Results 51 to 60 of about 161,284 (313)

Eosinophils Exert Antitumorigenic Effects in the Development of Esophageal Squamous Cell CarcinomaSummary

Cellular and Molecular Gastroenterology and Hepatology, 2023
Background and Aims: Eosinophils are present in several solid tumors and have context-dependent function. Our aim is to define the contribution of eosinophils in esophageal squamous cell carcinoma (ESCC), as their role in ESCC is unknown.
Justin Jacobse, Zaryab Aziz, Lili Sun, Jasmine Chaparro, Jennifer M. Pilat, Aaron Kwag, Matthew Buendia, Mae Wimbiscus, Motomi Nasu, Tsuyoshi Saito, Shinji Mine, Hajime Orita, Frank Revetta, Sarah P. Short, M. Kay Washington, Girish Hiremath, Michael K. Gibson, Lori A. Coburn, Tatsuki Koyama, Jeremy A. Goettel, Christopher S. Williams, Yash A. Choksi   +21 more
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Humanized FcεRI Expressed on Mouse Eosinophils Mediates IgE-Facilitated Eosinophil Antigen Presentation

Cells
High-affinity IgE receptors (FcεRI) are expressed on human blood eosinophils and may be upregulated on eosinophils at sites of allergic inflammation including atopic dermatitis and allergic asthma.
Haibin Wang, Jean-Pierre Kinet, Peter F. Weller   +2 more
doaj   +1 more source

Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization.

, 2022
The intestine harbors a large population of resident eosinophils, yet the function of intestinal eosinophils has not been explored. Flow cytometry and whole-mount imaging identified eosinophils residing in the lamina propria along the length of the ...
Hamelin, R., McDonald, B., Koeller, Yasmin, Petrova, T.V., Shah, Kathleen, Ignacio, Aline, Harris, Nicola L, Wang, H., Shah, K., Dufour, A., McCoy, K.D., Wong, N.C., Burkhard, R., Hamelin, Romain, Coakley, G., Burkhard, Regula, Thomson, Carolyn A, Petrova, Tatiana V, Moyat, M., Ramay, H., Wang, Haozhe, Ignacio, A., Moyat, Mati, Armand, Florence, McCoy, Kathy D, Wong, Nick C, McDonald, Braedon, Geuking, Markus B., Coakley, Gillian, Thomson, Carolyn A., Dufour, Antoine, Harris, N.L., Ramay, Hena, Geuking, Markus B, Bernier-Latmani, Jeremiah, Petrova, Tatiana, V, Armand, F., Thomson, C.A., McCoy, Kathy D., Bernier-Latmani, J., Köller, Yasmin, Köller, Y., Geuking, M.B., Wong, Nick C., Harris, Nicola L.   +44 more
core   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

Eosinophils preserve bone homeostasis by inhibiting excessive osteoclast formation and activity via eosinophil peroxidase

Nature Communications
Eosinophils are involved in tissue homeostasis. Herein, we unveiled eosinophils as important regulators of bone homeostasis. Eosinophils are localized in proximity to bone-resorbing osteoclasts in the bone marrow.
Darja Andreev, Katerina Kachler, Mengdan Liu, Zhu Chen, Brenda Krishnacoumar, Mark Ringer, Silke Frey, Gerhard Krönke, David Voehringer, Georg Schett, Aline Bozec   +10 more
doaj   +1 more source

In vivo visualization of eosinophil secretion in eosinophilic granulomatosis with polyangiitis: An ultrastructural study

Allergology International, 2022
Background: Although eosinophilic granulomatosis with polyangiitis (EGPA) has been considered as a single disease entity belonging to anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, several studies have suggested that in addition to ...
Haruki Koike, Ryoji Nishi, Soma Furukawa, Naohiro Mouri, Yuki Fukami, Masahiro Iijima, Masahisa Katsuno   +6 more
doaj   +1 more source

High Transcriptional Activity and Clinical Correlations in Eosinophils of Patients with Late-Onset Asthma

, 2023
Ting-Yu Lin,1,2 Chun-Yu Lo,1,2 Po-Jui Chang,1,2 Yu-Lun Lo,1,2 Chung-Shu Lee,1– 3 Chih-Hao Chang,1– 3 Chih-Teng Yu,1,2 Jonathan Huai Yao,1 Shu-Min Lin1,2 1Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan; 2College of Medicine,
Lo YL, Lo CY, Lin SM, Lee CS, Chang CH, Lin TY, Yu CT, Yao JH, Chang PJ   +8 more
core  

Developing and Evaluating a Laboratory‐Based Frailty Index for the Prediction of Long‐Term Health Outcomes in Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective We aimed to construct and evaluate the first laboratory‐based frailty index (FI‐Lab) for predicting adverse outcomes in systemic lupus erythematosus (SLE) and to compare its predictive ability to that of an existing clinical FI. Methods We used data from a single‐center prospective cohort of adult patients with SLE whose baseline visit ...
Grace Burns, Samuel D. Searle, Alexandra Legge   +2 more
wiley   +1 more source

Eosinophilic esophagitis [PDF]

Allergy and Asthma Proceedings, 2019
Eosinophilic esophagitis (EoE) is defined by symptoms related to esophageal dysfunction, persistent esophageal eosinophilia, and exclusion of other etiologies that may be contributing to the condition. EoE is different from erosive esophagitis. In children, symptoms vary by age groups, such as feeding disorders in 2 year olds; vomiting in 8 year olds;
Melissa M, Watts, Carol, Saltoun, Paul A, Greenberger   +2 more
openaire   +4 more sources