Results 131 to 140 of about 24,147 (238)

Totipotent Embryonic Stem Cells Arise in Ground-State Culture Conditions

Cell Reports, 2013
Embryonic stem cells (ESCs) are derived from mammalian embryos during the transition from totipotency, when individual blastomeres can make all lineages, to pluripotency, when they are competent to make only embryonic lineages.
Sophie M. Morgani, Maurice A. Canham, Jennifer Nichols, Alexei A. Sharov, Rosa Portero Migueles, Minoru S.H. Ko, Joshua M. Brickman   +6 more
doaj   +1 more source

ICM conversion to epiblast by FGF/ERK inhibition is limited in time and requires transcription and protein degradation

Scientific Reports, 2017
Inner cell Mass (ICM) specification into epiblast (Epi) and primitive endoderm (PrE) is an asynchronous and progressive process taking place between E3.0 to E3.75 under the control of the Fibroblast Growth Factor (FGF)/Extracellular signal-Regulated ...
Sylvain Bessonnard, S. Coqueran, S. Vandormael-Pournin, A. Dufour, Jérôme Artus, M. Cohen-Tannoudji   +5 more
semanticscholar   +1 more source

p53-mediated regulation of epiblast cell numbers predicts reactivation during mouse embryonic diapause

Cell Reports
Summary: Embryonic diapause is a temporary suspension of proliferation in mammalian pre-implantation embryos, allowing for reactivation later. Cells in mouse diapause embryos enter the G0 phase within 7 days of diapause initiation.
Megumi Murata, Akihito Harada, Haruka Hirose, Hinako Maeda, Teppei Shimamura, Yasuyuki Ohkawa, Tatsuya Takemoto, Katsuyoshi Takaoka   +7 more
doaj   +1 more source

Zfp281 is essential for mouse epiblast maturation through transcriptional and epigenetic control of Nodal signaling

eLife, 2017
Pluripotency is defined by a cell's potential to differentiate into any somatic cell type. How pluripotency is transited during embryo implantation, followed by cell lineage specification and establishment of the basic body plan, is poorly understood ...
Xin Huang, Sophie Balmer, Fan Yang, Miguel Fidalgo, Dan Li, D. Guallar, A. Hadjantonakis, Jianlong Wang   +7 more
semanticscholar   +1 more source

A Method to Identify and Isolate Pluripotent Human Stem Cells and Mouse Epiblast Stem Cells Using Lipid Body-Associated Retinyl Ester Fluorescence [PDF]

, 2014
Thangaselvam Muthusamy, Odity Mukherjee, Radhika Menon, Megha Prakash Bangalore, Mitradas M. Panicker   +4 more
openalex   +1 more source

Primitive to visceral endoderm maturation is essential for mouse epiblast survival beyond implantation

iScience
Summary: The implantation of the mouse blastocyst initiates a complex sequence of tissue remodeling and cell differentiation events required for morphogenesis, during which the extraembryonic primitive endoderm transitions into the visceral endoderm ...
Antonia Weberling, Dylan Siriwardena, Christopher Penfold, Neophytos Christodoulou, Thorsten E. Boroviak, Magdalena Zernicka-Goetz   +5 more
doaj   +1 more source

Nodal signal is required for morphogenetic movements of epiblast layer in the pre‐streak chick blastoderm [PDF]

, 2011
Nariaki Yanagawa, Masahide Sakabe, Hirokazu Sakata, Toshiyuki Yamagishi, Yuji Nakajima   +4 more
openalex   +1 more source

Non-apical mitoses contribute to cell delamination during mouse gastrulation

Nature Communications
During the epithelial-mesenchymal transition driving mouse embryo gastrulation, cells divide more frequently at the primitive streak, and half of those divisions happen away from the apical pole.
Evangéline Despin-Guitard, Viviane S. Rosa, Steffen Plunder, Navrita Mathiah, Kristof Van Schoor, Eliana Nehme, Sara Merino-Aceituno, Joaquim Egea, Marta N. Shahbazi, Eric Theveneau, Isabelle Migeotte   +10 more
doaj   +1 more source

Embryonic Cul4b is important for epiblast growth and location of primitive streak layer cells.

PLoS ONE, 2019
Cul4b-null (Cul4bΔ/Y) mice undergo growth arrest and degeneration during the early embryonic stages and die at E9.5. The pathogenic causes of this lethality remain incompletely characterized.
Chun-Yu Chen, I-Shing Yu, Chen-Hsueh Pai, Chien-Yu Lin, Shu-Rung Lin, You-Tzung Chen, Shu-Wha Lin   +6 more
doaj   +1 more source

MLL1 Inhibition Reprograms Epiblast Stem Cells to Naive Pluripotency [PDF]

, 2016
Hui Zhang, Srimonta Gayen, Jie Xiong, Bo Zhou, Avinash Kumar Shanmugam, Yuqing Sun, Hacer Karataş, Liu Liu, Rajesh C. Rao, Shaomeng Wang, Alexey I. Nesvizhskii, Sundeep Kalantry, Yali Dou   +12 more
openalex   +1 more source