eLife, 2017 The cutaneous wound-healing program is a product of a complex interplay among diverse cell types within the skin. One fundamental process that is mediated by these reciprocal interactions is the mobilization of local stem cell pools to promote tissue ...
Pedro Lee +11 more
doaj +1 more source
Transcriptional profiling of ectoderm specification to keratinocyte fate in human embryonic stem cells. [PDF]
PLoS ONE, 2015 In recent years, several studies have shed light into the processes that regulate epidermal specification and homeostasis. We previously showed that a broad-spectrum γ-secretase inhibitor DAPT promoted early keratinocyte specification in human embryonic ...
Ana Mafalda Baptista Tadeu +6 more
doaj +1 more source
Identification of a population of epidermal squamous cell carcinoma cells with enhanced potential for tumor formation. [PDF]
PLoS ONE, 2013 Epidermal squamous cell carcinoma is among the most common cancers in humans. These tumors are comprised of phenotypically diverse populations of cells that display varying potential for proliferation and differentiation. An important goal is identifying
Gautam Adhikary +11 more
doaj +1 more source
Shape-Induced Terminal Differentiation of Human Epidermal Stem Cells Requires p38 and Is Regulated by Histone Acetylation [PDF]
, 2011 PMCID: PMC3206954This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Connelly, JT +18 more
core +2 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Characterisation of apoptotic responses in human keratinocytes expressnig alpha-6 integrin and CD44 [PDF]
, 2010 PhDa6 integrin has previously been proposed as a human keratinocyte stem cell markers. CD44-positive cells in epithelial tumours have been identified as potential cancer stem cells (CSCs) and display increased survival following chemotherapy ...
Wray, Helen
core +4 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Zinc flux in skin: Identity and function of metallothionein 1–positive cells in skin homeostasis
JID InnovationsZinc is essential for skin homeostasis, yet the identity and function of zinc-rich epidermal cells remain poorly defined. MT1 (metallothionein-1), a zinc-responsive protein, is commonly used as an intracellular zinc marker, but whether MT1+ cells ...
Sofia Brito +6 more
doaj +1 more source
EGFR Controls Hair Shaft Differentiation in a p53-Independent Manner
iScience, 2019 Summary: Epidermal growth factor receptor (EGFR) signaling controls skin development and homeostasis in mice and humans, and its deficiency causes severe skin inflammation, which might affect epidermal stem cell behavior.
Nicole Amberg +8 more
doaj +1 more source
Stem cell decisions:A twist of fate or a niche market? [PDF]
, 2014 Establishing and maintaining cell fate in the right place at the right time is a key requirement for normal tissue maintenance. Stem cells are at the core of this process.
Näthke, Inke +3 more
core +1 more source