Results 1 to 10 of about 5,980,424 (294)

Antioxidants as an Epidermal Stem Cell Activator [PDF]

Antioxidants, 2020
Antioxidants may modulate the microenvironment of epidermal stem cells by reducing the production of reactive oxygen species or by regulating the expression of extracellular matrix protein. The extracellular membrane is an important component of the stem
Soon-Hyo Kwon, Kyoung-Chan Park
doaj   +6 more sources

Both Wnt signaling and epidermal stem cell-derived extracellular vesicles are involved in epidermal cell growth [PDF]

Stem Cell Research & Therapy, 2020
Millions suffer from skin diseases. Functional interfollicular epidermal stem cells are needed in skin therapy or drug screening in vitro. We obtained functional interfollicular epidermal stem cells with intact stemness and cell junctions by treating ...
Ling Leng, Jie Ma, Luye Lv, Wenjuan Wang, Dunqin Gao, Yunping Zhu, Zhihong Wu   +6 more
doaj   +2 more sources

CD4 expression controls epidermal stem cell balance [PDF]

Scientific Reports
The balance of stem cell populations is essential for the maintenance, renewal, and repair of the mammalian epidermis. Here, we report that CD4, which is a typical marker of helper T cells, monocytes, macrophages, and dendritic cells, is also expressed ...
Nadine Brandes, Heidi Hahn, Anja Uhmann
doaj   +2 more sources

Andrographis paniculata Extract Supports Skin Homeostasis by Enhancing Epidermal Stem Cell Function and Reinforcing Their Extracellular Niche [PDF]

Cells
Skin aging is characterized by compromised epidermal homeostasis and dermo-epidermal junction (DEJ) integrity, resulting in reduced stem cell potential and impaired tissue regeneration.
Roberta Lotti, Laetitia Cattuzzato, Xuefeng Huang, David Garandeau, Elisabetta Palazzo, Marika Quadri, Cécile Delluc, Eddy Magdeleine, Xiaojing Li, Mathilde Frechet, Alessandra Marconi   +10 more
doaj   +2 more sources

Transcriptional and epigenetic mechanisms governing epidermal stem cell regulation [PDF]

Frontiers in Cell and Developmental Biology
Epithelial stem cells in the interfollicular epidermis (IFE) and hair follicle (HF) play key roles in maintaining and regenerating the skin barrier by balancing self-renewal and differentiation.
Shaelin Lamb, Zuri Omari, Lindsey Seldin, Lindsey Seldin, Lindsey Seldin, Lindsey Seldin   +5 more
doaj   +2 more sources

EGFR-mediated epidermal stem cell motility drives skin regeneration through COL17A1 proteolysis. [PDF]

J Cell Biol, 2021
Nanba D, Toki F, Asakawa K, Matsumura H, Shiraishi K, Sayama K, Matsuzaki K, Toki H, Nishimura EK.   +8 more
europepmc   +2 more sources

AQP5 regulates the proliferation and differentiation of epidermal stem cells in skin aging [PDF]

Brazilian Journal of Medical and Biological Research, 2020
The epidermis, the outermost layer of the skin, is the first barrier that comes into contact with the external environment. It plays an important role in resisting the invasion of harmful substances and microbial infections. The skin changes with age and
Jing Zhou, Yabing Dong, Jianlan Liu, Jie Ren, Jinyan Wu, Ningwen Zhu   +5 more
doaj   +2 more sources

Gremlin 2 suppresses differentiation of stem/progenitor cells in the human skin

Regenerative Therapy, 2021
Introduction: The skin is comprised of various kinds of cells and has three layers, the epidermis, dermis and subcutaneous adipose tissue. Stem cells in each tissue duplicate themselves and differentiate to supply new cells that function in the tissue ...
Mika Kawagishi-Hotta, Seiji Hasegawa, Yu Inoue, Yuichi Hasebe, Masaru Arima, Yohei Iwata, Kazumitsu Sugiura, Hirohiko Akamatsu   +7 more
doaj   +1 more source

Dwarfing and the Underlying Morphological Changes of Poa alpigena Plants in Response to Overgrazing Conditions

Plants, 2022
Poa alpigena is a dominant grass species in alpine meadows, which is sensitive to environmental conditions. In this study, we analyzed the characteristics of the anatomical structure of the stems and leaves of Poa alpigena in overgrazed and enclosed ...
Hongxiao Shi, Xinhong Wu, Hai Wang, Sibagen Ha, Tingting Yang, Wenhui Liu   +5 more
doaj   +1 more source

Laminin 332-Dependent YAP Dysregulation Depletes Epidermal Stem Cells in Junctional Epidermolysis Bullosa

Cell Reports, 2019
Summary: Laminin 332-deficient junctional epidermolysis bullosa (JEB) is a severe genetic skin disease. JEB is marked by epidermal stem cell depletion, the origin of which is unknown.
Laura De Rosa, Alessia Secone Seconetti, Giorgio De Santis, Giovanni Pellacani, Tobias Hirsch, Tobias Rothoeft, Norbert Teig, Graziella Pellegrini, Johann W. Bauer, Michele De Luca   +9 more
doaj   +1 more source