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Embryonic development: Tracing the origin of epiblast cells
Current BiologyThe epiblast is the source of all the cells of our bodies and of the pluripotent embryonic stem cells. Novel work using fluorescent reporter-based cell tracking supports a stochastic mechanism for epiblast differentiation and reveals SOX2 as the most obvious marker.
Violaine, Paulus, Claire, Chazaud
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Isolation and Maintenance of Mouse Epiblast Stem Cells
2010Epiblast stem cells (EpiSCs) are isolated from the postimplantation mouse embryo just after implantation but prior to gastrulation. EpiSCs are pluripotent and provide a tractable, in vitro system to study the processes that function during gastrulation to transition pluripotent cells to their differentiated derivatives.
Josh G, Chenoweth, Paul J, Tesar
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Ultrastructure of Auxin-Induced Tumors of the Coleorhiza-Epiblast of Wheat
American Journal of Botany, 1975When wheat is germinated in high concentrations of certain auxins, the coleorhiza‐epiblast grows in an excessive and disorganized manner and resembles a callus. Wheat was germinated in 10−3 M indoleacetic acid or in water. There was greater net synthesis of DNA, RNA, and protein in the tumor tissue than in control tissue.
Patricia L, Walne +2 more
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Ultrastructural and immunohistochemical characterization of the bovine epiblast.
Biology of reproduction, 2005The epiblast represents the final embryonic founder cell population with the potential for giving rise to all cell types of the adult body. The pluripotency of the epiblast is lost during the process of gastrulation. Large animal species have a lack of specific markers for pluripotency.
Vejlsted, Morten +5 more
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NOGGIN Transport in a Model Human Epiblast
2021A thesis presented to the faculty of The Rockefeller University in partial fulfillment of the requirements for the degree of Doctor of ...
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Nature Cell Biology
Pluripotency, the ability to generate all body cell types, emerges in a disorganized embryonic cell mass. After implantation, these cells form a columnar epithelium and initiate lumenogenesis. During gastrulation, some undergo epithelial-to-mesenchymal transition to form the primitive streak (PS).
Irene Zorzan +20 more
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Pluripotency, the ability to generate all body cell types, emerges in a disorganized embryonic cell mass. After implantation, these cells form a columnar epithelium and initiate lumenogenesis. During gastrulation, some undergo epithelial-to-mesenchymal transition to form the primitive streak (PS).
Irene Zorzan +20 more
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The Epiblast and Pluripotent Stem Cell Lines
All somatic cells develop from the epiblast, which occupies the upper layer of two-layered embryos and in most mammals is formed after the implantation stage but before gastrulation initiates. Once the epiblast is established, the epiblast cells begin to develop into various somatic cells via large-scale cell reorganization, namely, gastrulation ...openaire +2 more sources
Control of epiblast cell fate by mechanical cues
Summary In amniotes, embryonic tissues originate from multipotent epiblast cells, arranged in a mosaic of presumptive territories. How these domains fated to specific lineages become segregated during body formation remains poorly understood.Charlène Guillot +3 more
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Human naive epiblast cells possess unrestricted lineage potential
Cell Stem Cell, 2021Austin Smith +2 more
exaly
Human epiblast lumenogenesis: From a cell aggregate to a lumenal cyst
Seminars in Cell and Developmental Biology, 2022Mara C Duncan +2 more
exaly