Results 91 to 100 of about 24,553 (253)

When proteases reshape barriers: Basement membrane remodelling in development, wound healing and tumour progression

The FEBS Journal, EarlyView.
Basement membrane (BM) homeostasis relies on a balance between integrity, controlled remodelling and pathological degradation. Increased protease expression beneath the BM, along with reduced levels of endogenous protease inhibitors, drives the transition from a continuous, protective barrier to a discontinuous interface.
Clara Legendre, Guila Dayan, Patricia Rousselle   +2 more
wiley   +1 more source

Specific epiblast loss and hypoblast impairment in cattle embryos sensitized to survival signalling by ubiquitous overexpression of the proapoptotic gene BAD.

PLoS ONE, 2014
Early embryonic lethality is common, particularly in dairy cattle. We made cattle embryos more sensitive to environmental stressors by raising the threshold of embryo survival signaling required to overcome the deleterious effects of overexpressing the ...
Jessica van Leeuwen, Debra K Berg, Craig S Smith, David N Wells, Peter L Pfeffer   +4 more
doaj   +1 more source

The human amniotic epithelium confers a bias to differentiate toward the neuroectoderm lineage in human embryonic stem cells

eLife, 2022
Human embryonic stem cells (hESCs) derive from the epiblast and have pluripotent potential. To maintain the conventional conditions of the pluripotent potential in an undifferentiated state, inactivated mouse embryonic fibroblast (iMEF) is used as a ...
Daniela Ávila-González, Wendy Portillo, Carla P Barragán-Álvarez, Georgina Hernandez-Montes, Eliezer Flores-Garza, Anayansi Molina-Hernández, Néstor Emmanuel Díaz-Martínez, Néstor F Díaz   +7 more
doaj   +1 more source

Dissecting the dynamics of signaling events in the BMP, WNT, and NODAL cascade during self-organized fate patterning in human gastruloids. [PDF]

, 2019
During gastrulation, the pluripotent epiblast self-organizes into the 3 germ layers-endoderm, mesoderm and ectoderm, which eventually form the entire embryo.
Chhabra, Sapna, Goh, Ryan, Kong, Xiangyu, Liu, Lizhong, Warmflash, Aryeh   +4 more
core   +1 more source

Immunophenotypic assessment of pure embryonal carcinoma and yolk sac tumour suggests that reprogramming to non‐seminoma occurs outside the spermatogonial niche

Histopathology, EarlyView.
Immunohistochemical analysis of transcription factors in GCNIS associated with pure EC and YST suggests that reprogramming to non‐seminoma occurs outside the spermatogonial niche. In these tumors, reprogramming may occur immediately upon invasion of the stroma or within seminiferous tubules but outside the spermatogonial niche (i.e., in intratubular ...
Daisy Maharjan, Květoslava Michalová, Joao Lobo, Jennifer Gordetsky, Fiona MacLean, Ankur R Sangoi, Daniel Berney, Chia‐Sui Kao, Costantino Ricci, Adeboye O Osunkoya, Maria Rosaria Raspollini, Geert JLH van Leenders, Muhammad T Idrees, Lee Ann Baldridge, Thomas M Ulbright, Andres M Acosta   +15 more
wiley   +1 more source

A novel, PCP‐dependent tissue organising principle coordinating morphogenesis between embryonic skin epidermal layers

Journal of Anatomy, EarlyView.
‘Outside‐in’ expression of Fz6 across multiple layers of mouse embryo epidermis is connected to Fz6 asymmetry in the basal layer plane. Fz6 loss‐of‐function correlated with failure to: coordinate axial bias of cell long axis orientation across epidermal layers, switch axial cell long axis orientation during suprabasal layer development and establish ...
C. J. Formstone
wiley   +1 more source

NANOG is required to form the epiblast and maintain pluripotency in the bovine embryo

Molecular Reproduction and Development, 2019
During preimplantation development, the embryo undergoes two consecutive lineages specifications. The first cell fate decision determines which cells give rise to the trophectoderm (TE) and the inner cell mass (ICM).
M. S. Ortega, A. M. Kelleher, Eleanor O'Neil, J. Benne, R. Cecil, T. E. Spencer   +5 more
semanticscholar   +1 more source

Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells [PDF]

Development, 2012
Somatic development initiates from the epiblast in post-implantation mammalian embryos. Recent establishment of epiblast stem cell (EpiSC) lines has opened up new avenues of investigation of the mechanisms that regulate the epiblast state and initiate lineage-specific somatic development.
Makiko, Iwafuchi-Doi, Kazunari, Matsuda, Kazuhiro, Murakami, Hitoshi, Niwa, Paul J, Tesar, Jun, Aruga, Isao, Matsuo, Hisato, Kondoh   +7 more
openaire   +2 more sources

The Origin of Endoderm: Transmission Electron Microscopic Point of View

Siriraj Medical Journal, 2020
Objective: To show the transmission electron microscopic (TEM) evidence to confirm that the endoderm originates from the epiblast of the primitive streak or from other sources.
Jantima Roongruangchai, Kosol Roongruangchai, Ratirat Kolaka   +2 more
doaj  

Morphological and Gene Expression Changes in Cattle Embryos from Hatched Blastocyst to Early Gastrulation Stages after Transfer of In Vitro Produced Embryos. [PDF]

PLoS ONE, 2015
A detailed morphological staging system for cattle embryos at stages following blastocyst hatching and preceding gastrulation is presented here together with spatiotemporal mapping of gene expression for BMP4, BRACHYURY, CERBERUS1 (CER1), CRIPTO ...
Jessica van Leeuwen, Debra K Berg, Peter L Pfeffer   +2 more
doaj   +1 more source