Results 121 to 130 of about 24,147 (238)

The epigenetic modifier Fam208a is required to maintain epiblast cell fitness

Scientific Reports, 2017
Gastrulation initiates with the formation of the primitive streak, during which, cells of the epiblast delaminate to form the mesoderm and definitive endoderm.
Shohag Bhargava, Brian Cox, Christiana Polydorou, Veronika Gresakova, Vladimir Korinek, Hynek Strnad, Radislav Sedlacek, Trevor Allan Epp, Kallayanee Chawengsaksophak   +8 more
doaj   +1 more source

PDGFRα+ Cells in Embryonic Stem Cell Cultures Represent the In Vitro Equivalent of the Pre-implantation Primitive Endoderm Precursors

Stem Cell Reports, 2017
In early mouse pre-implantation development, primitive endoderm (PrE) precursors are platelet-derived growth factor receptor alpha (PDGFRα) positive. Here, we demonstrated that cultured mouse embryonic stem cells (mESCs) express PDGFRα heterogeneously ...
Antonio Lo Nigro, Anchel de Jaime-Soguero, Rita Khoueiry, Dong Seong Cho, Giorgia Maria Ferlazzo, Ilaria Perini, Vanesa Abon Escalona, Xabier Lopez Aranguren, Susana M. Chuva de Sousa Lopes, Kian Peng Koh, Pier Giulio Conaldi, Wei-Shou Hu, An Zwijsen, Frederic Lluis, Catherine M. Verfaillie   +14 more
doaj   +1 more source

Essential role for PDGF signaling in ophthalmic trigeminal placode induction [PDF]

, 2008
Much of the peripheral nervous system of the head is derived from ectodermal thickenings, called placodes, that delaminate or invaginate to form cranial ganglia and sense organs.
Bronner-Fraser, Marianne, McCabe, Kathryn L.   +1 more
core   +1 more source

Single-Cell RNA-Seq Reveals Cellular Heterogeneity of Pluripotency Transition and X Chromosome Dynamics during Early Mouse Development

Cell Reports, 2019
Summary: Following implantation, the epiblast (EPI) cells transit from the naive to primed pluripotency, accompanied by dynamic changes in X chromosome activity in females. To investigate the molecular attributes of this process, we performed single-cell
Shangli Cheng, Yu Pei, Liqun He, Guangdun Peng, Björn Reinius, Patrick P.L. Tam, Naihe Jing, Qiaolin Deng   +7 more
doaj   +1 more source

ZMYM2 inhibits NANOG-mediated reprogramming [version 1; peer review: 2 approved]

Wellcome Open Research, 2019
Background: NANOG is a homeodomain-containing transcription factor which forms one of the hubs in the pluripotency network and plays a key role in the reprogramming of somatic cells and epiblast stem cells to naïve pluripotency.
Moyra Lawrence, Thorold W. Theunissen, Patrick Lombard, David J. Adams, José C. R. Silva   +4 more
doaj   +1 more source

Cripto is essential to capture mouse epiblast stem cell and human embryonic stem cell pluripotency

Nature Communications, 2016
Known molecular determinants of developmental plasticity are mainly transcription factors, while the extrinsic regulation of this process has been largely unexplored. Here we identify Cripto as one of the earliest epiblast markers and a key extracellular
Alessandro Fiorenzano, Emilia Pascale, Cristina d’Aniello, D. Acampora, Cécilia Bassalert, Francesco Russo, Gennaro Andolfi, M. Biffoni, Federica Francescangeli, A. Zeuner, C. Angelini, Claire Chazaud, E. Patriarca, A. Fico, G. Minchiotti   +14 more
semanticscholar   +1 more source

Pluripotency Potential of Embryonic Stem Cell-Like Cells Derived from Mouse Testis

Cell Journal, 2019
Objective: During the cultivation of spermatogonial stem cells (SSCs) and their conversion into embryonic stem-like (ES-like) cells, transitional ES-like colonies and epiblast-like cells were observable.
Hossein Azizi, Behruz Asgari, Thomas Skutella   +2 more
doaj   +1 more source

Epiblast-Like Stem Cells Established by Wnt/β-Catenin Signaling Manifest Distinct Features of Formative Pluripotency

, 2022
Qing Luo, Han‐Pin Pui, Jiayu Chen, Leqian Yu, Paulo R. Jannig, Yu Pei, Linxuan Zhao, Sophie Petropoulos, Xinqi Chen, Jorge L. Ruas, Jun Wu, Qiaolin Deng   +11 more
openalex   +1 more source

Inappropriate cadherin switching in the mouse epiblast compromises proper signaling between the epiblast and the extraembryonic ectoderm during gastrulation [PDF]

, 2016
M. Felicia Basilicata, Marcus Frank, Davor Solter, Thomas Brabletz, Marc P. Stemmler   +4 more
openalex   +1 more source

Zeb2 Regulates Cell Fate at the Exit from Epiblast State in Mouse Embryonic Stem Cells

Stem Cells, 2016
In human embryonic stem cells (ESCs) the transcription factor Zeb2 regulates neuroectoderm versus mesendoderm formation, but it is unclear how Zeb2 affects the global transcriptional regulatory network in these cell‐fate decisions.
Agata Stryjewska, Ruben Dries, T. Pieters, Griet Verstappen, A. Conidi, Kathleen Coddens, Annick Francis, L. Umans, W. V. van Ijcken, G. Berx, L. V. van Grunsven, F. Grosveld, S. Goossens, J. Haigh, D. Huylebroeck   +14 more
semanticscholar   +1 more source