Results 51 to 60 of about 5,134,709 (287)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

"Properties of Vibrissa follicle cells during follicle development and regeneration, and their interactions with embryonic stem cells." [PDF]

, 2001
Follicular dermal cells possess properties that regulate induction of follicle formation, hair growth, and follicle end bulb regeneration after amputation.
Harris, Susan Jane
core  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Differentiation of nonhuman primate pluripotent stem cells into functional keratinocytes

Stem Cell Research & Therapy, 2017
Background Epidermal grafting using cells derived from pluripotent stem cells will change the face of this side of regenerative cutaneous medicine.
Sophie Domingues, Yolande Masson, Aurore Marteyn, Jennifer Allouche, Anselme L. Perrier, Marc Peschanski, Cecile Martinat, Christine Baldeschi, Gilles Lemaître   +8 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Aldefluor protocol to sort keratinocytes stem cells from skin [PDF]

Acta Cirúrgica Brasileira, 2017
Purpose: To investigate the use Aldefluor® and N, N - Dimethylaminobenzaldehyde (DEAB) to design a protocol to sort keratinocyte stem cells from cultured keratinocytes from burned patients.
Samuel Marcos Ribeiro Noronha, Alfredo Gragnani, Thiago Antônio Calado Pereira, Silvana Aparecida Alves Correa, Jessica Bonucci, Lydia Masako Ferreira   +5 more
doaj   +1 more source

The Continuing Saga of Epidermal Stem Cells [PDF]

Journal of Investigative Dermatology, 2003
Ever sinceTill and McCulloch (1961) identified cells with the ability to recapitulate the hematopoietic tissue after radiation damage, isolating a pure population of stem cells from somatic tissues has been a primary goal. However, achieving success has been limited.
openaire   +2 more sources

Hair follicle germinative epidermal cells: a molecular study [PDF]

, 1999
At the base of the hair follicle epidermal matrix is a population of germinative epidermal (GE) cells that is in close communication with the dermal papilla.
Whitehouse, C.J., Whitehouse, Claire Jenna   +1 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

CD4 expression controls epidermal stem cell balance

Scientific Reports
The balance of stem cell populations is essential for the maintenance, renewal, and repair of the mammalian epidermis. Here, we report that CD4, which is a typical marker of helper T cells, monocytes, macrophages, and dendritic cells, is also expressed ...
Nadine Brandes, Heidi Hahn, Anja Uhmann
doaj   +1 more source