Results 51 to 60 of about 5,487,472 (290)
, 2014 Adipose-derived stem cells (ASCs) represent an important source of mesenchymal stem cells for clinical application. During in vitro culture, ASCs quickly lose the expression of transcription factors associated with pluripotency and self-renewal (Sox-2 ...
楊台鴻;鄭乃禎 +1 more
core +1 more source
Long-term expansion and differentiation of adult murine epidermal stem cells in 3D organoid cultures [PDF]
, 2019 Mammalian epidermal stem cells maintain homeostasis of the skin epidermis and contribute to its regeneration throughout adult life. While 2D mouse epidermal stem cell cultures have been established decades ago, a long-term, feeder cell- and serum-free ...
Wiener, Dominique J. +19 more
core +2 more sources
Differentiation of nonhuman primate pluripotent stem cells into functional keratinocytes
Stem Cell Research & Therapy, 2017 Background Epidermal grafting using cells derived from pluripotent stem cells will change the face of this side of regenerative cutaneous medicine.
Sophie Domingues +8 more
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Aldefluor protocol to sort keratinocytes stem cells from skin [PDF]
Acta Cirúrgica Brasileira, 2017 Purpose: To investigate the use Aldefluor® and N, N - Dimethylaminobenzaldehyde (DEAB) to design a protocol to sort keratinocyte stem cells from cultured keratinocytes from burned patients.
Samuel Marcos Ribeiro Noronha +5 more
doaj +1 more source
The Continuing Saga of Epidermal Stem Cells [PDF]
Journal of Investigative Dermatology, 2003 Ever sinceTill and McCulloch (1961) identified cells with the ability to recapitulate the hematopoietic tissue after radiation damage, isolating a pure population of stem cells from somatic tissues has been a primary goal. However, achieving success has been limited.
openaire +2 more sources
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
The in vitro plasticity of hair follicle dermal and mesenchymal stem cells [PDF]
, 2008 Stem cells from the hair follicle are an easily accessible population of cells that have a broad in vitro developmental capabilities and potential for autologous replacement of damaged adult tissue.
Emmerson, Robert
core
CD4 expression controls epidermal stem cell balance
Scientific ReportsThe balance of stem cell populations is essential for the maintenance, renewal, and repair of the mammalian epidermis. Here, we report that CD4, which is a typical marker of helper T cells, monocytes, macrophages, and dendritic cells, is also expressed ...
Nadine Brandes, Heidi Hahn, Anja Uhmann
doaj +1 more source
JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin
Nature Communications, 2018 Epidermal homeostasis is maintained by the activity of stem cells. Here, the authors show that deficiency of the transcription factor JunB leads to altered Notch signaling in stem cells, resulting in a cell fate switch and de novo formation of aberrant ...
Karmveer Singh +13 more
doaj +1 more source