Signalling, cell cycle and pluripotency in embryonic stem cells [PDF]
, 2002 International ...
Burdon, Tom +2 more
core +1 more source
The Origin of Endoderm: Transmission Electron Microscopic Point of View
Siriraj Medical Journal, 2020 Objective: To show the transmission electron microscopic (TEM) evidence to confirm that the endoderm originates from the epiblast of the primitive streak or from other sources.
Jantima Roongruangchai +2 more
doaj
Stem Cell Research, 2021 The tyrosine kinase Src is highly expressed in embryonic stem cells (ESCs) and ESC-differentiated cells, however, its functional role remains obscured. Here, we constitutively expressed Src in mouse ESCs and found these cells retained comparable levels ...
Juan Luo, Hailin Zou, Peng Li
doaj
Distribution of tissue progenitors within the shield region of the zebrafish gastrula [PDF]
, 1995 The zebrafish has emerged as an important model system for the experimental analysis of vertebrate development because it is amenable to genetic analysis and because its optical clarity allows the movements and the differentiation of individual cells to ...
Fraser, Scott E., Shih, John
core
Dissecting the dynamics of signaling events in the BMP, WNT, and NODAL cascade during self-organized fate patterning in human gastruloids. [PDF]
, 2019 During gastrulation, the pluripotent epiblast self-organizes into the 3 germ layers-endoderm, mesoderm and ectoderm, which eventually form the entire embryo.
Chhabra, Sapna +4 more
core +1 more source
Signaling Centers Drive Brachyury Dynamics and Lineage Commitment in mESC Aggregates
FASEB BioAdvances, Volume 7, Issue 6, June 2025.We used a mouse embryonic stem cell aggregate model to compare the use of Chiron and BMP4 signaling as pulses (applied to the whole aggregate) or signaling centers (applied to part of the aggregate). BMP4 as a pulse was shown to drive neural differentiation, with Chiron inhibiting this effect.
A. Rabeling, M. Goolam
wiley +1 more source
Dynamics of Wnt activity on the acquisition of ectoderm potency in epiblast stem cells
Development, 2019 During embryogenesis, the stringent regulation of Wnt activity is crucial for the morphogenesis of the head and brain. The loss of function of the Wnt inhibitor Dkk1 results in elevated Wnt activity, loss of ectoderm lineage attributes from the anterior ...
P. Osteil +12 more
semanticscholar +1 more source
Advanced Science, Volume 12, Issue 17, May 8, 2025.A critical aspect of chromosomal remodeling in small molecule‐induced multilineage trans‐differentiation(iMT) is elucidated. A dynamic atlas spanning over 35 days profiles terminal trans‐differentiated cells, which reverted to a more youthful state. This study reveals parallels between iMT and other cell fate determination processes, emphasizing an ...
Weigao E +13 more
wiley +1 more source
In Vivo Differentiation Potential of Epiblast Stem Cells Revealed by Chimeric Embryo Formation
Cell Reports, 2012 Chimera formation after blastocyst injection or morula aggregation is the principal functional assay of the developmental potential of mouse embryonic stem cells (ESCs).
Yali Huang +3 more
doaj +1 more source
Cell lineage specific distribution of H3K27 trimethylation accumulation in an in vitro model for human implantation. [PDF]
PLoS ONE, 2012 Female mammals inactivate one of their two X-chromosomes to compensate for the difference in gene-dosage with males that have just one X-chromosome. X-chromosome inactivation is initiated by the expression of the non-coding RNA Xist, which coats the X ...
Gijs Teklenburg +7 more
doaj +1 more source