Results 41 to 50 of about 24,553 (253)
Distinct modes of floor plate induction in the chick embryo [PDF]
, 2003 To begin to reconcile models of floor plate formation in the vertebrate neural tube, we have performed experiments aimed at understanding the development of the early floor plate in the chick embryo. Using real-time analyses of cell behaviour, we provide
Fraser, Scott +4 more
core +1 more source
Transcription factor heterogeneity and epiblast pluripotency [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2011 Stem cells are defined by the simultaneous possession of the seemingly incongruent properties of self-renewal and multi-lineage differentiation potential. To maintain a stem cell population, these opposing forces must be balanced. Transcription factors that function to direct pluripotent cell identity are not all equally distributed throughout the ...
Osorno, R., Chambers, I.
openaire +2 more sources
Nanog regulates Pou3f1 expression at the exit from pluripotency during gastrulation
Biology Open, 2019 Pluripotency is regulated by a network of transcription factors that maintain early embryonic cells in an undifferentiated state while allowing them to proliferate.
Antonio Barral +11 more
doaj +1 more source
Controlled modeling of human epiblast and amnion development using stem cells
Nature, 2019 Early human embryonic development involves extensive lineage diversification, cell-fate specification and tissue patterning1. Despite its basic and clinical importance, early human embryonic development remains relatively unexplained owing to ...
Yi Zheng +10 more
semanticscholar +1 more source
NaNog: A pluripotency homeobox (master) molecule. [PDF]
, 2015 One of the most intriguing aspects of cell biology is the state of pluripotency, where the cell is capable of self-renewal for as many times as deemed necessary , then at a specified time can differentiate into any type of cell. This fundamental process
Aguib, YE +4 more
core +1 more source
YAP establishes epiblast responsiveness to inductive signals for germ cell fate
Development, 2021 The germ cell lineage in mammals is induced by the stimulation of pluripotent epiblast cells by signaling molecules. Previous studies have suggested that the germ cell differentiation competence or responsiveness of epiblast cells to signaling molecules ...
Saya Kagiwada +9 more
semanticscholar +1 more source
Epigenetic regulation of gene expression in porcine epiblast, hypoblast, trophectoderm and epiblast-derived neural progenitor cells [PDF]
Epigenetics, 2011 After fertilization, lineage specification is governed by a complicated molecular network in which permissiveness and repression of expression of pluripotency- and differentiation-associated genes are regulated by epigenetic modifications. DNA methylation operates as a very stable repressive mark in this process.
Gao, Yu +6 more
openaire +4 more sources
Stem Cell Research, 2021 The tyrosine kinase Src is highly expressed in embryonic stem cells (ESCs) and ESC-differentiated cells, however, its functional role remains obscured. Here, we constitutively expressed Src in mouse ESCs and found these cells retained comparable levels ...
Juan Luo, Hailin Zou, Peng Li
doaj +1 more source
Nature, 1963 THE homologies of the various organs of the graminaceous embryo and caryopsis have been the subject of much debate in the past. Jacques-Felix1, who recently summarized again the various theories, has suggested that the epiblast is the sole leaf of the primary axis or ‘protocorm’; other theories give the epiblast the status of an auricle, or a cotyledon.
openaire +1 more source
Stable Methylation at Promoters Distinguishes Epiblast Stem Cells from Embryonic Stem Cells and the In Vivo Epiblasts [PDF]
Stem Cells and Development, 2014 Embryonic Stem Cells (ESCs) and Epiblast Stem Cells (EpiSCs) are the in vitro representatives of naïve and primed pluripotency, respectively. It is currently unclear how their epigenomes underpin the phenotypic and molecular characteristics of these distinct pluripotent states. Here, we performed a genome-wide comparison of DNA methylation between ESCs
Veillard, Anne-Clémence +11 more
openaire +5 more sources