Results 11 to 20 of about 10,608 (175)

Epiblast lumenogenesis is not a mammalian-specific trait [PDF]

Nature Communications
Epiblast lumenogenesis is a hallmark of mammalian embryogenesis, and crucial for the subsequent processes of anterior-posterior patterning and gastrulation.
Antonia Weberling, Natalia A. Shylo, Hannah Wilson, Melainia McClain, Richard Kupronis, Alex Muensch, Suzannah A. Williams, Florian Hollfelder, Paul A. Trainor   +8 more
doaj   +3 more sources

Molecular Regulation of Post-Hatching Embryo Development: Implications for Early Pregnancy Losses in Livestock Species. [PDF]

Reprod Domest Anim
ABSTRACT Pregnancy loss (PL) remains a major limitation to reproductive efficiency in livestock, with a substantial proportion originating during early embryo development, particularly between blastocyst hatching and implantation. This developmental window encompasses complex processes of lineage differentiation and morphogenesis. Accumulating evidence
Siegmund-Sabater A, Martínez de Los Reyes N, Flores-Borobia I, González-Brusi L, Galiano-Cogolludo B, Marigorta P, Bermejo-Álvarez P, Ramos-Ibeas P.   +7 more
europepmc   +2 more sources

Livestock Blastoids: In Vitro Blastocyst Models for Embryogenesis and Reproductive Technologies. [PDF]

Reprod Domest Anim
ABSTRACT Understanding early embryogenesis in livestock remains a persistent bottleneck in both reproductive biology and animal breeding. Work in domestic species has long been limited by restricted access to embryos, ethical considerations, and the complexity of peri‐implantation development, making mechanistic studies difficult.
Martinez-Serrano CA, Wu J.
europepmc   +2 more sources

Charting Morphotoxicity With Complementary Embryo Models. [PDF]

Adv Healthc Mater
Three human embryo models of the peri‐implantation stages are exposed to a library of compounds. The (toxic) effects of the compounds are analyzed through automated image analysis pipelines. By evaluating the differential responses of the embryo models, this study underscores the importance of testing complementary embryo models to achieve robust and ...
Luijkx DG, Balder PL, Verhagen RML, Shankar V, Jutten B, Samal P, Rademakers T, van Blitterswijk CA, Giselbrecht S, Vrij EJ.   +9 more
europepmc   +2 more sources

Beyond Binary: Cardiac Patterning as Probabilistic Fate Restriction. [PDF]

Bioessays
Are cardiac progenitors committed to fixed lineages, or do they carry probability distributions over heart regions in the epiblast that resolve during gastrulation? Reanalyzing mouse retrospective clonal data, we find no single lineage tree, instead 361 distinct restriction topologies, consistent with a probabilistic model where epiblast position set ...
Ivanovitch K.
europepmc   +2 more sources

The endo-lysosomal system drives lumen formation in a human epiblast model [PDF]

Nature Communications
Epiblast lumen formation is a critical step that occurs during human embryo implantation. It begins with the apicosome, an apical compartment partly derived from endocytosed material.
Anusha. Rengarajan, Sicong Wang, Chien-Wei Lin, Lauren E. Elberfeld, Jenna C. Wettstein, Amber E. Carleton, Nikola Sekulovski, Linnea E. Taniguchi, Bailey E. Schultz, Mara C. Duncan, Kenichiro Taniguchi   +10 more
doaj   +2 more sources

Suppressing Nodal Signaling Activity Predisposes Ectodermal Differentiation of Epiblast Stem Cells

Stem Cell Reports, 2018
Summary: The molecular mechanism underpinning the specification of the ectoderm, a transient germ-layer tissue, during mouse gastrulation was examined here in a stem cell-based model.
Guizhong Cui, Patrick P L Tam, Yingying Chen   +2 more
exaly   +3 more sources

Loss of the Otx2-Binding Site in the Nanog Promoter Affects the Integrity of Embryonic Stem Cell Subtypes and Specification of Inner Cell Mass-Derived Epiblast

Cell Reports, 2016
Mouse embryonic stem cells (ESCs) and the inner cell mass (ICM)-derived epiblast exhibit naive pluripotency. ESC-derived epiblast stem cells (EpiSCs) and the postimplantation epiblast exhibit primed pluripotency.
Marco Savarese, Giuseppe Petrosino, Vincenzo Nigro   +2 more
exaly   +3 more sources

Epigenetic blind spots - the role of DNA methylation dynamics in stem cell-based models of embryogenesis. [PDF]

FEBS Lett
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Canil S, Corrà A, Scapolatiello A, Qiu C, Amadei G.   +4 more
europepmc   +2 more sources

The number of primitive endoderm cells in the inner cell mass is regulated by platelet-derived growth factor signaling in porcine preimplantation embryos [PDF]

Animal Bioscience, 2023
Objective Discovering the mechanism of cell specification is important to manipulate cellular lineages. To obtain lineage-specific cell lines, the target lineage needs to be promoted, and counterpart lineages should be suppressed.
Jong-Nam Oh, Mingyun Lee, Gyung Cheol Choe, Dong-Kyung Lee, Kwang-Hwan Choi, Seung-Hun Kim, Jinsol Jeong, Chang-Kyu Lee   +7 more
doaj   +1 more source