Results 221 to 230 of about 1,962,623 (304)

NLSS3 Impairs SHM1 Autophagic Degradation to Regulate Leaf Morphology and Salt Tolerance in Rice

Advanced Science, EarlyView.
In rice, NLSS3 binds and shields SHM1 from autophagic degradation to maintain serine homeostasis. The A132P mutation in nlss3 disrupts this, triggering SHM1 loss, metabolic dysfunction, K+ imbalance, and impaired ROS scavenging, which collectively drive narrow leaves and salt sensitivity.
Xiong Liu, Yulu Yang, Zhiqi Hao, Jing Xu, Huibo Zhao, Qiang Zhang, Deyong Ren, Xia Li, Guojun Dong, Lan Shen, Li Zhu, Jiang Hu, Zhenyu Gao, Qing Li, Qian Qian, Guangheng Zhang   +15 more
wiley   +1 more source

Evaluating Tumor Burden as a Predictive Biomarker for Epidermal Growth Factor Receptor Targeted Kinase Inhibitor Therapy in Advanced Non-Small Cell Lung Cancer. [PDF]

JCO Precis Oncol
Terashima R, Fan J, Gunturkun F, Nieda G, Fan X, Rodriguez EM, Tan AX, Thottunkal S, Shaw M, Su CC, Khan A, Ding VY, Luo I, Satoyoshi M, Bhat A, Gu B, Henry SM, Ellis-Caleo TJ, Odden M, Kurian AW, Neal JW, Wakelee HA, Wu JT, Han SS.   +23 more
europepmc   +1 more source

Bilateral SERS‐Microneedle Patch for Co‐Diagnosis of Diabetes Mellitus and Tuberculosis Comorbidity

Advanced Science, EarlyView.
Our study introduced a U@mP@Au‐mediated bilateral SERS‐microneedle patch for analyzing glucose levels from ISF and sensitively detecting TB biomarkers from sputum, respectively. This integrated dual‐analyte detecting platform can be used for co‐diagnosis of diabetes mellitus (DM) and tuberculosis (TB) comorbidity, which was demonstrated in ex vivo ...
Xueqin Huang, Lingzhi Chen, Jing Xu, Jiaqi Yu, Shanze Chen, Huaihong Cai, Yanguang Cong, Pinghua Sun, Jiang Pi, Lang Rao, Jierong Chen, Junxia Zheng, Haibo Zhou   +12 more
wiley   +1 more source

Folliculitis Decalvans Due to Epidermal Growth Factor Inhibitor

Dermatology Practical & Conceptual
Aurora Maria Alessandrini, Alice Nadia Rossi, Emi Dika   +2 more
doaj   +1 more source

The amphiregulin- epidermal growth factor receptor axis as a therapeutic target in sepsis. [PDF]

Front Immunol
Walsh R, Snow TAC, Martinez AZ, Brealey D, Singer M, Das A, Arulkumaran N, University College London Hospitals Critical Care Research Team.   +7 more
europepmc   +1 more source

Multi‐Axis Stretchable Zippers for Personalized Wound Healing

Advanced Science, EarlyView.
Multi‐axis stretchable zippers can adapt to complex wound morphologies and enable personalized wound treatment through programmable contraction. This morphological matching strategy helps accelerate wound closure, improve blood perfusion, promote epithelial regeneration, and enhance collagen remodeling, pioneering new directions for personalized and ...
Siyuan Cai, Guang Yao, Zijian Chen, Shiqi Zhou, Peisi Li, Liheng Lin, Huake Yang, Ziyi Zhou, Linbo Jin, Xingyi Gan, Chenzheng Zhou, Zhen Cai, Taisong Pan, Min Gao, Dongli Fan, Yuan Lin, Yiming Zhang   +16 more
wiley   +1 more source

Multi-omics profiling reveals epidermal growth factor as a potential biomarker and therapeutic target in lupus nephritis and ANCA-associated vasculitis with rapidly progressive glomerulonephritis. [PDF]

PLoS One
Xu M, Cheng Q, Xie Y, Chen X, Zhu L, Su W, Du Y, Wu H, Lu K.   +8 more
europepmc   +1 more source

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source

Radiation therapy plus osimertinib <i>vs</i> osimertinib alone in epidermal growth factor receptor mutated non-small cell lung cancer: A systematic review. [PDF]

World J Methodol
Javed M, Fatima M, Hassan MB, Kumar S, Pawan R, Singh V, Kumar K, Amir R, Karim A, Jawed I, Alam F, Kumar D, Rai R, Tilokani H, Rizvi SAFA.   +14 more
europepmc   +1 more source

A Non‐Canonical Core Transcriptional Regulatory Circuit Orchestrates Chromatin Reprogramming to Drive Osimertinib Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
A non‐canonical core transcriptional regulatory circuit, composed of ID3, SMAD3, and NR2F2, drives Osimertinib resistance in non‐small cell lung cancer through super‐enhancer‐mediated activation of EPAS1, which couples neuroendocrine differentiation with ferroptosis evasion.
Aochu Liu, Zhenguo Liu, Lizhen Jiang, Andong Huang, Xinqing Lin, Xinyue Li, Bingyuan Liu, Shiwen Hu, Qiang Pan, Junjun Huang, Liyuan Yin, Liling Jiang, Wei Yi, Wenjun Mao, Yueyuan Zheng, Xianping Shi   +15 more
wiley   +1 more source