Results 31 to 40 of about 10,608 (175)
Transcription factor heterogeneity and epiblast pluripotency [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2011 Stem cells are defined by the simultaneous possession of the seemingly incongruent properties of self-renewal and multi-lineage differentiation potential. To maintain a stem cell population, these opposing forces must be balanced. Transcription factors that function to direct pluripotent cell identity are not all equally distributed throughout the ...
Osorno, R., Chambers, I.
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Frontiers in Cell and Developmental Biology, 2020 Murine development demands that pluripotent epiblast stem cells in the peri-implantation embryo increase from approximately 120 to 14,000 cells between embryonic days (E) 4.5 and E7.5. This is possible because epiblast stem cells can complete cell cycles
Georgia R. Kafer, Anthony J. Cesare
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Gastrulation EMT Is Independent of P-Cadherin Downregulation. [PDF]
PLoS ONE, 2016 Epithelial-mesenchymal transition (EMT) is an evolutionarily conserved process during which cells lose epithelial characteristics and gain a migratory phenotype.
Pricila K Moly +4 more
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Nature, 1963 THE homologies of the various organs of the graminaceous embryo and caryopsis have been the subject of much debate in the past. Jacques-Felix1, who recently summarized again the various theories, has suggested that the epiblast is the sole leaf of the primary axis or ‘protocorm’; other theories give the epiblast the status of an auricle, or a cotyledon.
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eLife, 2015 Early mouse development is accompanied by dynamic changes in chromatin modifications, including G9a-mediated histone H3 lysine 9 dimethylation (H3K9me2), which is essential for embryonic development.
Jan J Zylicz +6 more
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Nanog regulates Pou3f1 expression at the exit from pluripotency during gastrulation
Biology Open, 2019 Pluripotency is regulated by a network of transcription factors that maintain early embryonic cells in an undifferentiated state while allowing them to proliferate.
Antonio Barral +11 more
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Sox2 Level Is a Determinant of Cellular Reprogramming Potential. [PDF]
PLoS ONE, 2013 Epiblast stem cells (EpiSCs) and embryonic stem cells (ESCs) differ in their in vivo differentiation potential. While ESCs form teratomas and efficiently contribute to the development of chimeras, EpiSCs form teratomas but very rarely chimeras.
Dong Wook Han +7 more
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Epigenetic regulation of gene expression in porcine epiblast, hypoblast, trophectoderm and epiblast-derived neural progenitor cells [PDF]
Epigenetics, 2011 After fertilization, lineage specification is governed by a complicated molecular network in which permissiveness and repression of expression of pluripotency- and differentiation-associated genes are regulated by epigenetic modifications. DNA methylation operates as a very stable repressive mark in this process.
Gao, Yu +6 more
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Stable Methylation at Promoters Distinguishes Epiblast Stem Cells from Embryonic Stem Cells and the In Vivo Epiblasts [PDF]
Stem Cells and Development, 2014 Embryonic Stem Cells (ESCs) and Epiblast Stem Cells (EpiSCs) are the in vitro representatives of naïve and primed pluripotency, respectively. It is currently unclear how their epigenomes underpin the phenotypic and molecular characteristics of these distinct pluripotent states. Here, we performed a genome-wide comparison of DNA methylation between ESCs
Veillard, Anne-Clémence +11 more
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Stem Cell Research, 2021 The tyrosine kinase Src is highly expressed in embryonic stem cells (ESCs) and ESC-differentiated cells, however, its functional role remains obscured. Here, we constitutively expressed Src in mouse ESCs and found these cells retained comparable levels ...
Juan Luo, Hailin Zou, Peng Li
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