Results 71 to 80 of about 136,090 (244)

Single-cell RNA-sequencing of circulating eosinophils from asthma patients reveals an inflammatory signature

iScience
Summary: Asthma is the most common chronic lung disorder in the United States. While asthma is heterogeneous, blood eosinophils are central to the pathogenesis in most cases.
Kyndal Goss, Melanie L. Grant, Cherish Caldwell, Gail A. Dallalio, Susan T. Stephenson, Anne M. Fitzpatrick, Edwin M. Horwitz   +6 more
doaj   +1 more source

Metabolic Profiling of Human Eosinophils

Frontiers in Immunology, 2018
Immune cells face constant changes in their microenvironment, which requires rapid metabolic adaptation. In contrast to neutrophils, which are known to rely near exclusively on glycolysis, the metabolic profile of human eosinophils has not been ...
Linsey Porter, Nicole Toepfner, Kathleen R. Bashant, Jochen Guck, Margaret Ashcroft, Neda Farahi, Edwin R. Chilvers   +6 more
doaj   +1 more source

CCL11/CCR3-dependent eosinophilia alleviates malignant pleural effusions and improves prognosis

npj Precision Oncology
Malignant pleural effusion (MPE) is a common occurrence in advanced cancer and is often linked with a poor prognosis. Eosinophils were reported to involve in the development of MPE. However, the role of eosinophils in MPE remains unclear.
Min Zhang, Lixia Xia, Wenbei Peng, Guogang Xie, Fei Li, Chao Zhang, Madiha Zahra Syeda, Yue Hu, Fen Lan, Fugui Yan, Zhangchu Jin, Xufei Du, Yinling Han, Baihui Lv, Yuejue Wang, Miao Li, Xia Fei, Yun Zhao, Kaijun Chen, Yan Chen, Wen Li, Zhihua Chen, Qiong Zhou, Min Zhang, Songmin Ying, Huahao Shen   +25 more
doaj   +1 more source

Genetic Contribution to Asthma Informs Acute Chest Syndrome Pathophysiology and Risk Stratification

American Journal of Hematology, EarlyView.
ABSTRACT Acute chest syndrome (ACS) is a severe complication of sickle cell disease (SCD) occurring in ~50% of patients, some presenting frequent episodes. We lack tools to identify patients at high risk of ACS occurrence or frequent episodes. Epidemiological studies have found an association between asthma and ACS, but whether this link is causal is ...
Sara El Aouhel, Vanessa Bellegarde, Stennio Da Silva Faria, Tristan St‐Laurent, Estelle Lecluze, Anne‐Laure Pham Hung d’Alexandry d’Orengiani, Frédéric Galactéros, Pablo Bartolucci, Marc‐André Legault, Guillaume Lettre, Thomas Pincez   +10 more
wiley   +1 more source

Activated eosinophil plays a role in promoting fibrosis in endometriotic lesion

Scientific Reports
The fibrosis mechanism in endometriosis is not elucidated. We investigated the role of eosinophil in fibrosis of endometriosis. The endometriotic stromal cells (ESCs) and endometrial epithelial cells (EECs) were subjected to in vitro experiments.
Yosuke Ono, Kota Tanaka, Erina Sato, Masami Ito, Di Zhang, Masako Honda, Tatsuyuki Ogawa, Hikaru Tagaya, Tomohiko Fukuda, Youichi Shinozaki, Kazuyoshi Kato, Schuichi Koizumi, Osamu Yoshino   +12 more
doaj   +1 more source

Eosinophils promote epithelial to mesenchymal transition of bronchial epithelial cells.

PLoS ONE, 2013
Eosinophilic inflammation and remodeling of the airways including subepithelial fibrosis and myofibroblast hyperplasia are characteristic pathological findings of bronchial asthma.
Atsushi Yasukawa, Koa Hosoki, Masaaki Toda, Yasushi Miyake, Yuki Matsushima, Takahiro Matsumoto, Daniel Boveda-Ruiz, Paloma Gil-Bernabe, Mizuho Nagao, Mayumi Sugimoto, Yukiko Hiraguchi, Reiko Tokuda, Masahiro Naito, Takehiro Takagi, Corina N D'Alessandro-Gabazza, Shigeru Suga, Tetsu Kobayashi, Takao Fujisawa, Osamu Taguchi, Esteban C Gabazza   +19 more
doaj   +1 more source

Gastrointestinal Manifestations in Rubinstein‐Taybi Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Rubinstein–Taybi syndrome is a rare genetic condition associated with a wide range of physical, cognitive, and developmental impairments, yet its gastrointestinal manifestations remain poorly characterized. Case reports and small series suggest a high prevalence of gastroesophageal reflux, constipation, dysphagia, and nutritional compromise ...
Mohamad Abi Nassif, Ajay Kaul, Lev Dorfman, Khalil El‐Chammas   +3 more
wiley   +1 more source

Protocol for autofluorescence-driven isolation of human peripheral blood eosinophils

STAR Protocols
Summary: Most common techniques for isolating eosinophils utilize CD16-negative selection, neglecting the CD16-positive fraction of eosinophils. Here, we present a protocol for isolating human CD16+ and CD16− eosinophils based on their autofluorescence ...
Tobias Weihrauch, Natalie Gray, N. Helge Meyer, Karin Loser, Ulrike Raap   +4 more
doaj   +1 more source

Trans-basement membrane migration of eosinophils induced by LPS-stimulated neutrophils from human peripheral blood in vitro

ERJ Open Research, 2015
In the airways of severe asthmatics, an increase of neutrophils and eosinophils is often observed despite high-dose corticosteroid therapy. We previously reported that interleukin-8-stimulated neutrophils induced trans-basement membrane migration (TBM ...
Fuyumi Nishihara, Kazuyuki Nakagome, Takehito Kobayashi, Toru Noguchi, Ryuichiro Araki, Yoshitaka Uchida, Tomoyuki Soma, Makoto Nagata   +7 more
doaj   +1 more source

The 9th International RASopathies Symposium

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The RASopathies are a group of congenital disorders with overlapping clinical manifestations that are caused by pathogenic germline or early somatic variants that result in the hyperactivation of the RAS/mitogen‐activated protein kinase (MAPK) signaling pathway.
Pau Castel, Lisa Schoyer, Beth Stronach, Raya Bogdanova, Anton M. Bennett, Jaishri Blakeley, Miriam Bornhorst, Tammy Bowers, Saskia M. Brachmann, Emma Burkitt‐Wright, Kathryn Chatfield, Alessandro De Luca, Khalil El‐Chammas, Abdul Elkadri, John E. Fortunato, Bruce D. Gelb, Anne Goriely, Karen Gripp, Kassidy Grover, Lindsay Homan, Kenneth A. Kern, Maija Kiuru, Charles (Chuck) Lawson, Yong‐Seok Lee, Frank McCormick, Gina Ney, Cristina Nuevo‐Tapioles, Sara Pardej, Elizabeth I. Pierpont, Julia Plank, Nancy Ratner, Katherine A. Rauen, J. Elliott Robinson, Les Rogers, Sarah E. Sheppard, Keir Shiels, David Stevenson, Dagmar Tiemens, Matthew Traylor, K. Nicole Weaver, Marielle Yohe, Tamar Green   +41 more
wiley   +1 more source