Results 141 to 150 of about 24,553 (253)

ZMYM2 inhibits NANOG-mediated reprogramming [version 1; peer review: 2 approved]

Wellcome Open Research, 2019
Background: NANOG is a homeodomain-containing transcription factor which forms one of the hubs in the pluripotency network and plays a key role in the reprogramming of somatic cells and epiblast stem cells to naïve pluripotency.
Moyra Lawrence, Thorold W. Theunissen, Patrick Lombard, David J. Adams, José C. R. Silva   +4 more
doaj   +1 more source

The ability of inner cell mass cells to self-renew as embryonic stem cells is acquired upon epiblast specification

Nature Cell Biology, 2014
The precise relationship of embryonic stem cells (ESCs) to cells in the mouse embryo remains controversial. We present transcriptional and functional data to identify the embryonic counterpart of ESCs.
Thorsten E. Boroviak, R. Loos, Paul Bertone, Austin G Smith, J. Nichols   +4 more
semanticscholar   +1 more source

p53-mediated regulation of epiblast cell numbers predicts reactivation during mouse embryonic diapause

Cell Reports
Summary: Embryonic diapause is a temporary suspension of proliferation in mammalian pre-implantation embryos, allowing for reactivation later. Cells in mouse diapause embryos enter the G0 phase within 7 days of diapause initiation.
Megumi Murata, Akihito Harada, Haruka Hirose, Hinako Maeda, Teppei Shimamura, Yasuyuki Ohkawa, Tatsuya Takemoto, Katsuyoshi Takaoka   +7 more
doaj   +1 more source

YAP1 and QSER1 are key modulators of embryonic signaling pathways in the mammalian epiblast

EMBO Reports
YAP1 signaling is essential for development but its specific roles in early embryogenesis remain poorly understood. To shed light on this, we analyze YAP1’s role in regulating the pluripotency of the mammalian epiblast, using scRNAseq approaches ...
Elizabeth Abraham, Thomas Roule, Aidan Douglas, Emily Megill, Olivia M Pericak, Jordan E Howe, Carmen Choya-Foces, Joanne F Garbincius, Henry M Cohen, Paula Roig-Flórez, Mikel Zubillaga, Mark D Andrake, Seonhee Kim, John W Elrod, Naiara Akizu, Conchi Estaras   +15 more
doaj   +1 more source

A human epiblast model reveals dynamic TGFβ-mediated control of epithelial identity during mammalian epiblast development

Nature Cell Biology
Pluripotency, the ability to generate all body cell types, emerges in a disorganized embryonic cell mass. After implantation, these cells form a columnar epithelium and initiate lumenogenesis. During gastrulation, some undergo epithelial-to-mesenchymal transition to form the primitive streak (PS).
Irene Zorzan, Elena Carbognin, Andrea Lauria, Valentina Proserpio, Davide Benvegnù, Federica Bertelli, Susana De Juambelz Urías, Caterina Dalrio, Giorgia Panebianco, Rebecca Scarfò, Eleonora Pensabene, Mattia Arboit, Irene Paolucci, Andrea Drusin, Dario Bizzotto, Monika Sledziowska, Paola Braghetta, Andrea Ditadi, Gianluca Amadei, Salvatore Oliviero, Graziano Martello   +20 more
openaire   +2 more sources

Primitive to visceral endoderm maturation is essential for mouse epiblast survival beyond implantation

iScience
Summary: The implantation of the mouse blastocyst initiates a complex sequence of tissue remodeling and cell differentiation events required for morphogenesis, during which the extraembryonic primitive endoderm transitions into the visceral endoderm ...
Antonia Weberling, Dylan Siriwardena, Christopher Penfold, Neophytos Christodoulou, Thorsten E. Boroviak, Magdalena Zernicka-Goetz   +5 more
doaj   +1 more source

The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells.

Cell, 2003
Kaoru Mitsui, Yoshimi Tokuzawa, H. Itoh, K. Segawa, Mirei Murakami, Kazutoshi Takahashi, Masayoshi Maruyama, M. Maeda, S. Yamanaka   +8 more
semanticscholar   +1 more source

Non-apical mitoses contribute to cell delamination during mouse gastrulation

Nature Communications
During the epithelial-mesenchymal transition driving mouse embryo gastrulation, cells divide more frequently at the primitive streak, and half of those divisions happen away from the apical pole.
Evangéline Despin-Guitard, Viviane S. Rosa, Steffen Plunder, Navrita Mathiah, Kristof Van Schoor, Eliana Nehme, Sara Merino-Aceituno, Joaquim Egea, Marta N. Shahbazi, Eric Theveneau, Isabelle Migeotte   +10 more
doaj   +1 more source

Modeling mammalian gastrulation with embryonic stem cells

, 2017
Understanding cell fate patterning and morphogenesis in the mammalian embryo remains a formidable challenge. Recently, in vivo models based on embryonic stem cells (ESCs) have emerged as complementary methods to quantitatively dissect the physical and ...
Amita, Arnold, Azioune, Bauwens, Bedzhov, Ben-Haim, Bernardo, Blin, Bolouri, Chambers, Coucouvanis, Dunn, Engler, Etoc, Farin, Gjorevski, Green, Gurdon, Harrison, Heemskerk, Heemskerk, Horii, Lee, Lei, Li, Lippmann, Loh, Meinhardt, Meinhardt, Mendjan, Migeotte, Müller, Nakamura, Nallet-Staub, Nemashkalo, Nemashkalo, Nowotschin, Pagliuca, Peerani, Perea-Gomez, Przybyla, Qin, Ranga, Rosowski, Saka, Sasai, Schohl, Shao, Shao, Simunovic, Sorre, Sun, Tang, ten Berge, Teo, Tewary, Théry, Turing, Turner, Turner, van den Brink, Warmflash, Wilson, Xu, Yang, Yu   +65 more
core   +1 more source

Multicellular rosette formation during cell ingression in the avian primitive streak [PDF]

, 2007
Akiyama, Bertocchini, Blankenship, Chapman, Chuai, Ciruna, Cui, Etienne-Manneville, Graeper, Gundersen, Hamburger, Kelly, Kroboth, Lansbergen, Lawson, Mikawa, Mimori-Kiyosue, Mogensen, Mogenson, Stern, Sun, Vakaet, Watanabe, Watanabe, Wittmann, Yang   +25 more
core   +1 more source