Results 11 to 20 of about 24,553 (253)

Suppression of ERK signalling promotes pluripotent epiblast in the human blastocyst [PDF]

Nature Communications
Studies in the mouse demonstrate the importance of fibroblast growth factor (FGF) and extra-cellular receptor tyrosine kinase (ERK) in specification of embryo-fated epiblast and yolk-sac-fated hypoblast cells from uncommitted inner cell mass (ICM) cells ...
Claire S. Simon, Afshan McCarthy, Laura Woods, Desislava Staneva, Martin Proks, Nazmus Salehin, Georgia Lea, Qiulin Huang, Madeleine Linneberg-Agerholm, Alex Faulkner, Athanasios Papathanasiou, Kay Elder, Phil Snell, Leila Christie, Patricia Garcia, Valerie Shaikly, Mohamed Taranissi, Meenakshi Choudhary, Mary Herbert, Courtney W. Hanna, Joshua M. Brickman, Kathy K. Niakan   +21 more
doaj   +3 more sources

An in vitro stem cell model of human epiblast and yolk sac interaction

eLife, 2021
Human embryogenesis entails complex signalling interactions between embryonic and extra-embryonic cells. However, how extra-embryonic cells direct morphogenesis within the human embryo remains largely unknown due to a lack of relevant stem cell models ...
Kirsty ML Mackinlay, Bailey AT Weatherbee, Viviane Souza Rosa, Charlotte E Handford, George Hudson, Tim Coorens, Lygia V Pereira, Sam Behjati, Ludovic Vallier, Marta N Shahbazi, Magdalena Zernicka-Goetz   +10 more
doaj   +2 more sources

NANOG initiates epiblast fate through the coordination of pluripotency genes expression

Nature Communications, 2022
Pluripotent epiblast cells segregate from primitive endoderm in the blastocyst inner cell mass (ICM). Here the authors show that mosaic epiblast differentiation during mouse and human preimplantation development initiates stochastically in ICM ...
Nicolas Allègre, Sabine Chauveau, Cynthia Dennis, Yoan Renaud, Dimitri Meistermann, Lorena Valverde Estrella, Pierre Pouchin, Michel Cohen-Tannoudji, Laurent David, Claire Chazaud   +9 more
doaj   +2 more sources

Live imaging and functional characterization of the avian hypoblast redefine the mechanisms of primitive streak induction [PDF]

Nature Communications
In birds and mammals, the formation of the primitive streak, the hallmark of the primary axis and site of gastrulation, is thought to occur when the anterior displacement of the hypoblast (visceral endoderm in mice) lifts its inhibition on NODAL ...
Aurélien Villedieu, Olinda Alegria-Prévot, Carole Phan, Yu Ieda, Francis Corson, Jérôme Gros   +5 more
doaj   +3 more sources

Computational modelling unveils how epiblast remodelling and positioning rely on trophectoderm morphogenesis during mouse implantation.

PLoS ONE, 2021
Understanding the processes by which the mammalian embryo implants in the maternal uterus is a long-standing challenge in embryology. New insights into this morphogenetic event could be of great importance in helping, for example, to reduce human ...
Joel Dokmegang, Moi Hoon Yap, Liangxiu Han, Matteo Cavaliere, René Doursat   +4 more
doaj   +2 more sources

Tracing and Capturing the Epiblast Pluripotency of Sheep Preimplantation Embryos [PDF]

Advanced Science
Capturing different pluripotent state stem cells from epiblast in vitro helps understand embryonic development and provides invaluable cell sources for basic research and regenerative medicine.
Jinying Zhang, Runbo Li, Ruijie Luo, Qiang Zhang, Zimo Zhao, Haishen Xu, Minglei Zhi, Wenjie Jiang, Meng Wang, Xinze Chen, Zhiqiang Feng, Yingjie Wang, Yuhan Yang, Pengcheng He, Hanyue Su, Tianzhi Chen, Shunxin Wang, Yixuan Yao, Jinghui Yang, Fan Zhao, Tingting Li, Haitao Wang, Xiaosheng Zhang, Jinlong Zhang, Qiuyue Liu, Shuai Gao, Yuchang Yao, Jianyong Han, Suying Cao   +28 more
doaj   +2 more sources

Large‐Scale Bioprinting of Human Epiblast‐Like Models Featuring Disc‐Shaped Morphogenesis and Gastrulation Events [PDF]

Advanced Science
Understanding the initial weeks of human development remains challenging due to ethical concerns and the restricted availability of human embryos.
Yixue Luo, Liheng Luo, Ling Wang, Shanshan Yang, Hongan Ren, Shaojun Liang, Xiaoyu Wang, Yijun Su, Leqian Yu, Xiaoyue Wang, Mingen Xu, Rui Yao   +11 more
doaj   +2 more sources

Reprogramming of rabbit induced pluripotent stem cells toward epiblast and chimeric competency using Krüppel-like factors

Stem Cell Research, 2017
Rabbit induced pluripotent stem cells (rbiPSCs) possess the characteristic features of primed pluripotency as defined in rodents and primates. In the present study, we reprogrammed rbiPSCs using human Krüppel-like factors (KLFs) 2 and 4 and cultured them
Yann Tapponnier, Marielle Afanassieff, Irène Aksoy, Maxime Aubry, Anaïs Moulin, Lucas Medjani, Wilhelm Bouchereau, Chloé Mayère, Pierre Osteil, Jazmine Nurse-Francis, Ioannis Oikonomakos, Thierry Joly, Luc Jouneau, Catherine Archilla, Barbara Schmaltz-Panneau, Nathalie Peynot, Harmonie Barasc, Alain Pinton, Jérome Lecardonnel, Elen Gocza, Nathalie Beaujean, Véronique Duranthon, Pierre Savatier   +22 more
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The potent neuroepithelium-promoting activity of Otx2 during gastrulation, as demonstrated by its exogenous epiblast-wide expression in chicken embryos [PDF]

Frontiers in Cell and Developmental Biology
Although Otx2 has been a topic of research for over 3 decades, the role of Otx2 expressed in the brain-forming anterior epiblast during gastrulation has not been clarified.
Naoya Takami, Kagayaki Kato, Koya Yoshihi, Akihito Kawamura, Hideaki Iida, Hisato Kondoh, Hisato Kondoh   +6 more
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Hypoblast from human pluripotent stem cells regulates epiblast development

Nature, 2023
Recently, several studies using cultures of human embryos together with single-cell RNA-seq analyses have revealed differences between humans and mice, necessitating the study of human embryos1–8.
Takumi Okubo, N. Rivron, Mio Kabata, Hideki Masaki, Keiko Kishimoto, Katsunori Semi, May Nakajima‐Koyama, Haruko Kunitomi, Belinda Kaswandy, Hideyuki Sato, Hiromitsu Nakauchi, K. Woltjen, Mitinori Saitou, Erika Sasaki, Takuya Yamamoto, Yasuhiro Takashima   +15 more
semanticscholar   +1 more source