Induction of primordial germ cells from murine epiblasts by synergistic action of BMP4 and BMP8B signaling pathways [PDF]
Ying Ying, Xiaoxia Qi, Guang-Quan Zhao
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Embryonic Cul4b is important for epiblast growth and location of primitive streak layer cells.
Cul4b-null (Cul4bΔ/Y) mice undergo growth arrest and degeneration during the early embryonic stages and die at E9.5. The pathogenic causes of this lethality remain incompletely characterized.
Chun-Yu Chen+6 more
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Induction of Primordial Germ Cells from Pluripotent Epiblast [PDF]
Ying Ying, Xiaoxia Qi, Guang-Quan Zhao
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Challenges and possible clinical applications of human embryonic stem cell research [PDF]
Human embryonic stem cells (hESC) are harvested from the inner cell mass of the pre-implantation embryo and possess several unique characteristics. First, they are self-renewing, meaning they can grow indefinitely in an appropriate culture environment ...
De Sutter, Petra+3 more
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Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation [PDF]
Takao Sakai+9 more
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Primitive neural stem cells from the mammalian epiblast differentiate to definitive neural stem cells under the control of Notch signaling [PDF]
Seiji Hitoshi+7 more
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Orphan Nuclear Receptor LRH-1 Is Required To Maintain Oct4 Expression at the Epiblast Stage of Embryonic Development [PDF]
Peili Gu+12 more
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Trophectoderm mechanics direct epiblast shape upon embryo implantation
Antonia Weberling, M. Zernicka-Goetz
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The proper functioning of multicellular organisms requires the robust establishment of precise proportions between distinct cell-types. This developmental differentiation process typically involves intracellular regulatory and stochastic mechanisms to ...
Kaneko, Kunihiko, Pfeuty, Benjamin
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