Results 71 to 80 of about 177,144 (212)

The Pathogenesis of Eosinophilic Esophagitis: Beyond the Eosinophil [PDF]

Digestive Diseases and Sciences, 2013
Over the past two decades, eosinophilic esophagitis (EoE) has undergone a remarkable transformation. What used to be a rare, case-reportable condition about which little was known, is now widely recognized as an important cause of upper GI morbidity and the subject of intense research activity.
openaire   +2 more sources

Human Eosinophils: Biological and Clinical Aspects

, 2000
Eosinophils represent approximately 1% of peripheral blood leukocytes and play a central proinflammatory and immunoregulatory role in various immune disorders.
Marone, G., MARONE, GIANNI
core  

The Immunosuppressive Functions of Eosinophils Are Compromised in Patients With Allergic Rhinitis, Particularly Concerning Rab27a Expression

Immunity, Inflammation and Disease
Background Eosinophils have been acknowledged to be involved in the induction of numerous inflammatory disorders. There is still a lack of knowledge about whether eosinophils play a role in immune regulation.
Yun Liao, Minyao Li, Shuo Song, Xuejie Xu, Xiaojun Xiao, Yu Liu, Gui Yang, Pingchang Yang   +7 more
doaj   +1 more source

Eosinophils Control Liver Damage by Modulating Immune Responses Against Fasciola hepatica

Frontiers in Immunology, 2020
Eosinophils are granulocytes that participate in the defense against helminth parasites and in hypersensitivity reactions. More recently, eosinophils were shown to have other immunomodulatory functions, such as tissue reparation, metabolism regulation ...
Sofía Frigerio, Valeria da Costa, Monique Costa, María Florencia Festari, Mercedes Landeira, Santiago A. Rodríguez-Zraquia, Steffen Härtel, Jorge Toledo, Teresa Freire   +8 more
doaj   +1 more source

CCL11/CCR3-dependent eosinophilia alleviates malignant pleural effusions and improves prognosis

npj Precision Oncology
Malignant pleural effusion (MPE) is a common occurrence in advanced cancer and is often linked with a poor prognosis. Eosinophils were reported to involve in the development of MPE. However, the role of eosinophils in MPE remains unclear.
Min Zhang, Lixia Xia, Wenbei Peng, Guogang Xie, Fei Li, Chao Zhang, Madiha Zahra Syeda, Yue Hu, Fen Lan, Fugui Yan, Zhangchu Jin, Xufei Du, Yinling Han, Baihui Lv, Yuejue Wang, Miao Li, Xia Fei, Yun Zhao, Kaijun Chen, Yan Chen, Wen Li, Zhihua Chen, Qiong Zhou, Min Zhang, Songmin Ying, Huahao Shen   +25 more
doaj   +1 more source

Metabolic Profiling of Human Eosinophils

Frontiers in Immunology, 2018
Immune cells face constant changes in their microenvironment, which requires rapid metabolic adaptation. In contrast to neutrophils, which are known to rely near exclusively on glycolysis, the metabolic profile of human eosinophils has not been ...
Linsey Porter, Nicole Toepfner, Kathleen R. Bashant, Jochen Guck, Margaret Ashcroft, Neda Farahi, Edwin R. Chilvers   +6 more
doaj   +1 more source

Single-cell RNA-sequencing of circulating eosinophils from asthma patients reveals an inflammatory signature

iScience
Summary: Asthma is the most common chronic lung disorder in the United States. While asthma is heterogeneous, blood eosinophils are central to the pathogenesis in most cases.
Kyndal Goss, Melanie L. Grant, Cherish Caldwell, Gail A. Dallalio, Susan T. Stephenson, Anne M. Fitzpatrick, Edwin M. Horwitz   +6 more
doaj   +1 more source

Peripheral blood eosinophils: a surrogate marker for airway eosinophilia in stable COPD. [PDF]

, 2016
INTRODUCTION: Sputum eosinophilia occurs in approximately one-third of stable chronic obstructive pulmonary disease (COPD) patients and can predict exacerbation risk and response to corticosteroid treatments. Sputum induction, however, requires expertise,
Gibson, PG, Gibson PG, Negewo, NA, Jones, PW, Simpson, JL, Wark PAB, Wark, PA, Baines, KJ, Negewo NA, Simpson JL, Baines KJ, Jones PW, McDonald VM, McDonald, VM   +13 more
core   +1 more source

Trans-basement membrane migration of eosinophils induced by LPS-stimulated neutrophils from human peripheral blood in vitro

ERJ Open Research, 2015
In the airways of severe asthmatics, an increase of neutrophils and eosinophils is often observed despite high-dose corticosteroid therapy. We previously reported that interleukin-8-stimulated neutrophils induced trans-basement membrane migration (TBM ...
Fuyumi Nishihara, Kazuyuki Nakagome, Takehito Kobayashi, Toru Noguchi, Ryuichiro Araki, Yoshitaka Uchida, Tomoyuki Soma, Makoto Nagata   +7 more
doaj   +1 more source

Use of 111-Indium–labeled autologous eosinophils to establish the in vivo kinetics of human eosinophils in healthy subjects

, 2012
Eosinophils are the major cellular effectors of allergic inflammation and represent an important therapeutic target. Whilst the genesis and activation of eosinophils has been extensively explored, little is known about their intravascular kinetics or ...
Prina Ruparelia (16049714), Nanak R. Singh, Kishor Solanki, Chandra K Solanki (16149635), A. Michael Peters, Nanak R Singh (16149629), Sarah Heard (16009443), Charlotte Summers, Kottekkattu K Balan (16149641), Neda Farahi, Chrystalla Loutsios, Sarah Heard, Charlotte Summers (10956624), Kottekkattu K. Balan, Edwin R. Chilvers, Kishor Solanki (16149638), Edwin R Chilvers (16149647), Alison M. Condliffe, Neda Farahi (5431109), A Michael Peters (16048256), Chrystalla Loutsios (16149632), Alison M Condliffe (16149644), Chandra K. Solanki, Prina Ruparelia   +23 more
core   +1 more source