Results 61 to 70 of about 10,608 (175)

RLIM‐associated neurodevelopmental disorders: From clinical spectrum to molecular mechanisms

The FEBS Journal, EarlyView.
RLIM (RNF12) is an E3 ubiquitin ligase essential for mammalian development. Loss‐of‐function variants cause Tønne–Kalscheuer syndrome, while duplications cause Xq13 duplication syndrome, highlighting RLIM dosage sensitivity. This review summarizes the genetics, clinical features, and molecular mechanisms of RLIM‐associated disorders, integrating ...
Madison Landon, Kyra Swildens, Vera M. Kalscheuer, Cristina Gontan, Francisco Bustos   +4 more
wiley   +1 more source

A Primary Role for the Tsix lncRNA in Maintaining Random X-Chromosome Inactivation

Cell Reports, 2015
Differentiating pluripotent epiblast cells in eutherians undergo random X-inactivation, which equalizes X-linked gene expression between the sexes by silencing one of the two X-chromosomes in females. Tsix RNA is believed to orchestrate the initiation of 
Srimonta Gayen, Emily Maclary, Emily Buttigieg, Michael Hinten, Sundeep Kalantry   +4 more
doaj   +1 more source

Reviewing the benefits and clinical outcomes of oral fibroblasts over mesenchymal stem cells for repairing periodontal defects during or after orthodontic tooth movement

Periodontology 2000, EarlyView.
Abstract Orthodontic therapy applies forces to teeth, causing an inflammatory reaction in the periodontal ligament. This is repaired by remodeling of the periodontium, allowing tooth displacement. Although orthodontic therapy is mostly initiated during childhood and adolescence, the number of adults seeking this treatment is increasing as our society's
Ludovica Parisi, Eleni Mavrogonatou, Anton Sculean, Dimitris Kletsas, Martin Degen   +4 more
wiley   +1 more source

Cynomolgus Monkey (Macaca fascicularis) Embryo Models: From Developmental Benchmarks to Functionally Testable Embryoids

Journal of Medical Primatology, Volume 55, Issue 6, December 2026.
ABSTRACT Stem cell‐based embryo models now reconstruct increasingly advanced stages of mammalian development, but developmental fidelity remains a central limitation. This review examines why cynomolgus monkey systems are biologically necessary, how natural embryos and emerging technologies benchmark primate development, and how advanced monkey ...
Yeojeong Jeong, Jongwon Byun, Sung‐Hwan Moon, Taeho Kwon   +3 more
wiley   +1 more source

Tracing and Capturing the Epiblast Pluripotency of Sheep Preimplantation Embryos

Advanced Science
Capturing different pluripotent state stem cells from epiblast in vitro helps understand embryonic development and provides invaluable cell sources for basic research and regenerative medicine.
Jinying Zhang, Runbo Li, Ruijie Luo, Qiang Zhang, Zimo Zhao, Haishen Xu, Minglei Zhi, Wenjie Jiang, Meng Wang, Xinze Chen, Zhiqiang Feng, Yingjie Wang, Yuhan Yang, Pengcheng He, Hanyue Su, Tianzhi Chen, Shunxin Wang, Yixuan Yao, Jinghui Yang, Fan Zhao, Tingting Li, Haitao Wang, Xiaosheng Zhang, Jinlong Zhang, Qiuyue Liu, Shuai Gao, Yuchang Yao, Jianyong Han, Suying Cao   +28 more
doaj   +1 more source

Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells [PDF]

Development, 2012
Somatic development initiates from the epiblast in post-implantation mammalian embryos. Recent establishment of epiblast stem cell (EpiSC) lines has opened up new avenues of investigation of the mechanisms that regulate the epiblast state and initiate lineage-specific somatic development.
Makiko, Iwafuchi-Doi, Kazunari, Matsuda, Kazuhiro, Murakami, Hitoshi, Niwa, Paul J, Tesar, Jun, Aruga, Isao, Matsuo, Hisato, Kondoh   +7 more
openaire   +2 more sources

Specific epiblast loss and hypoblast impairment in cattle embryos sensitized to survival signalling by ubiquitous overexpression of the proapoptotic gene BAD.

PLoS ONE, 2014
Early embryonic lethality is common, particularly in dairy cattle. We made cattle embryos more sensitive to environmental stressors by raising the threshold of embryo survival signaling required to overcome the deleterious effects of overexpressing the ...
Jessica van Leeuwen, Debra K Berg, Craig S Smith, David N Wells, Peter L Pfeffer   +4 more
doaj   +1 more source

The Origin of Endoderm: Transmission Electron Microscopic Point of View

Siriraj Medical Journal, 2020
Objective: To show the transmission electron microscopic (TEM) evidence to confirm that the endoderm originates from the epiblast of the primitive streak or from other sources.
Jantima Roongruangchai, Kosol Roongruangchai, Ratirat Kolaka   +2 more
doaj  

Ultrasound‐Actuated Gene Editing in Human Kidney Organoids

Advanced Science, Volume 13, Issue 49, 3 September 2026.
Peptide‐stabilized nanoemulsions enable spatially controlled, ultrasound‐triggered delivery of gene‐editing proteins deep within human kidney organoid tissues. Focused acoustic pulses drive droplet vaporization, propelling cargo into target renal cells while preserving native tissue microarchitecture. This non‐viral platform improves both the depth and
Michael A. Miller, Nicole Vo, Utkarsh, Ivan Sokirniy, Justin Pritchard, Benjamin S. Freedman, Scott H. Medina   +6 more
wiley   +1 more source

Morphological and Gene Expression Changes in Cattle Embryos from Hatched Blastocyst to Early Gastrulation Stages after Transfer of In Vitro Produced Embryos. [PDF]

PLoS ONE, 2015
A detailed morphological staging system for cattle embryos at stages following blastocyst hatching and preceding gastrulation is presented here together with spatiotemporal mapping of gene expression for BMP4, BRACHYURY, CERBERUS1 (CER1), CRIPTO ...
Jessica van Leeuwen, Debra K Berg, Peter L Pfeffer   +2 more
doaj   +1 more source