Results 71 to 80 of about 5,134,709 (287)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
iScience, 2018 Summary: Epidermal homeostasis requires balanced and coordinated adult stem cell renewal and differentiation. These processes are controlled by both extracellular signaling and by cell intrinsic transcription regulatory networks, yet how these control ...
Roderick A.P.M. van Eijl +4 more
doaj +1 more source
"Studies on the cardiomyocytic potential of dermal stem cells” [PDF]
, 2008 In Europe, diseases of the heart and circulatory system are the main cause of death; 48% of all deaths are from coronary heart disease, accounting for over 4.30 million deaths each year (European cardiovascular disease statistics 2008). Identifying stem
Cormack, Suzanne Marie
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Stem Cells of Epidermis: A Critical Introduction [PDF]
Journal of Cell and Molecular Research, 2013 Stem cells are the cells having some distinguishing characteristics like longevity, high capacity of self-renewal and differentiation, quiescence and highly error-free proliferation. Almost all stem cells have the potential of lineage reprogramming, i.e.
Muhammad Irfan-Maqsood
doaj +1 more source
Epidermal stem cell diversity and quiescence
EMBO Molecular Medicine, 2009 Mammalian epidermis is maintained by self-renewal of stem cells and terminal differentiation of their progeny. New data reveal a diversity amongst stem cells that was previously unrecognized. Different stem cell populations have different locations and differ in whether they are quiescent or actively cycling.
Watt, Fiona, Jensen, Kim B.
openaire +3 more sources
Comparative Analysis of the Frequency and Distribution of Stem and Progenitor Cells in the Adult Mouse Brain [PDF]
cells (NSCs) and progenitor cells, but it cannot discriminate between these two populations. Given two assays have purported to overcome this shortfall, we performed a comparative analysis of the distribution and frequency of NSCs and progenitor ...
Golmohammadi, Mohammed G. +17 more
core +1 more source
Long-term expansion and differentiation of adult murine epidermal stem cells in 3D organoid cultures [PDF]
, 2019 Mammalian epidermal stem cells maintain homeostasis of the skin epidermis and contribute to its regeneration throughout adult life. While 2D mouse epidermal stem cell cultures have been established decades ago, a long-term, feeder cell- and serum-free ...
Wiener, Dominique J. +12 more
core +3 more sources
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Multipotent nestin-positive stem cells reside in the stroma of human eccrine and apocrine sweat glands and can be propagated robustly in vitro. [PDF]
PLoS ONE, 2013 Human skin harbours multiple different stem cell populations. In contrast to the relatively well-characterized niches of epidermal and hair follicle stem cells, the localization and niches of stem cells in other human skin compartments are as yet ...
Sabine Nagel +8 more
doaj +1 more source