Results 21 to 30 of about 24,553 (253)

Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation

Nature Cell Biology, 2022
WNT signalling has multiple roles. It maintains pluripotency of embryonic stem cells, assigns posterior identity in the epiblast and induces mesodermal tissue.
R. Blassberg, H. Patel, Thomas Watson, Mina Gouti, Vicki Metzis, M. Delás, J. Briscoe   +6 more
semanticscholar   +1 more source

Generation and characterization of stable pig pregastrulation epiblast stem cell lines

Cell Research, 2021
Pig epiblast-derived pluripotent stem cells are considered to have great potential and broad prospects for human therapeutic model development and livestock breeding.
Minglei Zhi, Jinying Zhang, Q. Tang, Dawei Yu, Shuai Gao, Dengfeng Gao, Pengliang Liu, Jianxiong Guo, T. Hai, Jie Gao, Suying Cao, Zimo Zhao, Chongyang Li, Xiao-gang Weng, M. He, Tianzhi Chen, Yingjie Wang, K. Long, Deling Jiao, Guanglei Li, Jiaman Zhang, Yan Liu, Yu Lin, D. Pang, Qianqian Zhu, Naixin Chen, Jingjing Huang, Xinze Chen, Yixuan Yao, Jing-Chan Yang, Zicong Xie, Xianya Huang, Mengxin Liu, Ran Zhang, Qiuyan Li, Yiliang Miao, Jianhui Tian, Xingxu Huang, Hongsheng Ouyang, Bofeng Liu, Wei Xie, Qi Zhou, Hongjiang Wei, Zhonghua Liu, Caihong Zheng, Mingzhou Li, Jianyong Han   +46 more
semanticscholar   +1 more source

Formative pluripotent stem cells show features of epiblast cells poised for gastrulation

Cell Research, 2021
The pluripotency of mammalian early and late epiblast could be recapitulated by naïve embryonic stem cells (ESCs) and primed epiblast stem cells (EpiSCs), respectively.
Xiaoxiao Wang, Yunlong Xiang, Yang Yu, Ran Wang, Yu Zhang, Qianhua Xu, Hao Sun, Zhen-Ao Zhao, Xiangxiang Jiang, Xiaoqing Wang, Xukun Lu, Dan-Dan Qin, Yujun Quan, Jiaqi Zhang, Ng Shyh‐Chang, Hongmei Wang, N. Jing, Wei Xie, Lei Li   +18 more
semanticscholar   +1 more source

Measurement of junctional tension in epithelial cells at the onset of primitive streak formation in the chick embryo via non-destructive optical manipulation [PDF]

, 2020
Directional cell intercalations of epithelial cells during gastrulation has in several organisms been shown to be associated with a planar cell polarity in the organisation of the actin-myosin cytoskeleton and is postulated to reflect directional tension
Antin, Avidan, Bachvarova, Bambardekar, Bertet, Blankenship, Campàs, Chapman, Chinthalapudi, Chuai, Clément, Collinet, Cui, Eyal-Giladi, Favre-Bulle, Fedorov, Fernandez-Gonzalez, Firmino, Gräper, Guillot, Guirao, Hamburger, Harris, Huisstede, Johansen, Lee, Montange, Neuman, Paré, Rauzi, Rauzi, Rozbicki, Sonal, Stern, Tolić-Nørrelykke, Vakaet, Voiculescu, Voiculescu, Volpe, Zallen   +39 more
core   +4 more sources

Epiblast inducers capture mouse trophectoderm stem cells in vitro and pattern blastoids for implantation in utero.

Cell Stem Cell, 2022
The embryo instructs the allocation of cell states to spatially regulate functions. In the blastocyst, patterning of trophoblast (TR) cells ensures successful implantation and placental development.
Jinwoo Seong, Javier Frias-Aldeguer, Viktoria Holzmann, Harunobu Kagawa, Giovanni Sestini, Heidar Heidari Khoei, Yvonne Scholte op Reimer, M. Kip, Saurabh J. Pradhan, Lucas Verwegen, J. Vivié, Linfeng Li, A. Alemany, J. Korving, F. Darmis, A. van Oudenaarden, D. ten Berge, N. Geijsen, N. Rivron   +18 more
semanticscholar   +1 more source

Rat epiblast-derived stem cells recapitulate the attributes of pre-gastrulation epiblast

Cell Reports Methods, 2023
Iwatsuki and colleagues have generated self-renewing pluripotent stem cells from the pre-gastrulation epiblast of the rat embryo and from other cellular sources: rat embryonic stem cells (rESCs) and epiblast-like cells derived from the rESCs. These rat epiblast-derived stem cells (rEpiSCs) display germ-line competence that is characteristic of mouse ...
V. Pragathi Masamsetti, Patrick P.L. Tam
openaire   +2 more sources

Rap1 controls epiblast morphogenesis in sync with the pluripotency states transition.

Developmental Cell, 2022
The complex architecture of the murine fetus originates from a simple ball of pluripotent epiblast cells, which initiate morphogenesis upon implantation.
Y. S. Kim, Rui Fan, Sanne C. Lith, A. Dicke, H. Drexler, L. Kremer, Nannette Kuempel-Rink, L. Hekking, M. Stehling, Ivan Bedzhov   +9 more
semanticscholar   +1 more source

Human naive epiblast cells possess unrestricted lineage potential

bioRxiv, 2020
Classical mouse embryology has established a paradigm of early development driven by sequential lineage bifurcations. Accordingly, mouse embryonic stem cells derived from early epiblast have lost the potency to produce extraembryonic trophectoderm.
G. Guo, G. Stirparo, S. Strawbridge, D. Spindlow, Jian Yang, James Clarke, Anish Dattani, A. Yanagida, M. Li, Samuel Myers, Buse Nurten Özel, J. Nichols, Austin G Smith   +12 more
semanticscholar   +1 more source

Deciphering epiblast lumenogenesis reveals proamniotic cavity control of embryo growth and patterning

Science Advances, 2021
Dissecting the mechanisms of lumen formation in the epiblast revealed that the proamniotic cavity acts as a central signaling hub. During the peri-implantation stages, the mouse embryo radically changes its appearance, transforming from a hollow-shaped ...
Y. S. Kim, Rui Fan, L. Kremer, Nannette Kuempel-Rink, K. Mildner, D. Zeuschner, L. Hekking, M. Stehling, Ivan Bedzhov   +8 more
semanticscholar   +1 more source

Microgel culture and spatial identity mapping elucidate the signalling requirements for primate epiblast and amnion formation

Development, 2022
The early specification and rapid growth of extraembryonic membranes are distinctive hallmarks of primate embryogenesis. These complex tasks are resolved through an intricate combination of signals controlling the induction of extraembryonic lineages and,
Clara Munger, Timo N. Kohler, Erin Slatery, Anna L. Ellermann, Sophie Bergmann, Christopher A. Penfold, Ioakeim Ampartzidis, Yutong Chen, F. Hollfelder, Thorsten E. Boroviak   +9 more
semanticscholar   +1 more source