Results 11 to 20 of about 316,727 (384)
Eosinophils are important for protection, immunoregulation and pathology during infection with nematode microfilariae. [PDF]
PLoS Pathogens, 2014 Eosinophil responses typify both allergic and parasitic helminth disease. In helminthic disease, the role of eosinophils can be both protective in immune responses and destructive in pathological responses. To investigate whether eosinophils are involved
Emma T Cadman +6 more
doaj +4 more sources
Epigenetic and transcriptional programming of murine eosinophils in the esophagus [PDF]
Nature CommunicationsEosinophils accumulate in different tissues in allergies, cancer, and infectious diseases, adopting distinct properties. Herein, we profiled murine esophageal eosinophils during allergic inflammation using single-cell sequencing, epigenomic mapping, and ...
Jennifer M. Felton +19 more
doaj +2 more sources
Frontiers in Medicine, 2018 Bullous pemphigoid (BP) is an autoimmune blistering disease which carries a significant mortality and morbidity. While historically BP has been characterized as an IgG driven disease mediated by anti-BP180 and BP230 IgG autoantibodies, developments in ...
Kyle T. Amber +4 more
doaj +2 more sources
High fat diet causes depletion of intestinal eosinophils associated with intestinal permeability. [PDF]
PLoS ONE, 2015 The development of intestinal permeability and the penetration of microbial products are key factors associated with the onset of metabolic disease. However, the mechanisms underlying this remain unclear. Here we show that, unlike liver or adipose tissue,
Armando, Aaron M +6 more
core +12 more sources
Allergy. European Journal of Allergy and Clinical Immunology, 2023 Eosinophils are bone marrow‐derived granulocytes and are found in low numbers in the peripheral blood of healthy subjects. In type 2 inflammatory diseases, eosinopoiesis in the bone marrow is increased, resulting in a rise in the number of mature ...
Lea Gigon +4 more
semanticscholar +1 more source
Allergology International, 2021 Eosinophils not only play a critical role in the pathogenesis of eosinophil-associated diseases, but they also have multiple important biological functions, including the maintenance of homeostasis, host defense against infections, immune regulation ...
Akira Kanda +10 more
doaj +1 more source
Active eosinophils regulate host defence and immune responses in colitis
Nature, 2022 Single-cell transcriptomic profiling and functional assays are used to identify subpopulations of eosinophils that are present in the mouse gastrointestinal tract and provide insight into the role of these cells in inflammatory bowel diseases in humans ...
Alessandra Gurtner +20 more
semanticscholar +1 more source
Frontiers in Immunology, 2021 Eosinophils are multifunctional, evolutionary conserved leukocytes that are involved in a plethora of responses ranging from regulation of tissue homeostasis to host defense and cancer.
Avishay Dolitzky +8 more
doaj +1 more source
Annual Review of Immunology, 2021 The enigmatic eosinophil has emerged as an exciting component of the immune system, involved in a plethora of homeostatic and inflammatory responses. Substantial progress has been achieved through experimental systems manipulating eosinophils in vivo ...
E. Jacobsen +8 more
semanticscholar +1 more source
A role for eosinophils in the intestinal immunity against infective Ascaris suum larvae [PDF]
, 2013 The aim of this study was to explore the mechanisms of resistance against invading Ascaris suum larvae in pigs. Pigs received a low dose of 100 A. suum eggs daily for 14 weeks.
Chiers, Koen +6 more
core +14 more sources