Domenico Cozzolino, Ausilia Sellitto, Luca Rinaldi   +3 more
doaj   +1 more source