Results 21 to 30 of about 5,487,472 (290)

Notch promotes neural lineage entry by pluripotent embryonic stem cells [PDF]

, 2006
A central challenge in embryonic stem (ES) cell biology is to understand how to impose direction on primary lineage commitment. In basal culture conditions, the majority of ES cells convert asynchronously into neural cells.
Smith, Austin G, Austin G Smith, Heavey Barry, Alexandra Benchoua, Benchoua, Alexandra, Smith, Austin,, Benchoua Alexandra, Sally Lowell, Smith Austin G, Lowell, Sally; id_orcid, Smith, Austin, G., Lowell Sally, Lowell, Sally, Heavey, Barry, Barry Heavey   +14 more
core   +1 more source

Chronic inflammation of middle ear cholesteatoma promotes its recurrence via a paracrine mechanism

Cell Communication and Signaling, 2021
Background Cholesteatoma disease is an expanding lesion in the middle ear. Hearing loss and facial paralysis alongside with other intracranial complications are found.
Matthias Schürmann, Felix Oppel, Senyao Shao, Verena Volland-Thurn, Christian Kaltschmidt, Barbara Kaltschmidt, Lars-Uwe Scholtz, Holger Sudhoff   +7 more
doaj   +1 more source

Epidermal Cells Expressing Putative Cell Markers in Nonglabrous Skin Existing in Direct Proximity with the Distal End of the Arrector Pili Muscle

Stem Cells International, 2016
Inconsistent with the view that epidermal stem cells reside randomly spread along the basal layer of the epidermal rete ridges, we found that epidermal cells expressing stem cell markers in nonglabrous skin exist in direct connection with the distal end ...
N. Torkamani, N. W. Rufaut, L. Jones, R. Sinclair   +3 more
doaj   +1 more source

Single-keratinocyte transcriptomic analyses identify different clonal types and proliferative potential mediated by FOXM1 in human epidermal stem cells

Nature Communications, 2021
Epidermal cultures can treat skin diseases, such as Junctional Epidermolysis Bullosa, but the signature of stem cells is unclear. By single cell RNAseq analyses on human keratinocytes, the authors identify the molecular profile of holoclones and the role
Elena Enzo, Alessia Secone Seconetti, Mattia Forcato, Elena Tenedini, Maria Pia Polito, Irene Sala, Sonia Carulli, Roberta Contin, Clelia Peano, Enrico Tagliafico, Silvio Bicciato, Sergio Bondanza, Michele De Luca   +12 more
doaj   +1 more source

Epidermal Stem Cells

Journal of Investigative Dermatology, 1983
Stem cells are by definition present in all self-renewing tissues and are believed to play a central role in cell growth and differentiation. Existing evidence suggests that a subpopulation of epidermal basal keratinocytes represents stem cells; however, these cells have never been positively identified.
Lavker, Robert M., Sun, Tung-Tien
openaire   +2 more sources

Lineage Analysis of Epidermal Stem Cells [PDF]

Cold Spring Harbor Perspectives in Medicine, 2014
Lineage tracing involves labeling cells to track their subsequent behavior within the normal tissue environment. The advent of genetic lineage tracing and cell proliferation assays, together with high resolution three-dimensional (3D) imaging and quantitative methods to infer cell behavior from lineage-tracing data, has transformed our understanding of
Maria P, Alcolea, Philip H, Jones
openaire   +2 more sources

Regulation of boundary cap neural crest stem cell differentiation after transplantation [PDF]

, 2009
Success of cell replacement therapies for neurological disorders will depend largely on the optimization of strategies to enhance viability and control the developmental fate of stem cells after transplantation.
Hjerling-Leffler, J, Aldskogius, Hakan, Wegner, M, Hjerling-Leffler, Jens, Kozlova, Elena N, Medvinsky, Alexander, Berens, C, Aldskogius, H, Kozlova, EN, Berens, Christian, Kanaykina, Nadezda, Sandelin, Martin, Schreiner, S, Wegner, Michael, Kanaykina, N, Sandelin, M, Liakhovitskaia, A, Medvinsky, A, Liakhovitskaia, Anna, Schreiner, Silke, Kanaykina, Nadegda,, Kozlova, Elena,, Aldskogius, Håkan,, Sandelin, Martin,, Berens, Christian,   +24 more
core   +1 more source

Lack of correlation of stem cell markers in breast cancer stem cells [PDF]

, 2014
Background:Various markers are used to identify the unique sub-population of breast cancer cells with stem cell properties. Whether these markers are expressed in all breast cancers, identify the same population of cells, or equate to therapeutic ...
Y Liu, Appleyard, M. V., M V Appleyard, Liu, Y., P J Coates, Thompson, A. M., Boylan, M., Coates, P. J., Nenutil, R., M Boylan, A M Thompson, Murray, K., R Nenutil, K Murray   +13 more
core   +1 more source

Thy1 marks a distinct population of slow-cycling stem cells in the mouse epidermis

Nature Communications, 2022
The presence of distinct stem cells that maintain the interfollicular epidermis is highly debated. Here, we report a population of keratinocytes, marked by Thy1, in the basal layer of the interfollicular epidermis. We find that epidermal cells expressing
Elle Koren, Alona Feldman, Marianna Yusupova, Avihay Kadosh, Egor Sedov, Roi Ankawa, Yahav Yosefzon, Waseem Nasser, Stefanie Gerstberger, Liam B. Kimel, Noa Priselac, Samara Brown, Sam Sharma, Travis Gorenc, Ruby Shalom-Feuerstein, Hermann Steller, Tom Shemesh, Yaron Fuchs   +17 more
doaj   +1 more source

Heterogeneity and plasticity of epidermal stem cells [PDF]

Development, 2014
The epidermis is an integral part of our largest organ, the skin, and protects us against the hostile environment. It is a highly dynamic tissue that, during normal steady-state conditions, undergoes constant turnover. Multiple stem cell populations residing in autonomously maintained compartments facilitate this task.
Schepeler, Troels, Page, Mahalia E, Jensen, Kim Bak   +2 more
openaire   +3 more sources