Results 71 to 80 of about 19,297 (197)

Localized Periodontitis in Young Individuals: Aggregatibacter JP2 Clone, Immunological Dysfunctions and Other Stories

Journal of Periodontal Research, EarlyView.
This review describes the features of grade C molar‐incisor pattern periodontitis and discusses the role of A. actinomycetemcomitans in its pathogenesis and why molars and incisors are preferably affected. Possible future studies on this aggressive disease in primary and permanent dentition and emerging omics techniques for diagnosis and management are
Luigi Nibali, Meaad M. Alamri, Manuela Maria Viana Miguel, Luciana Shaddox   +3 more
wiley   +1 more source

Peripheral Inflammation and Sleep Loss Induce Coordinated Motivational Changes: An Experimental Two‐Hit Stress Model

Journal of Sleep Research, EarlyView.
ABSTRACT Sleep loss and low‐grade inflammation are common stressors that affect behaviour and recovery needs. To examine their separate and combined effects on motivation for everyday behaviours, we developed a two‐hit experimental model. Participants (N = 56, 31 women) completed three experimental visits: sleep saturation (two nights, 9 h in bed/night)
John Axelsson, Mats Lekander, Camilla I. Svensson, Nils Simon, Alexandra Kuliszkiewicz, Julie Lasselin, Leonie J. T. Balter   +6 more
wiley   +1 more source

Rhinovirus infection up‐regulates eotaxin and eotaxin‐2 expression in bronchial epithelial cells

Clinical & Experimental Allergy, 2001
Background Human rhinoviruses (RVs) are the most common precipitants of asthma exacerbations. RV infection of bronchial epithelium results in local airway inflammation inducing eosinophil recruitment and activation. Induction of eosinophil chemoattractants could represent a central mechanism, as well as a prime target for intervention.Objective To ...
PAPADOPOULOS NG, PAPI, Alberto, MEYER J, STANCIU LA, SALVI S, HOLGATE ST, JOHNSTON SL   +6 more
openaire   +3 more sources

Effects of photobiomodulation therapy on pulmonary inflammation in chronic asthma: Dosimetric study in an experimental model

Photochemistry and Photobiology, EarlyView.
Photobiomodulation therapy (PBMT) was evaluated across a radiant energy range (1–7.5 J) in a murine model of chronic ovalbumin‐induced asthma to identify the optimal therapeutic dose. PBMT attenuated airway inflammation and remodelling, suppressed Th2 cytokines, and enhanced regulatory immune responses, highlighting a dose‐dependent immunomodulatory ...
Tawany Gonçalves Santos, Cintia Estefano Alves, Aurileia Aparecida de Brito, Bibiana Padilha de Menezes da Silva, Cinthya Cosme Gutierrez Duran, Stella Zamuner, Rodrigo Labat, José Antonio Silva Junior, Maria Cristina Chavantes, Flavio Aimbire, Renata Kelly da Palma, Ana Paula Ligeiro de Oliveira   +11 more
wiley   +1 more source

Regulation of Eosinophil and Group 2 Innate Lymphoid Cell Trafficking in Asthma

Frontiers in Medicine, 2017
Asthma is an inflammatory disease usually characterized by increased Type 2 cytokines and by an infiltration of eosinophils to the airways. While the production of Type 2 cytokines has been associated with TH2 lymphocytes, increasing evidence indicates ...
Marie-Chantal Larose, Anne-Sophie Archambault, Véronique Provost, Michel Laviolette, Nicolas Flamand   +4 more
doaj   +1 more source

Differential intestinal injury and unchanged systemic inflammatory responses to leg and whole‐body passive hyperthermia in healthy humans

Experimental Physiology, EarlyView.
Abstract Hyperthermia can cause intestinal injury, facilitating endotoxin translocation and an inflammatory response that has been associated with heat illness. However, the potential occurrence of these responses has been incompletely reported during passive hyperthermia, and the independent effect of hyperthermia is equivocal.
Oliver R. Gibson, Orlando Laitano, Kazuhito Watanabe, José González‐Alonso   +3 more
wiley   +1 more source

Elevated Plasma Chemokines for Eosinophils in Neuromyelitis Optica Spectrum Disorders during Remission

Frontiers in Neurology, 2018
BackgroundA prominent pathological feature of neuromyelitis optica spectrum disorders (NMOSD) is markedly greater eosinophilic infiltration than that seen in other demyelinating diseases, like multiple sclerosis (MS).
Yanping Tong, Yanping Tong, Tao Yang, Tao Yang, Jingwen Wang, Tianyou Zhao, Lei Wang, Yuezhi Kang, Cuicui Cheng, Yongping Fan, Yongping Fan   +10 more
doaj   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

Interleukin-19 Downregulates Interleukin-4-Induced Eotaxin Production in Human Nasal Fibroblasts

Allergology International, 2011
Background: Interleukin-19 (IL-19), a member of the IL-10 family, is characterized as the cytokine suppressing the release and function of several proinflammatory cytokines.
Masaaki Higashino, Tetsuji Takabayashi, Noboru Takahashi, Masayuki Okamoto, Norihiko Narita, Akihiro Kojima, Sawako Hyo, Ryo Kawata, Hiroshi Takenaka, Shigeharu Fujieda   +9 more
doaj   +1 more source

Chemokines in Alzheimer's Disease: Early Defence, Late Damage and the Impact of Sex and Infection

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 2, August 2026.
ABSTRACT Chemokines constitute a versatile signalling network maintaining homeostasis and glia–neuron communication in the healthy brain but become progressively dysregulated during aging and Alzheimer's disease (AD). This review examines how chemokine systems transition from tightly regulated homeostatic signals to drivers of chronic neuroinflammation
Blanca I. Aldana, Kristine Freude
wiley   +1 more source