Results 71 to 80 of about 316,727 (384)

Eosinophils Exert Antitumorigenic Effects in the Development of Esophageal Squamous Cell CarcinomaSummary

Cellular and Molecular Gastroenterology and Hepatology, 2023
Background and Aims: Eosinophils are present in several solid tumors and have context-dependent function. Our aim is to define the contribution of eosinophils in esophageal squamous cell carcinoma (ESCC), as their role in ESCC is unknown.
Justin Jacobse, Zaryab Aziz, Lili Sun, Jasmine Chaparro, Jennifer M. Pilat, Aaron Kwag, Matthew Buendia, Mae Wimbiscus, Motomi Nasu, Tsuyoshi Saito, Shinji Mine, Hajime Orita, Frank Revetta, Sarah P. Short, M. Kay Washington, Girish Hiremath, Michael K. Gibson, Lori A. Coburn, Tatsuki Koyama, Jeremy A. Goettel, Christopher S. Williams, Yash A. Choksi   +21 more
doaj   +1 more source

Airway responses and inflammation in subjects with asthma after four days of repeated high-single-dose allergen challenge [PDF]

, 2012
Background: Both standard and low-dose allergen provocations are an established tool in asthma research to improve our understanding of the pathophysiological mechanism of allergic asthma.
Rose, Markus A., Schubert, Ralf, Schulze, Johannes, Voss, Sandra, Zielen, Stefan, Zissler, Ulrich   +5 more
core   +2 more sources

Performance Characteristics of Anti‐Collagen II Antibodies in Relapsing Polychondritis and Related Diseases: Prospective Analysis, Systematic Review, and Meta‐Analysis

Arthritis Care &Research, Accepted Article.
Background Relapsing polychondritis (RP) is a rare disease defined by recurrent cartilaginous inflammation. Anti‐collagen II (anti‐Col2) antibodies have been proposed as a diagnostic biomarker for RP, but their performance characteristics are not well defined.
Karyssa Stonick, Marcela A. Ferrada, Alice Fike, Kaitlin A. Quinn, Benjamin A. Turturice, Casey Stein, Peter C Grayson   +6 more
wiley   +1 more source

Humanized FcεRI Expressed on Mouse Eosinophils Mediates IgE-Facilitated Eosinophil Antigen Presentation

Cells
High-affinity IgE receptors (FcεRI) are expressed on human blood eosinophils and may be upregulated on eosinophils at sites of allergic inflammation including atopic dermatitis and allergic asthma.
Haibin Wang, Jean-Pierre Kinet, Peter F. Weller   +2 more
doaj   +1 more source

In vivo visualization of eosinophil secretion in eosinophilic granulomatosis with polyangiitis: An ultrastructural study

Allergology International, 2022
Background: Although eosinophilic granulomatosis with polyangiitis (EGPA) has been considered as a single disease entity belonging to anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, several studies have suggested that in addition to ...
Haruki Koike, Ryoji Nishi, Soma Furukawa, Naohiro Mouri, Yuki Fukami, Masahiro Iijima, Masahisa Katsuno   +6 more
doaj   +1 more source

Reciprocal Inhibition of Adiponectin and Innate Lung Immune Responses to Chitin and Aspergillus fumigatus [PDF]

, 2019
Chitin is a structural biopolymer found in numerous organisms, including pathogenic fungi, and recognized as an immune-stimulating pathogen associated molecular pattern by pattern recognition molecules of the host immune system.
Amarsaikhan, Nansalmaa, Gravely, Haley, Sands, Ethan M., Stolz, Dylan J., Templeton, Steven P., Tsoggerel, Angar, Wilcox, Amber   +6 more
core   +4 more sources

Development and Preliminary In Vivo Study of 3D‐Printed Bioactive Glass Scaffolds with Trabecular Architecture

Advanced Engineering Materials, EarlyView.
This study reports the fabrication of trabecular bioactive glass scaffolds (composition “1d”: 46.1SiO2‐28.7CaO‐8.8MgO‐6.2P2O5‐5.7CaF2‐4.5Na2O wt%) through vat photopolymerization and the relevant results from mechanical testing and in vivo implantation procedures in rabbit femora, showing great promise for bone tissue engineering applications.
Dilshat Tulyaganov, Roberta Gabrieli, Avzal Akbarov, Nigora Nigmatova, Bekhzod Khabilov, Alessandro Schiavi, Martin Schwentenwein, Enrica Verné, Francesco Baino   +8 more
wiley   +1 more source

Eosinophils preserve bone homeostasis by inhibiting excessive osteoclast formation and activity via eosinophil peroxidase

Nature Communications
Eosinophils are involved in tissue homeostasis. Herein, we unveiled eosinophils as important regulators of bone homeostasis. Eosinophils are localized in proximity to bone-resorbing osteoclasts in the bone marrow.
Darja Andreev, Katerina Kachler, Mengdan Liu, Zhu Chen, Brenda Krishnacoumar, Mark Ringer, Silke Frey, Gerhard Krönke, David Voehringer, Georg Schett, Aline Bozec   +10 more
doaj   +1 more source

IL-33 restricts tumor growth and inhibits pulmonary metastasis in melanoma-bearing mice through eosinophils

Oncoimmunology, 2017
The alarmin IL-33 is an IL-1 family member that stimulates pleiotropic immune reactions depending on the target tissue and microenvironmental factors.
V. Lucarini, Giovanna Ziccheddu, I. Macchia, V. La Sorsa, Francesca Peschiaroli, Carla Buccione, A. Sistigu, M. Sanchez, S. Andreone, Maria Teresa D’Urso, M. Spada, D. Macchia, C. Afferni, F. Mattei, G. Schiavoni   +14 more
semanticscholar   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source