Results 81 to 90 of about 10,608 (175)

Epiblast Ground State Is Controlled by Canonical Wnt/β-Catenin Signaling in the Postimplantation Mouse Embryo and Epiblast Stem Cells

PLoS ONE, 2013
Epiblast stem cells (EpiSCs) are primed pluripotent stem cells and can be derived from postimplantation mouse embryos. We now show that the absence of canonical Wnt/β-catenin signaling is essential for maintenance of the undifferentiated state in mouse EpiSCs and in the epiblast of mouse embryos.
Tomoyuki Sumi, Shinya Oki, Keiko Kitajima, Chikara Meno   +3 more
openaire   +4 more sources

A human epiblast model reveals dynamic TGFβ-mediated control of epithelial identity during mammalian epiblast development

Nature Cell Biology
Pluripotency, the ability to generate all body cell types, emerges in a disorganized embryonic cell mass. After implantation, these cells form a columnar epithelium and initiate lumenogenesis. During gastrulation, some undergo epithelial-to-mesenchymal transition to form the primitive streak (PS).
Irene Zorzan, Elena Carbognin, Andrea Lauria, Valentina Proserpio, Davide Benvegnù, Federica Bertelli, Susana De Juambelz Urías, Caterina Dalrio, Giorgia Panebianco, Rebecca Scarfò, Eleonora Pensabene, Mattia Arboit, Irene Paolucci, Andrea Drusin, Dario Bizzotto, Monika Sledziowska, Paola Braghetta, Andrea Ditadi, Gianluca Amadei, Salvatore Oliviero, Graziano Martello   +20 more
openaire   +2 more sources

Developmental origins of pregnancy loss in cattle. [PDF]

Anim Reprod
Flores-Borobia I, Pérez-Gómez A, Martínez de Los Reyes N, González-Brusi L, Galiano-Cogolludo B, Irala C, Siegmund-Sabater A, Ramos-Ibeas P, Bermejo-Álvarez P.   +8 more
europepmc   +1 more source

Boundary geometry controls a topological defect transition that determines lumen nucleation in embryonic development. [PDF]

Nat Mater
Guruciaga PC, Ichikawa T, Plunder S, Hiiragi T, Erzberger A.   +4 more
europepmc   +1 more source

AXIN1 and AXIN2 regulate the WNT-signaling landscape to promote distinct mesoderm programs. [PDF]

Dev Cell
Hernández-Martínez R, Nowotschin S, Harland LTG, Kuo YY, Theeuwes B, Göttgens B, Lacy E, Hadjantonakis AK, Anderson KV.   +8 more
europepmc   +1 more source

Base editing reveals an essential role for NANOG in human embryogenesis. [PDF]

Nature
Bower OJ, R Orsi AE, McMahon R, Staneva D, Blagrove JR, Singh K, Simon CS, McCarthy A, Garcia P, Shaikly V, Taranissi M, Wilding M, Serhal P, Odia RA, Vasilic M, Choudhary M, Papathanasiou A, Elder K, Snell P, Christie L, Arbab M, Liu DR, Herbert M, Harasimov K, Niakan KK.   +24 more
europepmc   +1 more source

Human stem cell-based embryo models: from self-organization to recapitulating development. [PDF]

Front Cell Dev Biol
Liu D, He T.
europepmc   +1 more source

Mammalian DNA methyltransferases in DNA methylation and imprinted gene expression in extraembryonic ectoderm of post-implantation embryos. [PDF]

J Biol Chem
Lu T, Li Y, Wen Y, Xu Z, Lin H, Shao G, Li X.   +6 more
europepmc   +1 more source

Conserved and divergent DNA methylation features of extraembryonic tissues between human, mouse and chicken. [PDF]

BMC Genomics
Lea G, Gu Y, Xiong F, Hanna CW.
europepmc   +1 more source

Primate embryoids: an in vitro model leading from a totipotency-like phase to early organogenesis. [PDF]

Signal Transduct Target Ther
Tara A, Kues WA.
europepmc   +1 more source