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Aging: Epigenetic modifications
2023Aging is one of the most complex and irreversible health conditions characterized by continuous decline in physical/mental activities that eventually poses an increased risk of several diseases and ultimately death. These conditions cannot be ignored by anyone but there are evidences that suggest that exercise, healthy diet and good routines may delay ...
Sarita, Mishra +4 more
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Maturitas, 2013
Over the past two decades, a growing interest on the research of the biological basis of human longevity has emerged, in order to clarify the intricacy of biological and environmental factors affecting (together with stochastic factors) the quality and the rate of human aging. These researches have outlined a complex scenario in which epigenetic marks,
D'Aquila P +3 more
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Over the past two decades, a growing interest on the research of the biological basis of human longevity has emerged, in order to clarify the intricacy of biological and environmental factors affecting (together with stochastic factors) the quality and the rate of human aging. These researches have outlined a complex scenario in which epigenetic marks,
D'Aquila P +3 more
openaire +2 more sources
Epigenetic clocks, aging, and cancer
Science, 2022Global methylation changes in aging cells affect cancer risk and tissue ...
Sarah E, Johnstone +3 more
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2020
Epigenetics is considered as a dynamic interface between the genome and the environment and encompasses different mechanisms that regulate chromatin dynamics and gene expression by DNA methylation, histone post-translational modifications, histone variants, non-coding RNAs, genome topology, among others.
Nancy Monroy-Jaramillo +1 more
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Epigenetics is considered as a dynamic interface between the genome and the environment and encompasses different mechanisms that regulate chromatin dynamics and gene expression by DNA methylation, histone post-translational modifications, histone variants, non-coding RNAs, genome topology, among others.
Nancy Monroy-Jaramillo +1 more
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Aging epigenetics: Causes and consequences
Molecular Aspects of Medicine, 2013Growth and development of higher organisms are regulated by the orchestrated change of epigenetic marks over time. In addition, there is also an epigenetic variation without any apparent role in development that is thought to be the result of the stochastic accumulation of epigenetic errors. The process depends on genetic and environmental factors and,
Covadonga, Huidobro +2 more
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2019
The term epigenetics refers to the heritable alterations not due to changes in DNA sequences, which modulate the individual phenotype by modulating the expression and the activity of genes (Armstrong, Epigenetics, Garland Science, New York, 2013; Pinel et al., BioSocieties 13:276–303, 2018).
Bellizzi D +4 more
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The term epigenetics refers to the heritable alterations not due to changes in DNA sequences, which modulate the individual phenotype by modulating the expression and the activity of genes (Armstrong, Epigenetics, Garland Science, New York, 2013; Pinel et al., BioSocieties 13:276–303, 2018).
Bellizzi D +4 more
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[Epigenetics and aging: How is epigenetics linked to aging?]
Medecine sciences : M/S, 2023Links between aging and epigenetics have been revealed by bio-mathematicians. Methylation of cytosine, which is a characteristic of the epigenome, varies with age on some ADN loci, increasing or decreasing. From an analysis of the methylome, algorithms giving an "epigenetic age" were obtained, strongly correlated with the age.
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Cancer-epigenetics comes of age
Nature Genetics, 1999The discovery of numerous hypermethylated promoters of tumour-suppressor genes, along with a better understanding of gene-silencing mechanisms, has moved DNA methylation from obscurity to recognition as an alternative mechanism of tumour-suppressor inactivation in cancer.
P A, Jones, P W, Laird
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Gene Expression, Epigenetics and Ageing
2018As the popular adage goes, all diseases run into old age and almost all physiological changes are associated with alterations in gene expression, irrespective of whether they are causal or consequential. Therefore, the quest for mechanisms that delay ageing and decrease age-associated diseases has propelled researchers to unravel regulatory factors ...
Babukrishna, Maniyadath +2 more
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