Results 131 to 140 of about 29,755 (230)

Phytochemicals as Multitarget Therapeutics in Pancreatic Cancer: Mechanisms, Clinical Evidence, and Translational Challenges

Phytotherapy Research, Volume 40, Issue 10, Page 5973-5987, October 2026.
Pancreatic cancer, particularly pancreatic ductal adenocarcinoma, is aggressive and often diagnosed late, making treatment challenging. This review highlights the potential of phytochemicals, such as curcumin and quercetin, as multitarget agents that influence key carcinogenic pathways. These compounds exhibit anticancer effects by inhibiting processes
Md. Rezaul Islam, Abdur Rauf, F. M. Shourav, Hanan A. Ogaly, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Kamala Badalova, Marcello Iriti   +7 more
wiley   +1 more source

Epigallocatechin-3-gallate Modulates Hyperglycemia-Triggered Macrophage Autophagy Through miR-204-5p Suppression: Implication for Acute Cardiometabloic Injury. [PDF]

J Acute Med
Lin CM, Wang BW, Fang WJ, Pan CM, Shyu KG.   +4 more
europepmc   +1 more source

Ceratonia siliqua: Phytochemistry, Bioactivity, and Its Emerging Role as a Sustainable Food and Industrial Resource

Journal of Food Science, Volume 91, Issue 10, October 2026.
ABSTRACT Ceratonia siliqua L. (C. siliqua), commonly known as the carob tree, is an evergreen species of the Fabaceae family native to the Mediterranean basin and increasingly cultivated worldwide. Traditionally valued as animal feed and a natural sweetener, it has recently gained recognition as a multifunctional plant resource with nutritional ...
Anis Ben Hsouna, Ravendra Kumar, Manjul Gondwal, Shivangi Chamoli, Bhanu Pratap Singh Gautam, Simranpreet Kaur, Rakesh Kumar Verma, Piyush Kumar, Monika Michalak, Boutheina Ben Akacha, Wirginia Kukula‐Koch, Wojciech Koch, Faical Brini, Wissem Mnif, Rania Ben Saad, Stefania Garzoli, Miroslava Kačániová   +16 more
wiley   +1 more source

Epigallocatechin-3-Gallate (EGCG) as a Multifaceted Natural Anticancer Agent in Colorectal Cancer: Preclinical Evidence and Future Directions. [PDF]

Cancers (Basel)
Achilleos N, Harrison MT, Tsiani E.
europepmc   +1 more source

Novel Flavonoid Senotherapeutics Identified by Phenotypic Drug Discovery Reduce Senescence and Improve Multiple Markers of Healthspan

Aging Cell, Volume 25, Issue 10, October 2026.
Phenotypic screening and SAR‐guided drug design identified two flavonoid‐derived senolytics, SR29384 and SR31133, which selectively killed different types of senescent cells more efficiently and with greater selectivity than fisetin in culture. In aged and progeroid mice, these fisetin analogs reduced tissue senescence and improved physical function ...
Lei Justan Zhang, Rahagir Salekeen, Carolina Soto‐Palma, Qiuming Wu, Yuanjun He, Osama Elsallabi, Bilel Bdiri, Brian Hughes, Allancer Nunes, Wandi Xu, Borui Zhang, Abdalla Mohamed, Sara J. McGowan, Luise Angelini, Ryan O'Kelly, Theodore M. Kamenecka, Laura J. Niedernhofer, Paul D. Robbins   +17 more
wiley   +1 more source

Green Tea Polyphenol (-)-Epigallocatechin-3-gallate Protects Endothelial Barrier Function via Myosin Phosphatase and Rho-Kinase. [PDF]

Int J Mol Sci
Wakasugi R, Shiraki A, Mitsui R, Nishida S, Nishizaki A, Shibata S, Fukuda R, Suzuki K, Kaneko-Kawano T.   +8 more
europepmc   +1 more source

To Treat or Not to Treat: Navigating Early‐Stage CLL in the Era of Targeted Therapy

European Journal of Haematology, Volume 117, Issue 4, Page 750-766, October 2026.
ABSTRACT Chronic lymphocytic leukemia (CLL) is most frequently diagnosed at early, asymptomatic stages (Rai 0/Binet A), in which a watch‐and‐wait strategy remains the standard of care, based on historical trials demonstrating no overall survival benefit from early treatment.
Enrica Antonia Martino, Santino Caserta, Ernesto Vigna, Giovanna Cutrona, Antonella Bruzzese, Francesco Mendicino, Maria Eugenia Alvaro, Caterina Labanca, Eugenio Lucia, Virginia Olivito, Nicola Amodio, Franco Fais, Antonino Neri, Manlio Ferrarini, Valter Gattei, Fortunato Morabito, Massimo Gentile   +16 more
wiley   +1 more source

[Corrigendum] (‑)‑Epigallocatechin‑3‑gallate attenuates myocardial injury induced by ischemia/reperfusion in diabetic rats and in H9c2 cells under hyperglycemic conditions. [PDF]

Int J Mol Med
Wu Y, Xia ZY, Zhao B, Leng Y, Dou J, Meng QT, Lei SQ, Chen ZZ, Zhu J.   +8 more
europepmc   +1 more source

Plant‐Derived Senolytic Ingredient, Camellia sinensis Root Extract, Ameliorates Skin Aging‐Associated Phenotypes

Experimental Dermatology, Volume 35, Issue 10, October 2026.
Camellia sinensis root extract (SENOMUNE) preferentially reduced senescent dermal fibroblast viability and decreased SASP‐associated factor expression and secretion. Its effects were associated with features consistent with LMP/cathepsin/AIF‐associated caspase‐independent cell death.
Sunyoung Park, Siyoung Cho, Daejin Min, Hyunjung Choi, Kyeonghwan Hwang, In Sup Kil, Won‐Seok Park, Hyoung‐June Kim   +7 more
wiley   +1 more source

The Skin‐Lightening Efficacy and Mechanisms of Botanical Extracts: A Comprehensive Review

Journal of Cosmetic Dermatology, Volume 25, Issue 10, October 2026.
ABSTRACT Background Skin pigmentation is regulated by a complex network involving melanogenesis, melanosome transfer, oxidative stress, environmental stimuli, and epidermal turnover. Botanical extracts and phytochemicals have attracted increasing interest as potential skin‐lightening agents. This review evaluates their efficacy, mechanisms, and safety.
Siting Yang, Mingning Ding, Chenglong Ye, Jingning Shen, Lihua Zhang, Anquan Yang, Lihao Gu   +6 more
wiley   +1 more source