Results 11 to 20 of about 10,397 (178)
Epiblast lumenogenesis is not a mammalian-specific trait
Nature CommunicationsEpiblast lumenogenesis is a hallmark of mammalian embryogenesis, and crucial for the subsequent processes of anterior-posterior patterning and gastrulation.
Antonia Weberling +8 more
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Frontiers in Cell and Developmental Biology, 2023 Embryonic stem cell (ESC) derivation from single blastomeres of 8-cell mouse embryos results in lower derivation rates than that from whole blastocysts, raising a biological question about the developmental potential of sister blastomeres.
Sandra Alonso-Alonso +9 more
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Cell Reports, 2021 Summary: At implantation, the embryo establishes contacts with the maternal endometrium. This stage is associated with a high incidence of preclinical pregnancy losses. While the maternal factors underlying uterine receptivity have been investigated, the
Matteo Amitaba Molè +5 more
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Frontiers in Cell and Developmental Biology, 2021 From fertilization to onset of gastrulation, a mammalian embryo goes through several rounds of cellular morphogenesis resembling phenomena of epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET), collectively referred to as
Galym Ismagulov +2 more
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An in vitro stem cell model of human epiblast and yolk sac interaction
eLife, 2021 Human embryogenesis entails complex signalling interactions between embryonic and extra-embryonic cells. However, how extra-embryonic cells direct morphogenesis within the human embryo remains largely unknown due to a lack of relevant stem cell models ...
Kirsty ML Mackinlay +10 more
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Rat epiblast-derived stem cells recapitulate the attributes of pre-gastrulation epiblast
Cell Reports Methods, 2023 Iwatsuki and colleagues have generated self-renewing pluripotent stem cells from the pre-gastrulation epiblast of the rat embryo and from other cellular sources: rat embryonic stem cells (rESCs) and epiblast-like cells derived from the rESCs. These rat epiblast-derived stem cells (rEpiSCs) display germ-line competence that is characteristic of mouse ...
V. Pragathi Masamsetti, Patrick P.L. Tam
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BMC Biology, 2022 Background During mammalian preimplantation development, as the fertilized egg develops and differentiates, three cell lineages become specified: trophectoderm (TE), epiblast, and primitive endoderm (PrE).
Mami Tsume-Kajioka +4 more
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eLife, 2018 During gastrulation epiblast cells exit pluripotency as they specify and spatially arrange the three germ layers of the embryo. Similarly, human pluripotent stem cells (PSCs) undergo spatially organized fate specification on micropatterned surfaces ...
Sophie M Morgani +4 more
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Frontiers in Cell and Developmental Biology, 2020 Murine development demands that pluripotent epiblast stem cells in the peri-implantation embryo increase from approximately 120 to 14,000 cells between embryonic days (E) 4.5 and E7.5. This is possible because epiblast stem cells can complete cell cycles
Georgia R. Kafer, Anthony J. Cesare
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Gastrulation EMT Is Independent of P-Cadherin Downregulation. [PDF]
PLoS ONE, 2016 Epithelial-mesenchymal transition (EMT) is an evolutionarily conserved process during which cells lose epithelial characteristics and gain a migratory phenotype.
Pricila K Moly +4 more
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